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Marlitt Erbe provides a detailed introduction into the young research field of Magnetic Particle Imaging (MPI) and field free line (FFL) imaging in particular. She derives a mathematical description of magnetic field generation for FFL imaging in MPI. To substantiate the simulation studies on magnetic FFL generation with a proof-of-concept, the author introduces the FFL field demonstrator, which provides the world’s first experimentally generated rotated and translated magnetic FFL field complying with the requirements for FFL reconstruction. Furthermore, she proposes a scanner design of considerably enhanced magnetic field quality and efficiency. The author discusses the influence of magnetic field quality optimization on the image quality achieved using efficient Radon-based reconstruction methods, which arise for a line detection scheme and based on this optimized design, presents a dynamic FFL scanner assembly.
Magnetic Particle Imaging (MPI) is a novel imaging modality. In MPI superparamagnetic iron oxide nanoparticles are used as tracer materials. The volume is the proceeding of the 2nd international workshop on magnetic particle imaging (IWMPI). The workshop aims at covering the status and recent developments of both, the instrumentation and the tracer material, as each of them is equally important in designing a well performing MPI. For instance, the current state of the art in magnetic coil design for MPI is discussed. With a new symmetrical arrangement of coils, a field-free line (FFL) can be produced that promises a significantly higher sensitivity compared with the standard arrangement for a FFP. Furthermore, the workshop aims at presenting results from phantom and pre-clinical studies.
This volume provides a comprehensive overview of recent developments in magnetic particle imaging (MPI), a novel imaging modality. Using various static and oscillating magnetic fields, and tracer materials made from iron oxide nanoparticles, MPI can perform background-free measurements of the particles’ local concentration. The method exploits the nonlinear remagnetization behavior of the particles and has the potential to surpass current methods for the detection of iron oxide in terms of sensitivity and spatiotemporal resolution. Starting from an introduction to the technology, the topics addressed include setting up an imaging device, assessment of image quality, development of new MPI tracer materials, and the first preclinical results. This is the first book to be published on magnetic particle imaging, and it will be an invaluable source of information for everyone with an interest in this exciting new modality.
Nanomedicine - the application of nanotechnology to human health - is a promising field of research at the interface of physical, chemical, biological, and medical science. Recent advances have made it possible to analyze biological systems at cellular and subcellular levels, offering numerous promising approaches to improve medical diagnosis and therapy. It is expected that nanomedicine will have a great impact especially on drug delivery and imaging. In this context, the development of targeted, highly specific nanoparticles is of pivotal importance. The results of these advances will offer personalized diagnostic tools and treatments in the future. Based on the 2nd Else Kröner-Fresenius-Symposium, this book presents a broad spectrum of topics ranging from nanoscale drug delivery/drug design to nanotoxicity and from diagnostics and imaging to therapeutic applications including antibody therapies. The contributions are authored by leading experts in the field and provide an excellent overview of the current knowledge in nanomedicine. Due to the interdisciplinary nature of the subject area this volume will be of special interest to physicians, biologists, chemists, engineers, and physicists as well as to students in the respective fields.
This second, completely updated and extended edition of the only reference work in this growing field of medical physics focuses on biomagnetic instrumentation as well as applications in cardiology and neurology. New chapters have been added on fetal magnetography and magnetic field therapy, as well as the safety aspects of magnetic fields. Written by well-known specialists from Germany, USA, Canada, Japan, the Netherlands and Scandinavia, the result is a manual for researchers in this field as well as for those who apply modern methods based on magnetism in medical practice. It equally provides a detailed overview for newcomers to the field as well as for experts familiar with only one part of the area.
Throughout most of the twentieth century, electric propulsion was considered the technology of the future. Now, the future has arrived. This important new book explains the fundamentals of electric propulsion for spacecraft and describes in detail the physics and characteristics of the two major electric thrusters in use today, ion and Hall thrusters. The authors provide an introduction to plasma physics in order to allow readers to understand the models and derivations used in determining electric thruster performance. They then go on to present detailed explanations of: Thruster principles Ion thruster plasma generators and accelerator grids Hollow cathodes Hall thrusters Ion and Hall thruster plumes Flight ion and Hall thrusters Based largely on research and development performed at the Jet Propulsion Laboratory (JPL) and complemented with scores of tables, figures, homework problems, and references, Fundamentals of Electric Propulsion: Ion and Hall Thrusters is an indispensable textbook for advanced undergraduate and graduate students who are preparing to enter the aerospace industry. It also serves as an equally valuable resource for professional engineers already at work in the field.
Considered a major field of photonics, plasmonics offers the potential to confine and guide light below the diffraction limit and promises a new generation of highly miniaturized photonic devices. This book combines a comprehensive introduction with an extensive overview of the current state of the art. Coverage includes plasmon waveguides, cavities for field-enhancement, nonlinear processes and the emerging field of active plasmonics studying interactions of surface plasmons with active media.
This unique book, written by one of the world's foremost specialists in the field, is devoted to the design of low and medium field electromagnets whose field level and quality (uniformity) are dominated by the pole shape and saturation characteristics of the iron yoke.The wide scope covers material ranging from the physical requirements for typical high performance accelerators, through the mathematical relationships which describe the shape of two-dimensional magnetic fields, to the mechanical fabrication, assembly, installation, and alignment of magnets in a typical accelerator lattice. In addition, stored energy concepts are used to develop magnetic force relationships and expressions for magnets with time varying fields.The material in the book is derived from lecture notes used in a course at the Lawrence Livermore National Laboratory and subsequently expanded for the U.S. Particle Accelerator School, making this text an invaluable reference for students planning to enter the field of high energy physics.Mathematical relationships tying together magnet design and measurement theory are derived from first principles, and chapters are included that describe mechanical design, fabrication, installation, and alignment. Some fabrication and assembly practices are reviewed to ensure personnel and equipment safety and operational reliability of electromagnets and their power supply systems. This additional coverage makes the book an important resource for those already in the particle accelerator business as well as those requiring the design and fabrication of low and medium field level magnets for charged particle beam transport in ion implantation and medical applications.
Students and researchers looking for a comprehensive textbook on magnetism, magnetic materials and related applications will find in this book an excellent explanation of the field. Chapters progress logically from the physics of magnetism, to magnetic phenomena in materials, to size and dimensionality effects, to applications. Beginning with a description of magnetic phenomena and measurements on a macroscopic scale, the book then presents discussions of intrinsic and phenomenological concepts of magnetism such as electronic magnetic moments and classical, quantum, and band theories of magnetic behavior. It then covers ordered magnetic materials (emphasizing their structure-sensitive properties) and magnetic phenomena, including magnetic anisotropy, magnetostriction, and magnetic domain structures and dynamics. What follows is a comprehensive description of imaging methods to resolve magnetic microstructures (domains) along with an introduction to micromagnetic modeling. The book then explores in detail size (small particles) and dimensionality (surface and interfaces) effects — the underpinnings of nanoscience and nanotechnology that are brought into sharp focus by magnetism. The hallmark of modern science is its interdisciplinarity, and the second half of the book offers interdisciplinary discussions of information technology, magnetoelectronics and the future of biomedicine via recent developments in magnetism. Modern materials with tailored properties require careful synthetic and characterization strategies. The book also includes relevant details of the chemical synthesis of small particles and the physical deposition of ultra thin films. In addition, the book presents details of state-of-the-art characterization methods and summaries of representative families of materials, including tables of properties. CGS equivalents (to SI) are included.