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This book serves as the primary reference for precision medicine in the fields of pulmonary, critical care and sleep medicine by documenting principles written by experts in several aspects of precision medicine. It combines fundamental concepts of the field with state-of-the-art studies and how they translate into individual preventive, diagnostic and therapeutic plans. Precision medicine is focused on the integration of individual variability with disease prevention and treatment principles derived from population studies. This concept has risen to prominence in recent years in parallel with advances in genetics, molecular diagnostics and novel target-specific therapies. This fundamental shift in the approach to treatment has broad implications in how we prevent, diagnose and treat disease. Describing key concepts of precision medicine and relating these to pulmonary, critical care and sleep disorders is essential to educate relevant stakeholders and increase the impact of pulmonary precision medicine. The book is organized into seven sections: introduction; genetics; biomarkers; precise phenotyping; mobile health, wearables and telemedicine; precision therapeutics; and enabling widespread adoption of precision medicine. The chapters are organized with an introduction to the specific theme, followed by its basic concepts. They then delve into how these basic concepts relate to the larger theme of precision medicine, new precision medicine approaches to dealing with these problems, and key takeaway points. Liberally illustrated with images, figures, and tables, the text is thorough and intuitive for clinicians and researchers to learn the processes and applications of precision medicine. This is an ideal guide for clinicians to learn new precision medicine concepts in the fields of genetics, genomics, mobile health, and how they apply to their practice and their patients, as well as researchers seeking a basic understanding of precision medicine to assist in designing future research studies.
This issue of Sleep Medicine Clinics, edited by Dr. Susheel Patil in collaboration with Consulting Editor, Teogilo Lee-Chiong, is devoted to Precision Sleep Medicine. Topics covered in this issue include: The Promise of Precision Medicine in Sleep Medicine; Precision Medicine for Obstructive Sleep Apnea; Precision Medicine for Pediatric Obstructive Sleep Apnea; Precision Medicine for Hypersomnia; Precision Medicine for Insomnia; iCBTi: Tailoring CBTi for Chronic Insomnia Patients; Sleep Loss; Precision Medicine for REM Behavior Disorder; NREM Parasomnia: The Promise of Precision Medicine; Sleep Pharmacogenetics: The Promise of Precision Medicine; and Sleep and Memory: The Promise of Precision Medicine.
The Clinics Collections titles take a multidisciplinary approach to today's practice of medicine, selecting the most recent and relevant articles from the Clinics series and combining them into a single source of information on a focused topic. Articles are chosen from multiple Clinics to highlight the range of specialties covering major medical issues, delivering the information needed for successful interdisciplinary teamwork and effective patient care. Written from a variety of medical perspectives, these articles offer deeper insight into how each specialty cares for its patients and provide a unique entry into sharing best concepts for the entire medical team. Clinics Collections: Precision Medicine draws from Elsevier's Clinics Review Articles database to provide today's medical teams with practical clinical advice and insights on this timely medical model. It guides readers on how to apply current primary research findings to everyday practice, keep up with new and improved treatment methods, and improve patient outcomes. - Areas of focus include breast cancer, lung cancer, melanoma, arthritis, sleep medicine, and pediatric oncology. - Each article begins with keywords and key points for immediate access to the most critical information. - Articles are presented in an easy-to-digest and concisely worded format.
This book aims to foster machine and deep learning approaches to data-driven applications, in which data governs the behaviour of applications. Applications of Artificial intelligence (AI)-based systems play a significant role in today’s software industry. The sensors data from hardware-based systems making a mammoth database, increasing day by day. Recent advances in big data generation and management have created an avenue for decision-makers to utilize these huge volumes of data for different purposes and analyses. AI-based application developers have long utilized conventional machine learning techniques to design better user interfaces and vulnerability predictions. However, with the advancement of deep learning-based and neural-based networks and algorithms, researchers are able to explore and learn more about data and their exposed relationships or hidden features. This new trend of developing data-driven application systems seeks the adaptation of computational neural network algorithms and techniques in many application domains, including software systems, cyber security, human activity recognition, and behavioural modelling. As such, computational neural networks algorithms can be refined to address problems in data-driven applications. Original research and review works with model and build data-driven applications using computational algorithm are included as chapters in this book.
