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Focus, Organization, and Content This book, like the first edition, deals with the mass transport processes that take place in living systems, with a focus on the normal behavior of eukaryotic cells and the - ganisms they constitute, in their normal physiological environment. As a consequence of this focus, the structure and content of the book differ from those of traditional transport texts. We do not start with the engineering principles of mass transport (which are well presented elsewhere) and then seek biological applications of these principles; rather, we begin with the biological processes themselves, and then - velop the models and analytical tools that are needed to describe them. This approach has several consequences. First of all, it drives the content of the text in a direction distinctively different from conventional transport texts. This is - cause the tools and models needed to describe complex biological processes are often different from those employed to describe more well-characterized inanimate systems. Many biological processes must still be described phenomenologically, using me- odologies like nonequilibrium thermodynamics. Simple electrical analogs employing a paucity of parameters can be more useful for characterization and prediction than complex theories based on the behavior of more well-defined systems on a laboratory bench. By allowing the biology to drive the choice of analysis tools and models, the latter are consistently presented in the context of real biological systems, and analysis and biology are interwoven throughout.
This text is designed for a first course in biological mass transport, and the material in it is presented at a level that is appropriate to advanced undergraduates or early graduate level students. Its orientation is somewhat more physical and mathematical than a biology or standard physiology text, reflecting its origins in a transport course that I teach to undergraduate (and occasional graduate) biomedical engineering students in the Whiting School of Engineering at Johns Hopkins. The audience for my cours- and presumably for this text - also includes chemical engineering undergraduates concentrating in biotechnology, and graduate students in biophysics. The organization of this book differs from most texts that at tempt to present an engineering approach to biological transport. What distinguishes biological transport from other mass transfer processes is the fact that biological transport is biological. Thus, we do not start with the engineering principles of mass transport (which are well presented elsewhere) and then seek biological ap plications of these principles; rather, we begin with the biological processes themselves, and then develop the tools that are needed to describe them. As a result, more physiology is presented in this text than is often found in books dealing with engineering applica tions in the life sciences.
Modeling of Microscale Transport in Biological Processes provides a compendium of recent advances in theoretical and computational modeling of biotransport phenomena at the microscale. The simulation strategies presented range from molecular to continuum models and consider both numerical and exact solution method approaches to coupled systems of equations. The biological processes covered in this book include digestion, molecular transport, microbial swimming, cilia mediated flow, microscale heat transfer, micro-vascular flow, vesicle dynamics, transport through bio-films and bio-membranes, and microscale growth dynamics. The book is written for an advanced academic research audience in the fields of engineering (encompassing biomedical, chemical, biological, mechanical, and electrical), biology and mathematics. Although written for, and by, expert researchers, each chapter provides a strong introductory section to ensure accessibility to readers at all levels.
Black & white print. Concepts of Biology is designed for the typical introductory biology course for nonmajors, covering standard scope and sequence requirements. The text includes interesting applications and conveys the major themes of biology, with content that is meaningful and easy to understand. The book is designed to demonstrate biology concepts and to promote scientific literacy.
For one-semester, advanced undergraduate/graduate courses in Biotransport Engineering. Presenting engineering fundamentals and biological applications in a unified way, this text provides students with the skills necessary to develop and critically analyze models of biological transport and reaction processes. It covers topics in fluid mechanics, mass transport, and biochemical interactions, with engineering concepts motivated by specific biological problems.
Over the past ten years several sophisticated in vitro test systems based on epithelial cell cultures have been introduced in the field of drug delivery. These models have been found to be very useful in characterizing the permeability of drugs across epithelial tissues, and in studying formulations or carrier systems for improved drug delivery and
What every neuroscientist should know about the mathematical modeling of excitable cells, presented at an introductory level.
This book provides a molecular view of membrane transport by means of numerous biochemical and biophysical techniques. The rapidly growing numbers of atomic structures of transporters in different conformations and the constant progress in bioinformatics have recently added deeper insights. The unifying mechanism of energized solute transport across membranes is assumed to consist of the conformational cycling of a carrier protein to provide access to substrate binding sites from either side of a cellular membrane. Due to the central role of active membrane transport there is considerable interest in deciphering the principles of one of the most fundamental processes in nature: the alternating access mechanism. This book brings together particularly significant structure-function studies on a variety of carrier systems from different transporter families: Glutamate symporters, LeuT-like fold transporters, MFS transporters and SMR (RND) exporters, as well as ABC-type importers. The selected examples impressively demonstrate how the combination of functional analysis, crystallography, investigation of dynamics and computational studies has made it possible to create a conclusive picture or more precisely, “a molecular movie”. Although we are still far from a complete molecular description of the alternating access mechanism, remarkable progress has been made from static snapshots towards membrane transport dynamics.
The first edition of this book was published in 2008 and it went on to become IWA Publishing’s bestseller. Clearly there was a need for it because over the twenty years prior to 2008, the knowledge and understanding of wastewater treatment had advanced extensively and moved away from empirically-based approaches to a fundamental first-principles approach based on chemistry, microbiology, physical and bioprocess engineering, mathematics and modelling. However the quantity, complexity and diversity of these new developments was overwhelming for young water professionals, particularly in developing countries without readily available access to advanced-level tertiary education courses in wastewater treatment. For a whole new generation of young scientists and engineers entering the wastewater treatment profession, this book assembled and integrated the postgraduate course material of a dozen or so professors from research groups around the world who have made significant contributions to the advances in wastewater treatment. This material had matured to the degree that it had been codified into mathematical models for simulation with computers. The first edition of the book offered, that upon completion of an in-depth study of its contents, the modern approach of modelling and simulation in wastewater treatment plant design and operation could be embraced with deeper insight, advanced knowledge and greater confidence, be it activated sludge, biological nitrogen and phosphorus removal, secondary settling tanks, or biofilm systems. However, the advances and developments in wastewater treatment have accelerated over the past 12 years since publication of the first edition. While all the chapters of the first edition have been updated to accommodate these advances and developments, some, such as granular sludge, membrane bioreactors, sulphur conversion-based bioprocesses and biofilm reactors which were new in 2008, have matured into new industry approaches and are also now included in this second edition. The target readership of this second edition remains the young water professionals, who will still be active in the field of protecting our precious water resources long after the aging professors who are leading some of these advances have retired. The authors, all still active in the field, are aware that cleaning dirty water has become more complex but that it is even more urgent now than 12 years ago, and offer this second edition to help the young water professionals engage with the scientific and bioprocess engineering principles of wastewater treatment science and technology with deeper insight, advanced knowledge and greater confidence built on stronger competence.