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Handbook of the Biology of Aging, Eighth Edition, provides readers with an update on the rapid progress in the research of aging. It is a comprehensive synthesis and review of the latest and most important advances and themes in modern biogerontology, and focuses on the trend of 'big data' approaches in the biological sciences, presenting new strategies to analyze, interpret, and understand the enormous amounts of information being generated through DNA sequencing, transcriptomic, proteomic, and the metabolomics methodologies applied to aging related problems. The book includes discussions on longevity pathways and interventions that modulate aging, innovative new tools that facilitate systems-level approaches to aging research, the mTOR pathway and its importance in age-related phenotypes, new strategies to pharmacologically modulate the mTOR pathway to delay aging, the importance of sirtuins and the hypoxic response in aging, and how various pathways interact within the context of aging as a complex genetic trait, amongst others. - Covers the key areas in biological gerontology research in one volume, with an 80% update from the previous edition - Edited by Matt Kaeberlein and George Martin, highly respected voices and researchers within the biology of aging discipline - Assists basic researchers in keeping abreast of research and clinical findings outside their subdiscipline - Presents information that will help medical, behavioral, and social gerontologists in understanding what basic scientists and clinicians are discovering - New chapters on genetics, evolutionary biology, bone aging, and epigenetic control - Provides a close examination of the diverse research being conducted today in the study of the biology of aging, detailing recent breakthroughs and potential new directions
The Arctic region has long held a fascination for explorers and scientists of many countries. Despite the numerous voyages of exploration, the na ture of the central Arctic was unknown only 90 years ago; it was believed to be a shallow sea dotted with islands. During Nansen's historic voyage on the polarship Fram, which commenced in 1893, the great depth of the central basin was discovered. In the Soviet Union, investigation of the Arctic Ocean became national policy after 1917. Today research at several scientific institutions there is devoted primarily to the study of the North Polar Ocean and seas. The systematic exploration of the Arctic by the United States com menced in 1951. Research has been conducted year-round from drifting ice islands, which are tabular fragments of glacier ice that break away from ice shelves. Most frequently, ice islands originate off the northern coast of Ellesmere Island. These research platforms are occupied as weather sta tions, as well as for oceanographic and geophysical studies. Several inter national projects, conducted by Canadian, European, and U. S. groups, have been underway during the last three decades. Although much new data have accumulated since the publication of the Marine Geology and Oceanography of the Arctic Seas volume in 1974 (Yvonne Herman, ed. ), in various fields of polar research-including present-day ice cover, hydrogra phy, fauna, flora, and geology-many questions remain to be answered.
The Word Biblical Commentary delivers the best in biblical scholarship, from the leading scholars of our day who share a commitment to Scripture as divine revelation. This series emphasizes a thorough analysis of textual, linguistic, structural, and theological evidence. The result is judicious and balanced insight into the meanings of the text in the framework of biblical theology. These widely acclaimed commentaries serve as exceptional resources for the professional theologian and instructor, the seminary or university student, the working minister, and everyone concerned with building theological understanding from a solid base of biblical scholarship. Overview of Commentary Organization Introduction—covers issues pertaining to the whole book, including context, date, authorship, composition, interpretive issues, purpose, and theology. Each section of the commentary includes: Pericope Bibliography—a helpful resource containing the most important works that pertain to each particular pericope. Translation—the author’s own translation of the biblical text, reflecting the end result of exegesis and attending to Hebrew and Greek idiomatic usage of words, phrases, and tenses, yet in reasonably good English. Notes—the author’s notes to the translation that address any textual variants, grammatical forms, syntactical constructions, basic meanings of words, and problems of translation. Form/Structure/Setting—a discussion of redaction, genre, sources, and tradition as they concern the origin of the pericope, its canonical form, and its relation to the biblical and extra-biblical contexts in order to illuminate the structure and character of the pericope. Rhetorical or compositional features important to understanding the passage are also introduced here. Comment—verse-by-verse interpretation of the text and dialogue with other interpreters, engaging with current opinion and scholarly research. Explanation—brings together all the results of the discussion in previous sections to expose the meaning and intention of the text at several levels: (1) within the context of the book itself; (2) its meaning in the OT or NT; (3) its place in the entire canon; (4) theological relevance to broader OT or NT issues. General Bibliography—occurring at the end of each volume, this extensive bibliography contains all sources used anywhere in the commentary.
Based on eight monographs presented and discussed at a working meeting of the International Institute for Educational Planning (IIEP) in 1977, this summational report is intended to be used by educational planners for a reduction of regional disparities through school network reorganization and improvements in educational service. Part I discusses the regional approach to the problem of educational disparities with reference to countries such as Thailand and Kenya, identifying both interregional and intraregional disparities. Part II establishes criteria for measuring disparities, beginning with such commonly used indicators as quantitative expansion of the education system and efficiency of educational service, and demonstrating three different types of evaluative analysis: evolution of disparities in time; evolution of disparities at different levels of the education system; and the relation between educational, economic, and social disparities. Part II also includes a proposed classification of educational indicators for analytical purposes. While part III focuses on disparities in educational access, school progress, and scholastic achievement, part IV reviews measures currently envisaged by governments for reducing regional disparities and discusses their implications for educational planning. (JBM)
WBC series delivers the best in biblical scholarship, from the leading scholars who share a commitment to Scripture as divine revelation. It emphasizes a thorough analysis of textual, linguistic, structural, and theological evidence. The result is judicious and balanced insight into the meanings of the text in the framework of biblical theology.