This is a book for clinician educators. It offers modern, evidence-based practices to use in teaching learners at a range of levels, with an emphasis on concrete strategies that teachers can implement in their own clinical practices as well as in small and large group settings. Medical education is rapidly changing with emerging evidence on best practices and a proliferation of new technologies. As strategies for effectively teaching medical learners evolve, it is important to understand the implications for Pulmonary, Critical Care, and Sleep Medicine (PCCM). This text is structured to allow easy access to the reader. Chapters are organized around level of learner (e.g., medical student to PCCM fellow to practicing physicians) as well as the location of teaching. Given the variety of clinical settings in which PCCM physicians teach, specific consideration of best practices, broad changes in curricular design and pedagogy are considered in different clinical contexts. Each chapter begins with a focus on why the topic is important for clinician educators. A review of the available evidence and relevant medical education theory about the topic follows, with examples from specific studies that provide insight into best practices regarding the concepts and topics discussed in the chapter. For chapters focusing on learners, different environments are considered and similarly, if the focus is on the learning environment, attention is paid to the approach to different learners. Each chapter ends with a summary of the primary points from the chapter and concrete examples of how clinician teachers can put the concepts discussed in the chapter into practice. This is an ideal guide for educators in pulmonary, critical care, and sleep medicine.
For nearly 30 years, Dr. Meir Kryger’s must-have guide to sleep medicine has been the gold standard in this fast-changing field. This essential, full-color reference includes more than 20 unique sections and over 170 chapters covering every aspect of sleep disorders, giving you the authoritative guidance you need to offer your patients the best possible care. Evidence-based content helps you make the most well-informed clinical decisions. An ideal resource for preparing for the sleep medicine fellowship examination. New content on sleep apnea, neurological disorders, legal aspects of sleep medicine, dental sleep medicine genetics, circadian disorders, geriatrics, women’s health, cardiovascular diseases, and occupational sleep medicine, keeps you fully up to date. Updates to scientific discoveries and clinical approaches ensure that you remain current with new knowledge that is advancing the diagnosis and management of sleep disorders.
Written specifically for non-sleep medicine specialists, this one-of-a-kind reference guides you through every aspect of this complex field with authoritative advice from Dr. Meir Kryger and other experts. Vibrantly illustrated in full color, it thoroughly covers the types of patients you're most likely to see in the outpatient setting and brings you up to date with the latest treatment methods, both surgical and non-surgical. - Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. - Complete coverage of the patients you're most likely to encounter, including special populations such as those with COPD, obesity hypoventilation, pregnancy, neuromuscular disorders, stroke, and more. - Specific information on topics of interest to a wide variety of physicians: heart failure and sleep disordered breathing; surgical treatments, including hypoglossal nerve stimulation; oral appliances and the treatment of sleep apnea; home sleep testing; and different types of PAP devices. - Ideal for pulmonologists, otolaryngologists, cardiologists, primary care physicians, dentists, and other healthcare providers who encounter patients with sleep and breathing disorders. - Full-color illustrations throughout, including a profusely illustrated chapter on physical diagnosis.
This issue of Sleep Medicine Clinics focuses on Novel Therapies for Sleep-Disorderd Breathing. Article topics include: The problems and pitfalls with current approaches to managing sleep disordered breathing; New approaches to diagnosing sleep disordered breathing; Monitoring progress and adherence with PAP therapy for OSA; The future of dental approaches for the treatment of OSA; Pharmacologic approaches for the treatment of OSA; Novel therapies for the treatment of central sleep apnea; Advances and new approaches to managing sleep disordered breathing related to chronic pulmonary disease; The role of big data in the management of sleep disordered breathing; Using genes and biomarkers to assess risk and identify optimal treatments for patients with sleep disordered breathing, and more!