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Opening with a macabre mid-nineteenth century murder, The Mayne Inheritance unfolds like a gothic thriller. Was it the murder victim's money that founded patriarch Patrick Mayne's Queen Street business empire? And were the whispered accusations of murder and genetic madness true? For 150 years scandal and mystery have surrounded the Maynes, a wealthy family who donated the magnificent site on which the University of Queensland now stands.
Little Fish Are Sweet takes the reader behind the scenes of Matthew's Condon's epic six-year, three-book journey, as he fights intimidation and legal threats while relentlessly pursuing the truth. Investigating the web of cold murder cases and pedophile scandals of the past, Condon discovers that police corruption is only one part of a much bigger and more disturbing story. What is revealed in Little Fish are Sweet will make your blood boil.
The term arthrogryposis describes a range of congenital contractures that lead to childhood deformities. It encompasses a number of syndromes and sporadic deformities that are rare individually but collectively are not uncommon. Yet, the existing medical literature on arthrogryposis is sparse and often confusing. The aim of this book is to provide individuals affected with arthrogryposis, their families, and health care professionals with a helpful guide to better understand the condition and its therapy. With this goal in mind, the editors have taken great care to ensure that the presentation of complex clinical information is at once scientifically accurate, patient oriented, and accessible to readers without a medical background. The book is authored primarily by members of the medical staff of the Arthrogryposis Clinic at Children's Hospital and Medical Center in Seattle, Washington, one of the leading teams in the management of the condition, and will be an invaluable resource for both health care professionals and families of affected individuals.
In this luminous novel about romance and illusion—and what's left of love when they're stripped away—an American Anglophile is drawn into the lives of a disintegrating aristocratic family. After the sudden death of her husband, Annie Devereaux flees to England, site of the nostalgic fantasies her father spun for her before he deserted the family. A chance encounter in London leads Annie to cancel her return to New York and move in with Julian, the disaffected, moody son of Helena Denby, a famous British geneticist. As their relationship progresses, Annie meets Julian's sisters Isabel and Sasha, each of them fragile in her own way, and becomes infatuated with visions of their idyllic childhood in England's West Country. But the more she uncovers about Julian's past, the more he explodes into rage and violence. Finally tearing herself away, Annie winds up adrift in London, rescued from her loneliness only when she and Isabel form an unexpected bond. Slowly, with Isabel as her reluctant guide, Annie learns of the emotional devastation that Helena's warped arrogance, her monstrous will to dominate, inflicted on her children. The family who once embodied Annie's idealized conception of England is actually caught in a nightmare of betrayal and guilt that spirals inexorably into tragedy.
This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Generalized hypermobility has been known since ancient times, and a clinical description of Ehlers-Danlos syndrome (EDS) is said to have first been recorded by Hippocrates in 400 BC. Hypermobility syndromes occur frequently, but the wide spectrum of possible symptoms, coupled with a relative lack of awareness and recognition, are the reason that they are frequently not recognized, or remain undiagnosed. This book is an international, multidisciplinary guide to hypermobility syndromes, and EDS in particular. It aims to create better awareness of hypermobility syndromes among health professionals, including medical specialists, and to be a guide to the management of such syndromes for patients and practitioners. It is intended for use in daily clinical practice rather than as a reference book for research or the latest developments, and has been written to be understandable for any healthcare worker or educated patient without compromise to the scientific content. The book is organized as follows: chapters on classifications and genetics are followed by chapters on individual types, organ (system) manifestations and complications, and finally ethics and therapeutic strategies, with an appendix on surgery and the precautions which should attend it. A special effort has been made to take account of the perspective of the patient; two of the editors have EDS. The book will be of interest to patients with hypermobility syndromes and their families, as well as to all those healthcare practitioners who may encounter such syndromes in the course of their work.
“What the Communist Manifesto is to the capitalist world, Annihilation of Caste is to India.” —Anand Teltumbde, author of The Persistence of Caste The classic work of Indian Dalit politics, reframed with an extensive introduction by Arundathi Roy B.R. Ambedkar’s Annihilation of Caste is one of the most important, yet neglected, works of political writing from India. Written in 1936, it is an audacious denunciation of Hinduism and its caste system. Ambedkar – a figure like W.E.B. Du Bois – offers a scholarly critique of Hindu scriptures, scriptures that sanction a rigidly hierarchical and iniquitous social system. The world’s best-known Hindu, Mahatma Gandhi, responded publicly to the provocation. The hatchet was never buried. Arundhati Roy introduces this extensively annotated edition of Annihilation of Caste in “The Doctor and the Saint,” examining the persistence of caste in modern India, and how the conflict between Ambedkar and Gandhi continues to resonate. Roy takes us to the beginning of Gandhi’s political career in South Africa, where his views on race, caste and imperialism were shaped. She tracks Ambedkar’s emergence as a major political figure in the national movement, and shows how his scholarship and intelligence illuminated a political struggle beset by sectarianism and obscurantism. Roy breathes new life into Ambedkar’s anti-caste utopia, and says that without a Dalit revolution, India will continue to be hobbled by systemic inequality.