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Introduce technologies and practical know-how employed for cryogen-free systems of using 4 K cryocoolers to replace liquid helium; Address state of the arts of cryogen-free superconducting magnets, sub-kelvin refrigeration systems of He-3 sorption cooler, adiabatic demagnetization refrigerator (ADR) and dilution refrigerators (DR). Discuss applications of cryogen-free systems in modern instruments and equipment.