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Over the last decade, Design of Experiments (DOE) has become established as a prime analytical and forecasting method with a vital role to play in product and process improvement. Now Practical Guide to Experimental Design lets you put this high-level statistical technique to work in your field, whether you are in the manufacturing or services sector. This accessible book equips you with all of the basic technical and managerial skills you need to develop, execute, and evaluate designed experiments effectively. You will develop a solid grounding in the statistical underpinnings of DOE, including distributions, analysis of variance, and more. You will also gain a firm grasp of full and fractional factorial techniques, the use of DOE in fault isolation and failure analysis, and the application of individual DOE methods within an integrated system. Each procedure is clearly illustrated one step at a time with the help of simplified notation and easy-to-understand spreadsheets. The book's real-world approach is reinforced throughout by case studies, examples, and exercises taken from a broad cross section of business applications. Practical Guide to Experimental Design is a valuable competitive asset for engineers, scientists, and decision-makers in many industries, as well as an important resource for researchers and advanced students. This hands-on guide offers complete, down-to-earth coverage of Design of Experiments (DOE) basics, providing you with the technical and managerial tools you need to put this powerful technique into action to help you achieve your quality improvement objectives. Using a clear, step-by-step approach, Practical Guide to Experimental Design shows you how to develop, perform, and analyze designed experiments. The book features: * Accessible coverage of statistical concepts, including data acquisition, reporting of results, sampling and other distributions, and more * A complete range of analytical procedures - analysis of variance, full and fractional factorial DOE, and the role of DOE in fault isolation and failure analysis * In-depth case studies, examples, and exercises covering a range of different uses of DOE * Broad applications across manufacturing, service, administrative, and other business sectors No matter what your field, Practical Guide to Experimental Design provides you with the "on-the-ground" assistance necessary to transform DOE theory into practice - the ideal guide for engineers, scientists, researchers, and advanced students.
While existing books related to DOE are focused either on process or mixture factors or analyze specific tools from DOE science, this text is structured both horizontally and vertically, covering the three most common objectives of any experimental research: * screening designs * mathematical modeling, and * optimization. Written in a simple and lively manner and backed by current chemical product studies from all around the world, the book elucidates basic concepts of statistical methods, experiment design and optimization techniques as applied to chemistry and chemical engineering. Throughout, the focus is on unifying the theory and methodology of optimization with well-known statistical and experimental methods. The author draws on his own experience in research and development, resulting in a work that will assist students, scientists and engineers in using the concepts covered here in seeking optimum conditions for a chemical system or process. With 441 tables, 250 diagrams, as well as 200 examples drawn from current chemical product studies, this is an invaluable and convenient source of information for all those involved in process optimization.
This book is a practical guide to help researchers draw valid causal inferences from small-scale clinical intervention studies. It should be of interest to teachers of, and students in, courses with an experimental clinical component, as well as clinical researchers. Inferential statistics used in the analysis of group data are frequently invalid for use with data from single-case experimental designs. Even non-parametric rank tests provide, at best, approximate solutions for only some single-case (and small-n ) designs. Randomization (Exact) tests, on the other hand, can provide valid statistical analyses for all designs that incorporate a random procedure for assigning treatments to subjects or observation periods, including single-case designs. These Randomization tests require large numbers of data rearrangements and have been seldom used, partly because desktop computers have only recently become powerful enough to complete the analyses in a reasonable time. Now that the necessary computational power is available, they continue to be under-used because they receive scant attention in standard statistical texts for behavioral researchers and because available programs for running the analyses are relatively inaccessible to researchers with limited statistical or computing interest. This book is first and foremost a practical guide, although it also presents the theoretical basis for Randomization tests. Its most important aim is to make these tests accessible to researchers for a wide range of designs. It does this by providing programs on CD-ROM that allow users to run analyses of their data within a standard package (Minitab, Excel, or SPSS) with which they are already familiar. No statistical or computing expertise is required to use these programs. This is the "new stats" for single-case and small-n intervention studies, and anyone interested in this research approach will benefit.
