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First published in 1992
The marine environment has been, and continues to be, a fruitful source of novel chemical compounds that are not found in terrestrial and freshwater organisms. Many of these substances show potential biomedical applications, which could lead to development of new pharmaceutical products. Research on the utilization of natural products from marine o
The Handbook of Clinical Toxicology of Animal Venoms is the first concise, one-volume book devoted to this important subject. The editors are internationally recognized authorities in the biology and clinical aspects of venomous and poisonous animals, and the chapter authors are world leaders in their respective fields of toxicology. All aspects of the topic are covered including information on the biology and taxonomy of poisonous animals, their venom or poison, diagnosis, and general treatment principles and specific treatment. The most up-to-date list of available antivenoms is provided. Coverage of venomous and poisonous animals is comprehensive, with thorough discussions on shellfish poisoning, ciguatera, fugu, coelenterates, stingrays, venous fish, blue-ringed octopus, sea-snakes, scorpions, spiders, insects, and gila lizards. Individual chapters focus on snakes and snakebite in Europe, Africa, Asia, Australia, North America, Central America, and South America. Nearly all clinical chapters have been written by clinicians with extensive experience treating the particular type of animal envenoming or poisoning under consideration. No other book brings together such a wealth of information in this field, and no other book provides it in a format useful to clinicians charged with the responsibility of treating envenomed or poisoned patients. The Handbook of Clinical Toxicology of Animal Venoms is an essential addition to all medical libraries, emergency departments, toxicology departments, poison information centers, and invaluable to all professionals working in these fields.
Ciguatera poisoning is a worldwide problem whose impact has serious health and economic ramifications. Ciguatera Seafood Toxins provides an introduction and technical reference for this syndrome, covering topics such as medical approaches to treatment, legal avenues for those who become poisoned, and an overview of the areas where ciguatera is common. Other chapters in the text discuss research issues, such as assay systems for ciguatera, neurological effects of the disease, and light and electron microscopy studies of tissue exposed to ciguatera-type toxins. The book provides comprehensive coverage of the laboratory techniques used in the purification and molecular characterization of the toxins implicated in the disease, as well as a discussion of the genetic variability of one of the causative organisms (Gambierdiscus toxicus) in culture. This is a "must have" book for anyone concerned with ciguatera poisoning and its legal, scientific, and medical consequences.
This new fifth edition of Information Resources in Toxicology offers a consolidated entry portal for the study, research, and practice of toxicology. Both volumes represents a unique, wide-ranging, curated, international, annotated bibliography, and directory of major resources in toxicology and allied fields such as environmental and occupational health, chemical safety, and risk assessment. The editors and authors are among the leaders of the profession sharing their cumulative wisdom in toxicology's subdisciplines. This edition keeps pace with the digital world in directing and linking readers to relevant websites and other online tools.Due to the increasing size of the hardcopy publication, the current edition has been divided into two volumes to make it easier to handle and consult. Volume 1: Background, Resources, and Tools, arranged in 5 parts, begins with chapters on the science of toxicology, its history, and informatics framework in Part 1. Part 2 continues with chapters organized by more specific subject such as cancer, clinical toxicology, genetic toxicology, etc. The categorization of chapters by resource format, for example, journals and newsletters, technical reports, organizations constitutes Part 3. Part 4 further considers toxicology's presence via the Internet, databases, and software tools. Among the miscellaneous topics in the concluding Part 5 are laws and regulations, professional education, grants and funding, and patents. Volume 2: The Global Arena offers contributed chapters focusing on the toxicology contributions of over 40 countries, followed by a glossary of toxicological terms and an appendix of popular quotations related to the field.The book, offered in both print and electronic formats, is carefully structured, indexed, and cross-referenced to enable users to easily find answers to their questions or serendipitously locate useful knowledge they were not originally aware they needed. Among the many timely topics receiving increased emphasis are disaster preparedness, nanotechnology, -omics, risk assessment, societal implications such as ethics and the precautionary principle, climate change, and children's environmental health. - Opens with an overview of the international toxicology scene, organizations and activities involved with both the science and regulatory framework, and a specific look at the European Union's efforts - Offers an extensive collection of chapters covering over 40 countries and their toxicological infrastructure which includes listings of major books and journals, organizations, professional societies, universities, poison control centers, legislation, and online databases - Provides the Second Edition of the International Union of Pure and Applied Chemistry's Glossary of Terms Used in Toxicology, a carefully constructed and peer reviewed collation of critical terms in the science - Concludes with a potpourri of quotes concerning toxicology and their use in the arts and popular culture - Paired with Volume One, which offers chapters on a host of toxicology sub-disciplines, this set offers the most comprehensive compendium of print, digital, and organizational resources in the toxicological sciences with over120 chapters contributions by experts and leaders in the field
