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Concepts and Experimental Protocols of Modelling and Informatics in Drug Design discusses each experimental protocol utilized in the field of bioinformatics, focusing especially on computer modeling for drug development. It helps the user in understanding the field of computer-aided molecular modeling (CAMM) by presenting solved exercises and examples. The book discusses topics such as fundamentals of molecular modeling, QSAR model generation, protein databases and how to use them to select and analyze protein structure, and pharmacophore modeling for drug targets. Additionally, it discusses data retrieval system, molecular surfaces, and freeware and online servers. The book is a valuable source for graduate students and researchers on bioinformatics, molecular modeling, biotechnology and several members of biomedical field who need to understand more about computer-aided molecular modeling. - Presents exercises with solutions to aid readers in validating their own protocol - Brings a thorough interpretation of results of each exercise to help readers compare them to their own study - Explains each parameter utilized in the algorithms to help readers understand and manipulate various features of molecules and target protein to design their study
This book addresses the changing role of networks and the evolving structure of an Infrastructure Superhighway. The requirements for leadership in telecommunications are reviewed from different viewpoints: Network operators, equipment manufacturers, software developers and user organizations. Emphasis is placed on multimedia and what multimedia solutions would mean to telephone utilities and endusers. Based on extensive research undertaken in Europe, US and Japan, Dimitris Chorafas identifies new domains of applications, presents the breakthroughs which have currently been achieved and outlines the systems solutions necessary to fruitfully exploit new technology.
A SCI-FI THRILLER THAT DELVES INTO THE MYSTERIES OF MAN’S GREATEST GIFT—THE MIND Do you wish to explore the mind’s unimaginable power as it seeks justice in a world tarnished by corrupt beings? Join brain cell biologist Dr Almast Newhart in his mind-boggling mission to rescue his loved ones from the evil clutches of Colonel Toros and his men. Guided by a team of well-wishers, his own mental prowess and the mysterious ‘golden beings’, Almast tries to pull off the impossible. Will he emerge successful or will he lose all that he has in the process? And what is ‘the transfer protocol’? Is it just another experiment or something else?? Read on to find out.
The effective design of scientific experiments is critical to success, yet graduate students receive very little formal training in how to do it. Based on a well-received course taught by the author, Experimental Design for Biologistsfills this gap. Experimental Design for Biologistsexplains how to establish the framework for an experimental project, how to set up a system, design experiments within that system, and how to determine and use the correct set of controls. Separate chapters are devoted to negative controls, positive controls, and other categories of controls that are perhaps less recognized, such as “assumption controls†and “experimentalist controls†. Furthermore, there are sections on establishing the experimental system, which include performing critical “system controls†. Should all experimental plans be hypothesis-driven? Is a question/answer approach more appropriate? What was the hypothesis behind the Human Genome Project? What color is the sky? How does one get to Carnegie Hall? The answers to these kinds of questions can be found in Experimental Design for Biologists. Written in an engaging manner, the book provides compelling lessons in framing an experimental question, establishing a validated system to answer the question, and deriving verifiable models from experimental data. Experimental Design for Biologistsis an essential source of theory and practical guidance in designing a research plan.
This two-volume set LNCS 5870/5871 constitutes the refereed proceedings of the four confederated international conferences on Cooperative Information Systems (CoopIS 2009), Distributed Objects and Applications (DOA 2009), Information Security (IS 2009), and Ontologies, Databases and Applications of Semantics (ODBASE 2009), held as OTM 2009 in Vilamoura, Portugal, in November 2009. The 83 revised full papers presented together with 4 keynote talks were carefully reviewed and selected from a total of 234 submissions. Corresponding to the four OTM 2009 main conferences CoopIS, DOA, IS, and ODBASE the papers are organized in topical sections on workflow; process models; ontology challenges; network complexity; modeling cooperation; information complexity; infrastructure; information; aspect-oriented approaches for distributed middleware; distributed algorithms and communication protocols; distributed infrastructures for cluster and Grid computing; object-based, component-based, resource-oriented, event-oriented, and service-oriented middleware; peer-to-peer and centralized infrastructures; performance analysis of distributed computing systems; reliability, fault tolerance, quality of service, and real time support; self* properties in distributed middleware; software engineering for distributed middleware systems; security and privacy in a connected world; ubiquitous and pervasive computing; information systems security; privacy and authentication; security policies and verification; managing ontologies; using ontologies; event processing; dealing with heterogeneity; building knowledge bases; and XML and XML schema.