Featuring engaging examples from diverse disciplines, this book explains how to use modern approaches to quasi-experimentation to derive credible estimates of treatment effects under the demanding constraints of field settings. Foremost expert Charles S. Reichardt provides an in-depth examination of the design and statistical analysis of pretest-posttest, nonequivalent groups, regression discontinuity, and interrupted time-series designs. He details their relative strengths and weaknesses and offers practical advice about their use. Reichardt compares quasi-experiments to randomized experiments and discusses when and why the former might be a better choice. Modern moethods for elaborating a research design to remove bias from estimates of treatment effects are described, as are tactics for dealing with missing data and noncompliance with treatment assignment. Throughout, mathematical equations are translated into words to enhance accessibility.
Presenting essential material in a way that permits rapid application to practical problems, this guide provides the structure and understanding necessary for long-term growth. The author first explains how the components fit and work together to make a successful experimental design, then analyzes each component in detail, presenting the various a
The effective design of scientific experiments is critical to success, yet graduate students receive very little formal training in how to do it. Based on a well-received course taught by the author, Experimental Design for Biologistsfills this gap. Experimental Design for Biologistsexplains how to establish the framework for an experimental project, how to set up a system, design experiments within that system, and how to determine and use the correct set of controls. Separate chapters are devoted to negative controls, positive controls, and other categories of controls that are perhaps less recognized, such as “assumption controls†and “experimentalist controls†. Furthermore, there are sections on establishing the experimental system, which include performing critical “system controls†. Should all experimental plans be hypothesis-driven? Is a question/answer approach more appropriate? What was the hypothesis behind the Human Genome Project? What color is the sky? How does one get to Carnegie Hall? The answers to these kinds of questions can be found in Experimental Design for Biologists. Written in an engaging manner, the book provides compelling lessons in framing an experimental question, establishing a validated system to answer the question, and deriving verifiable models from experimental data. Experimental Design for Biologistsis an essential source of theory and practical guidance in designing a research plan.
Achieve Technological Advancements in Applied Science and Engineering Using Efficient Experiments That Consume the Least Amount of ResourcesWritten by longtime experimental design guru Thomas B. Barker and experimental development/Six Sigma expert Andrew Milivojevich, Quality by Experimental Design, Fourth Edition shows how to design and analyze ex
Specifically intended for lab-based biomedical researchers, this practical guide shows how to design experiments that are reproducible, with low bias, high precision, and widely applicable results. With specific examples from research using both cell cultures and model organisms, it explores key ideas in experimental design, assesses common designs, and shows how to plan a successful experiment. It demonstrates how to control biological and technical factors that can introduce bias or add noise, and covers rarely discussed topics such as graphical data exploration, choosing outcome variables, data quality control checks, and data pre-processing. It also shows how to use R for analysis, and is designed for those with no prior experience. An accompanying website (https://stanlazic.github.io/EDLB.html) includes all R code, data sets, and the labstats R package. This is an ideal guide for anyone conducting lab-based biological research, from students to principle investigators working in either academia or industry.
This book takes the reader through the entire research process: choosing a question, designing a study, collecting the data, using univariate, bivariate and multivariable analysis, and publishing the results. It does so by using plain language rather than complex derivations and mathematical formulae. It focuses on the nuts and bolts of performing research by asking and answering the most basic questions about doing research studies. Making good use of numerous tables, graphs and tips, this book helps to demystify the process. A generous number of up-to-date examples from the clinical literature give an illustrated and practical account of how to use multivariable analysis.
Getting numbers is easy; getting numbers you can trust is hard. This practical guide by experimentation leaders at Google, LinkedIn, and Microsoft will teach you how to accelerate innovation using trustworthy online controlled experiments, or A/B tests. Based on practical experiences at companies that each run more than 20,000 controlled experiments a year, the authors share examples, pitfalls, and advice for students and industry professionals getting started with experiments, plus deeper dives into advanced topics for practitioners who want to improve the way they make data-driven decisions. Learn how to • Use the scientific method to evaluate hypotheses using controlled experiments • Define key metrics and ideally an Overall Evaluation Criterion • Test for trustworthiness of the results and alert experimenters to violated assumptions • Build a scalable platform that lowers the marginal cost of experiments close to zero • Avoid pitfalls like carryover effects and Twyman's law • Understand how statistical issues play out in practice.