Advances in Molecular Toxicology features the latest advances in all of the subspecialties of the broad area of molecular toxicology. Toxicology is the study of poisons, and this series details the study of the molecular basis by which a vast array of agents encountered in the human environment and produced by the human body itself manifest themselves as toxins. Not strictly limited to documenting these examples, the series is also concerned with the complex web of chemical and biological events that give rise to toxin-induced symptoms and disease. The new technologies that are being harnessed to analyze and understand these events will also be reviewed by leading workers in the field. Advances in Molecular Toxicology will report progress in all aspects of these rapidly evolving molecular aspects of toxicology with a view toward detailed elucidation of both progress on the molecular level and on advances in technological approaches employed. - Cutting-edge reviews by leading workers in the discipline - In-depth dissection of molecular aspects of interest to a broad range of scientists, physicians and any student in the allied disciplines - Leading edge applications of technological innovations in chemistry, biochemistry and molecular medicine
What chemicals are poisonous to the heart and why are they toxic? Find out by reading Principles of Cardiac Toxicology. Certain chemicals can produce toxicity by interacting with elements of the cardiovascular system. This book presents the anatomical, physiological, biochemical, and pathological basis for this interaction and describes the
The occurrence of marine and freshwater toxins is a rapidly evolving problem due to ever-changing circumstances. Expanding international commerce is forcing cargo ships into virgin territory, deforestation and pollution violate the natural ecological balance, and a changing climate holds unknown potential to alter current factors and trigger toxic blooms in new forms, at new rates, and in new places. Fortunately, with notable advances in analysis technology, the body of knowledge in the field is equally dynamic. In just six years since the first edition, toxins that warranted only line listings, including pfiestra, gambierol, and polycavernoside, are now worthy of entire chapters, requiring a new edition to encompass the expanding scope of the field. Emphasizes Human Response to New Toxins Gathering contributions from international experts, Seafood and Freshwater Toxins: Pharmacology, Physiology, and Detection, Second Edition provides an overview of the current state-of-knowledge from several perspectives. Incorporating toxicology, chemistry, ecology, and economics, the book covers the biological aspects of the bloom and the effects and actions of each toxin with emphasis on human response. This edition includes more information on detection and analysis, toxicological information on previously little known toxins, and food safety issues. Incorporating Pharmacological, Legal, and Economic Aspects, this book— Begins with general information on risk assessment and analytical techniques Cover several categories of toxins by function and biomechanism Considers potential pharmacological applications and the use of toxins as precursors to therapeutic drugs Highlights the legal and economic perspectives of toxic incidence in industrial activity and international regulation and monitoring programs Describes new toxins by their individual chemical structure, ecobiology, metabolism, detection methods, determination, pharmacology, and toxicology
Urbanization has reached unprecedented levels in the estuarine and coastal zone, particularly in the Asia Pacific region where mega-cities and mega-harbours are still growing. This book demonstrates the different solutions and pitfalls, successes and failures in a large number of ports and harbours in the Asia Pacific Region, and shows how science can provide ecologically sustainable solutions that apply wherever the growth of mega-harbours occurs.
Covering the most recent advances in our understanding of toxins from venomous animals and microbes as well as that of their targets, this book expertly addresses the many intriguing and unsolved questions concerning; proteomics studies of the "toxinome", intimate modes of toxin actions, molecular basis of specificity, pleiotropic properties of toxins and structural biology of toxins. Through twenty-seven chapters the authors discuss the role of structural genomics in toxinology, how toxins are subject to accelerated evolution, how toxins can be exploited as models for the design of new drugs, and what the future holds for the treatment of snake bites. In order to address these challenging aspects, the authors have posed crystal-clear questions. Based on the most precise knowledge the attendant reasoning shows how toxinology has become an important area of biochemistry and is directly associated with advances in cellular microbiology, molecular pharmacology, molecular physiology, cell biology, protein engineering and many other disciplines.