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This volume of Progress in Clinical Neurosciences has updates on interesting topics ranging from skull base and vascular neurosurgery to innovation in endoscopic surgery including 3D and spinal surgery. In clinical neurology, there are updates on topics of common interest, i.e. neuroinfection, demyelination, stroke and headache. The role of embryogenesis is emphasized in the management of neurological disorders and the cranio-vertebral junction. The chapter on radiation biology and its complications focuses on the emerging field of tumour management. The chapters on vestibular schwanoma and multilevel cervical compressive myelopathy address the debate on the optimal surgical approach.
The topics covered in Volume 27 would be of direct relevance to neurospecialists in their day-to-day clinical practice. Advances in multiple sclerosis, ischemic stroke, epilepsy surgery and syringomyelia are elaborated for the reader. There is a comprehensive coverage of management of tumors in eloquent areas. Evidence-based management of spinal etastasis and the scientific evidence for decompressive craniotomy are presented. The controversies regarding the management of recurrent glioblastomas as well as the need to shunt a syrinx associated with Chiari malformation are strongly debated. Allied fields such as radiation therapy and neuropsychology are demystified and explained in a lucid manner.
This volume of Progress in Clinical Neurosciences follows the tradition of selecting topics likely to be of common interest to neurosurgeons, neurophysicians and other neuroscientists. Cutting-edge research and knowledge has been provided on neurogenetics, cognitive neuropsychology for aphasia and magnetoencephalography. The management of diffuse low-grade gliomas and aggressive and recurrent meningiomas has been updated. Reviews on lumbar arthroplasty and asymptomatic tethered cord highlight differing opinions. The chapters on Rating scales in neurosciences, Cerebral dominance and Neuromuscular disorders in the critical care unit present cross-disciplinary aspects.
This volume of Progress in Clinical Neurosciences is devoted in large part to various aspects of epilepsy--both medical and surgical. Spine and peripheral nerve surgery for various disorders is covered in detail. Both these sections have lively chapters on Controversies in surgical management. Current treatment options for neurological infections and Parkinson disease are other highlights of the book. Experimental stem cell therapy in neurological illnesses takes a look into the future, while Paediatric traumatic brain injury and Primary prevention of stroke offer solutions to everyday problems. These exhaustive reviews will benefit not only postgraduate students but will also update the knowledge of practising clinicians.
This volume of Progress in Clinical Neurosciences emphasizes on topics of common interest such as trauma and evidence-based neuro-oncology. Chapters on advances in MRI, newer radiation modalities such as CyberKnife and the search for new chemotherapeutics for brain tumours provide in-depth knowledge of the current trends. The chapters on an evidence-based approach to neurological examination, legal quantification of disability, myelopathies, CSF circulation disorders and painful ophthalmoplegias will be of interest to postgraduates as well as clinicians. Chapters on cervical disc disease and MCA aneurysm throw light on emerging debates.
This volume of Progress in Clinical Neurosciences comprises review articles on various aspects of movement disorders and cerebrovascular diseases in Neurology, and vascular surgery and neuro-oncology in Neurosurgery. Besides these, there are chapters on the Consumer Protection Act, normal pressure hydro-cephalus and miscellaneous topics. The authors of these chapters are well recognized for their work and the exhaustive review of the literature contained in the chapters will benefit not only postgraduate students but will also update the knowledge of practising clinicians.
This well-established international series examines major areas of basic and clinical research within neuroscience, as well as emerging and promising subfields. This volume on the neurosciences, neurology, and literature vividly shows how science and the humanities can come together --- and have come together in the past. Its sections provide a new, broad look at these interactions, which have received surprisingly little attention in the past. Experts in the field cover literature as a window to neurological and scientific zeitgeists, theories of brain and mind in literature, famous authors and their suspected neurological disorders, and how neurological disorders and treatments have been described in literature. In addition, a myriad of other topics are covered, including some on famous authors whose important connections to the neurosciences have been overlooked (e.g., Roget, of Thesaurus fame), famous neuroscientists who should also be associated with literature, and some overlooked scientific and medical men who helped others produce great literary works (e,g., Bram Stoker's Dracula). There has not been a volume with this coverage in the past, and the connections it provides should prove fascinating to individuals in science, medicine, history, literature, and various other disciplines. - This book looks at literature, medicine, and the brain sciences both historically and in the light of the newest scholarly discoveries and insights
New edition, completely rewritten, with new chapters on endovascular surgery and mitochrondrial and ion channel disorders.
A properly designed and executed clinical trial that addresses an import question and delivers a definitive result can change the practice of medicine worldwide. This book encompasses a bench-to-bedside approach and serves as an excellent guidance for translating preclinical studies to early phase I/II and phase III trials. In the first part, the book covers preclinical science with respect to animal models of various neurological diseases, FDA requirements for preclinical studies, translation of animal to patient studies and scaling up from animal to human studies. In the second part, the design of phase I/II trials and the use of biomarkers as surrogate endpoints are discussed. With regard to phase III trials, FDA and European requirements, specific design issues, relevant clinical endpoints as well as data management and quality are examined. Topics specific to multicenter trials, such as design, recruitment of special populations, monitoring, ethical and consent issues are also covered. Finally, genetics, gene therapy, imaging and surgical devices are reviewed.This publication is highly recommended to clinician researchers, such as neurologists, neurosurgeons, pediatric neurologists and neonatologists, who want to design and conduct clinical trials in the neuroscience, but also to nurses, research coordinators and clinical pharmacologists.
This second volume follows on from Part I by reviewing the variety of animal models of PD current available (from drosophila to rodents to non-human primate species) and their specific contributions to PD research. This is followed by comprehensive coverage of functional neuroimaging studies that explore different pathophysiological questions and evaluate treatment outcome in PD patients. Different areas of experimental therapeutics and outstanding challenges to PD treatment are presented in a concluding group of articles. - Complete overview of hot topics and approaches to current PD research, from molecules, to brain circuits, to clinical and therapeutic applications - Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future research - All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist