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Hardbound. Great progress has been made recently in basic and clinical research aspects of thrombosis and fibrinolysis. This progress has implications not only in haemorrhagic and thrombotic conditions, but also in such widely diverse clinical conditions as atherosclerosis, diabetes, obesity, tumor growth/metastasis, pregnancy etc. Procedures employed in this research include not only new biochemical approaches but also novel procedures in molecular biology which involve gene neutralisation, manipulation and transfection. In view of such new developments, the organisers thought it timely to have an International Symposium dealing with blood coagulation and fibrinolysis involving international experts and Japanese scientists. This book documents the proceedings and is beneficial to those wishing to update their information on this very important clinical area.
This book familiarizes the reader with some recent trends in the theory and practice of thrombolysis. It covers the field of fibrinolysis from the standpoint of basic scientists and clinicians and delivers the state-of-the-art information on the biochemistry and pharmacology of fibrinolysis, as well as related novel methodological and diagnostic tools in the field. An introductory chapter summarizes the basic molecular mechanisms in fibrinolysis (plasminogen, its endogenous activators and their inhibitors, plasmin and its inhibitors). Recent developments in our understanding of fibrin formation are described in the context of its impact on fibrinolysis. The discussion of neutrophil extracellular traps in the modulation of fibrin assembly and the consequences regarding plasminogen activation and plasmin action addresses a novel aspect of fibrinolysis.