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Radioisotope; Radiation measurement; Statistics; Basic criteria; Radioactive decay; Properties of radiation and interaction with matter; Radiation detection and measurement; Nuclear analysis; Radiochemical separation techniques and chemistry and biological sciences.
These lectures were prepared by the authors for Seminars to be held on June 6, 1983, in St.Louis, Missouri, under the spon­ sorship of the Radiopharmaceutical Science Council of the So­ ciety of Nuclear Medicine . All manuscript? were refereed . Tracer kinetics and the modeling of physiological and bio­ chemical processes in vivo are the focus of a contemporary di­ rection in biochemical research. Recent advances in instrumen­ tation (especially positron emission tomography and digital autoradiography) and parallel developments in the production of short-lived radionuclides and rapid synthetic chemistry to pre­ pare tracers that probe metabolism, flow, receptor-ligand kinetics, etc., are responsible for new scientific frontiers. These developments, coupled with biomathematics and computer science, make it possible to quantitatively evaluate tracer kinetic models in animals and man. (The choice of animal models in radiotracer design and tracer kinetics is the subject of a book edited by R.M.Lambrecht and W.C.Eckleman in press at Sprin­ ger Verlag.) Tracer kinetics and physiological modeling is truly multi­ disciplinary, as evidenced by the intellectual diversity and international representation observable in the list of contri­ butors . The lectures outline and attempt to show the transition from the theoretical description to the practical application of modeling for understanding normal and pathological processes .
Uniquely integrates the theory and practice of key experimental techniques for bioscience undergraduates. Now includes drug discovery and clinical biochemistry.
The time-dependent decay of naturally occurring radioactive isotopes or in-growth of their radioactive or stable daughter products form the basis of radiometric dating of several natural processes. Developed in the beginning of the last century mainly to determine the absolute ages of rocks and minerals, radiometric chronology now plays a central role in a broad range of Earth and planetary sciences - from extra-solar-system processes to environmental geoscience. With the prerequisite of only college-level knowledge in physics, chemistry and mathematics, this concise book focuses on the essential principles of radiometric dating in order to enable students and teachers belonging to diverse fields of studies to select, understand and interpret radiometric dating results generated and published by professionals.
Over the past decade significant progress has been achieved in the development of waste characterization and control procedures and equipment as a direct response to ever-increasing requirements for quality and reliability of information on waste characteristics. Failure in control procedures at any step can have important, adverse consequences and may result in producing waste packages which are not compliant with the waste acceptance criteria for disposal, thereby adversely impacting the repository. The information and guidance included in this publication corresponds to recent achievements and reflects the optimum approaches, thereby reducing the potential for error and enhancing the quality of the end product. -- Publisher's description.
Principles of Physiological Measurement examines the basic principles underlying the techniques and instruments used in making measurements, including tracer methods and compartmental analysis. It describes measurements of oxygen, carbon dioxide, pH, ammonia, and miscellaneous gases such as hydrogen and nitrogen. The book also describes the general concepts of electrical transduction, amplification, and recording. Organized into 15 chapters, this volume begins with an overview of some fundamental concepts of measurement, including basic gas and solution concepts, electronics relevant to measurement methods, and error in designing experiments. Some chapters are dedicated to the measurement of oxygen in gases and in aqueous solutions, partial pressure measurement of carbon dioxide in liquids, measurement of intracellular pH, and measurement of ammonia in gases and in solutions. Other chapters discuss the blood gas measurement, problems of controlling the gaseous environment, and basic principles of flow, velocity, force, displacement, and pressure, along with common methods for their measurement. The final chapters deal with ions and solutions, radioisotope concepts and techniques, and tracer kinetics. This book will be of interest to natural scientists and students in physiology courses.
After World War II, the US Atomic Energy Commission (AEC) began mass-producing radioisotopes, sending out nearly 64,000 shipments of radioactive materials to scientists and physicians by 1955. Even as the atomic bomb became the focus of Cold War anxiety, radioisotopes represented the government’s efforts to harness the power of the atom for peace—advancing medicine, domestic energy, and foreign relations. In Life Atomic, Angela N. H. Creager tells the story of how these radioisotopes, which were simultaneously scientific tools and political icons, transformed biomedicine and ecology. Government-produced radioisotopes provided physicians with new tools for diagnosis and therapy, specifically cancer therapy, and enabled biologists to trace molecular transformations. Yet the government’s attempt to present radioisotopes as marvelous dividends of the atomic age was undercut in the 1950s by the fallout debates, as scientists and citizens recognized the hazards of low-level radiation. Creager reveals that growing consciousness of the danger of radioactivity did not reduce the demand for radioisotopes at hospitals and laboratories, but it did change their popular representation from a therapeutic agent to an environmental poison. She then demonstrates how, by the late twentieth century, public fear of radioactivity overshadowed any appreciation of the positive consequences of the AEC’s provision of radioisotopes for research and medicine.
Radioactive isotopes and enriched stable isotopes are used widely in medicine, agriculture, industry, and science, where their application allows us to perform many tasks more accurately, more simply, less expensively, and more quickly than would otherwise be possible. Indeed, in many casesâ€"for example, biological tracersâ€"there is no alternative. In a stellar example of "technology transfer" that began before the term was popular, the Department of Energy (DOE) and its predecessors has supported the development and application of isotopes and their transfer to the private sector. The DOE is now at an important crossroads: Isotope production has suffered as support for DOE's laboratories has declined. In response to a DOE request, this book is an intensive examination of isotope production and availability, including the education and training of those who will be needed to sustain the flow of radioactive and stable materials from their sources to the laboratories and medical care facilities in which they are used. Chapters include an examination of enriched stable isotopes; reactor and accelerator-produced radionuclides; partnerships among industries, national laboratories, and universities; and national isotope policy.