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This report presents a cost analysis of Polyisoprene production starting from raw sugar. The process examined is similar to Danisco/Goodyear process integrated with a typical solution polymerization process. In this process, raw sugar (sucrose) is diluted and sucrose is hydrolyzed into glucose and fructose (invert sugars). The invert sugars are then fed to an aerobic fermentation step to produce Isoprene, which is then polymerized to Polyisoprene. This report was developed based essentially on the following reference(s): Keywords: Dextrose, Genencor, DuPont, 2-Methyl-1,3-butadiene, Direct Fermentation, Synthetic Rubber, Goodyear, Goodrich, Snamprogetti, Ziegler Catalyst