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Cancer control is the term applied to the development of integrated population-based approaches to reduce the incidence and mortality from cancer and to minimize its impact on affected individuals and on the community. The integrated nature of cancer control is reflected in this multi-disciplinary text, the first in this rapidly developing field.
This book is about Nutraceuticals in cancer therapy, specifically targeted and Adjuvant therapy. It shows several approaches for possibly reducing systemic toxicity. This book illustrates the role of several dietary agents, collectively called nutraceuticals or natural agents in the prevention and/or treatment of human malignancies known to be mediated through alterations in multiple molecular targets. This book contains sixteen chapters which begin with historical perspective on the value of natural agents in the prevention of human malignancies followed by a series of current topics on multiple nutraceuticals targeting multiple cancers. This collection would likely be useful for bringing newer generations with broader perspectives in launching cutting-edge innovative molecular research, which would certainly help in designing targeted clinical trials in order to realize the dream of customize strategies for the prevention and/or treatment of human malignancies without causing any systemic toxicity. Moreover, the knowledge gained would allow novel utilization of nutraceuticals as adjunct to both conventional chemotherapy and radiation therapy in order to improve the overall quality of life and survival of patients diagnosed with cancers.
Fundamentals of Cancer Detection, Treatment, and Prevention The professional guide to cancer diagnosis and therapy for researchers and clinicians In Fundamentals of Cancer Detection, Treatment, and Prevention, distinguished researcher Surya K. De delivers a concise and authoritative guide to cancer treatment, diagnosis, and prevention. The book offers a comprehensive overview of cancer in humans, from its causes, symptoms, and diagnosis to the variety of treatment options available today. Intuitively organized by cancer type, this guide provides concise information on risk factors, diagnosis, and treatment options for all commonly encountered tumors, including surgery, radiation therapy, chemotherapy, and immunotherapy. All US FDA-approved drugs—like small molecules, peptides, monoclonal antibodies, whole antibodies, gene therapy, antibody-drug conjugates, and cell therapies—are considered, and information about their generic and brand names, clinical uses, and mechanisms of action is presented. Readers will also find: A thorough overview of human cancers, including cancer risk factors and possible preventions Comprehensive explorations of bladder, blood, brain, and spinal cord cancers Practical discussions of breast, colorectal, cervical, kidney, and liver cancer In-depth examinations of lung, skin, ovarian, vaginal, vulvar, pancreatic, and prostate cancers, as well as mesothelioma Perfect for pharmaceutical chemists, oncologists, pharmacologists, and medicinal chemists, Fundamentals of Cancer Detection, Treatment, and Prevention is an indispensable guide for professional researchers, whether they are working in the clinic or the pharmaceutical industry.
Après trente-cinq ans voués à déchiffrer, à enseigner, à combattre le cancer, Lucien Israël nous livre des conclusions inédites sur la nature de la maladie et sa place dans l'évolution des espèces et des individus: il nous propose d'autres façons de la comprendre et de l'aborder. Eradiquer le cancer comme on l'a fait pour la plupart des maladies infectieuses, écrit le célèbre cancérologue, est illusoire. Car il s'agit d'une maladie liée à l'âge et à l'usure de nos défenses. Les cellules de notre organisme, qui accumulent les agressions au fil des années, n'ont que deux options: la mort ou la révolte, c'est-à-dire la transformation cancéreuse. Il n'est donc pas plus possible d'interdire le cancer que la vieillesse. En outre, explique Lucien Israël, les cancers ne sont pas le résultat de hasards génétiques, mais la réexpression d'un formidable programme de survie de nos cellules, hérité des bactéries qui ont triomphé de trois milliards d'années d'agressions, antibiotiques compris. Ce que montre ce livre, c'est qu'on doit pouvoir obtenir vis-à-vis des cancers le même effet de prévention, de freinage et de contrôle que celui obtenu dans les pays avancés vis-à-vis de l'âge. Mais pour y parvenir, il faudra modifier profondément les stratégies thérapeutiques et l'abord même de la maladie. C'est dans cette perspective que l'auteur expose ses désaccords avec les vues et les pratiques ambiantes, et formule des propositions nouvelles qui rouvrent le débat. Membre de l'Institut, professeur émérite de cancérologie, chef du service de cancérologie du C.H.U. Avicenne de 1976 à 1995, Lucien Israël est un cancérologue de renommée internationale. Outre de nombreuses publications scientifiques, il est l'auteur notamment de Cancer, les stratégies du futur (1989), de Vivre avec un cancer (1992) et de La Vie jusqu'au bout (1995).
The revelation that aspirin and aspirin-like compounds have notableantineo plastic properties has revolutionized cancer research. COX-2 Blockade in Cancer Prevention and Therapy chronicles the evidence and presents exciting new op portunities for the use of cyclooxygenase-2 (COX-2) blockade in the prevention and treatment of cancer. The text is divided broadly into five areas. First, an historical overview documents the scientific discovery ofCOX-2 and the pharma ceutical development of nonsteroidal anti-inflammatory drugs (NSAIDs) designed for selective COX-2 inhibition. The process by which essential poly unsaturated fatty acids (PUF As) stimulate prostaglandin biosynthesis and cancer development, and its interruption by COX-2 inhibition, is elucidated. This is followed by a section on the epidemiology of NSAIDs and cancers of the colon and breast, and other anatomic sites. These chapters reflect significant cancer protection owing to the regular use of common NSAIDs such as aspirin and ibuprofen. A section on animal models of carcinogenesis presents comprehensive evidence that general NSAIDs inhibit a variety of malignant neoplasms in vivo, and highlights recent findings which show that COX-2 blocking agents produce striking chemopreventive effects against colon cancer and breast cancer as well as other malignancies. Genetic models are presented confirming the critical role of COX-2 in carcinogenesis. Section IV then discusses the molecular biology of COX -2 vis-a-vis the role of COX -2 and, to a lesser extent, COX -1, in modulating a number of important processes in molecular carcinogenesis such as mutagen esis, cell division, angiogenesis, cell differentiation, and apoptosis.