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To the millions of Americans who suffer from chronic pain and arthritis, Vioxx seemed like a miracle. One of the most widely promoted and prescribed pain medications in the world -- used by more than twenty million people -- it was endorsed by the medical establishment and celebrities such as Olympic champion figure skater Dorothy Hamill. With annual sales of $2.5 billion, Vioxx became a pharmaceutical bonanza before being abruptly taken off the market in September 2004, after it was revealed that it led to an increased risk of heart-related disease and death. Drawing on internal documents, video footage, court testimony, and exclusive interviews, as well as three decades of experience inside the medical industry, Tom Nesi tells the dramatic story of what the drug's manufacturer, Merck, knew and when. It is a compelling narrative of business and medical science run amok, with a cast of characters ranging from those at the highest levels of the multibillion-dollar pharmaceutical industry to research scientists, marketers, and drug company sales reps. Here also are accounts from physicians, lawyers, financial analysts, and patients and their families whose lives have been forever altered by Vioxx. Set against a fascinating history of the origins of the modern pharmaceutical industry, POISON PILLS is a shocking tale that involves the breakdown of the United States medical system, the failures of the Food and Drug Administration, and enormous profits made by a large pharmaceutical corporation at the potential cost of thousands of lives.
Caught in a war that pits greed and ambition against conscience and love, Emma Conway faces the fight of her life-to save her family, her company, and everything she treasures. Emma is finally living the dream-a happy second marriage and a great career. She has built Percival & Baxter's painkiller, Acordinol, into a huge success. But her dream becomes a nightmare when a Wall Street raider threatens a hostile takeover. Worse, the raider is no ordinary cutthroat but her ex-husband Josh Katz, father of their teenage son. P&B's Poison Pill defense implodes when a mysteriously tainted batch of Acordinol starts killing people, including P&B's CEO. Emma is put in charge as P&B's stock plummets. Her ex's game traps her in a web of secrets locked within secrets. A shadowy Russian oligarch behind Josh is lusting after the holy grail of drugs, the first Viagra for women. And a clandestine romance between Emma's son and the oligarch's estranged daughter puts them in the crosshairs of their parents' mortal combat. New York Times bestselling author Glenn Kaplan looks inside the heart of today's business world to create page-turning suspense in a powerful tale of a woman who leans into success-and discovers deadly peril. At the Publisher's request, this title is being sold without Digital Rights Management Software (DRM) applied.
In this book, "All Medicines are Poison!," Melvin H. Kirschner, MPH, MD, sets out to remove the fog of confusion that clouds the landscape patients are required to navigate in their search for health care today. This book describes the risks and benefits associated with the use of medicines, and explores the validity of other treatment modalities referred to as "Complimentary and Alternative Medicine (CAM). He discusses the numerous failings and backroom dealings in the pharmaceutical and insurance industries, and highlights possible solutions to many of these current concerns. Dr. Kirschner has had an extensive career in the healthcare field. He has championed patient's rights throughout his career. As one of the key physicians instrumental in the enactment of the first biomedical ethical guidelines in the world, he has always strived for close doctor/patient relationships where the patient's concerns always come first.
Poisoning is a far more serious health problem in the U.S. than has generally been recognized. It is estimated that more than 4 million poisoning episodes occur annually, with approximately 300,000 cases leading to hospitalization. The field of poison prevention provides some of the most celebrated examples of successful public health interventions, yet surprisingly the current poison control "system" is little more than a loose network of poison control centers, poorly integrated into the larger spheres of public health. To increase their effectiveness, efforts to reduce poisoning need to be linked to a national agenda for public health promotion and injury prevention. Forging a Poison Prevention and Control System recommends a future poison control system with a strong public health infrastructure, a national system of regional poison control centers, federal funding to support core poison control activities, and a national poison information system to track major poisoning epidemics and possible acts of bioterrorism. This framework provides a complete "system" that could offer the best poison prevention and patient care services to meet the needs of the nation in the 21st century.
From echinacea to ayurvedics, this book explains how toxic these remedies are alone or in combination with other widely prescribed drug treatments. For example, one should avoid most herbal remedies when pregnant because of pesticides and preservatives required in growth and storage of the herbs; a widely used herbal antidepressant called kava does damage to the liver; most ayurvedic medicines contain unacceptable levels of lead and other heavy metals; St. John's Wort is not recommended if you are taking a medication for any chronic medical condition. Dr. Dasgupta explains in simple, engaging prose what drug interactions are and why they are dangerous. Most educated people see herbal remedies as "natural" and therefore "safe." Dr. Dasgupta tells us that one of his first pharmacology professors taught him that "medicine" is just another word for "poison" and should be treated with the same respect. He will present a balanced account of efficacy and safety of herbal medicines with discussion on potentially unsafe and toxic remedies. This book will be written in layman’s language for the consumer health market but will be based on solid medical research and published reports in the medical literature.
It's the drug of the century, a miracle weight loss compound worth billions, invented by Jon Vickers shortly before his death. So why is Jon's brother Benedict risking his inheritance, his brother's legacy, and even his own life to keep the drug from the market? And why is Olga Mueller, a jaded lawyer Benedict met by chance while traveling to Istanbul, willing to help? Can they take on a powerful venture capitalist and a ruthless top-tier law firm and win? Or even survive? In a world where money rules, does truth stand a chance?
A NEW YORK TIMES BESTSELLER * New York Times Notable Book * Best Book of the Year: New York Public Library, Kirkus Reviews, Science Friday With a new postscript by the author From an award-winning journalist, an explosive narrative investigation of the generic drug boom that reveals fraud and life-threatening dangers on a global scale—The Jungle for pharmaceuticals Many have hailed the widespread use of generic drugs as one of the most important public-health developments of the twenty-first century. Today, almost 90 percent of our pharmaceutical market is comprised of generics, the majority of which are manufactured overseas. We have been reassured by our doctors, our pharmacists and our regulators that generic drugs are identical to their brand-name counterparts, just less expensive. But is this really true? Katherine Eban’s Bottle of Lies exposes the deceit behind generic-drug manufacturing—and the attendant risks for global health. Drawing on exclusive accounts from whistleblowers and regulators, as well as thousands of pages of confidential FDA documents, Eban reveals an industry where fraud is rampant, companies routinely falsify data, and executives circumvent almost every principle of safe manufacturing to minimize cost and maximize profit, confident in their ability to fool inspectors. Meanwhile, patients unwittingly consume medicine with unpredictable and dangerous effects. The story of generic drugs is truly global. It connects middle America to China, India, sub-Saharan Africa and Brazil, and represents the ultimate litmus test of globalization: what are the risks of moving drug manufacturing offshore, and are they worth the savings? A decade-long investigation with international sweep, high-stakes brinkmanship and big money at its core, Bottle of Lies reveals how the world’s greatest public-health innovation has become one of its most astonishing swindles.
An analysis of the challenge that India's poison culture posed for colonial rule and toxicology's creation of a public role for science.
Mergers and Acquisitions Basics: All You Need to Know provides an introduction to the fundamental concepts of mergers and acquisitions. Key concepts discussed include M&As as change agents in the context of corporate restructuring; legal structures and strategies employed in corporate restructuring; takeover strategies and the impact on corporate governance; takeover defenses; and players who make mergers and acquisitions happen. The book also covers developing a business plan and the tools used to evaluate, display, and communicate information to key constituencies both inside and outside the corporation; the acquisition planning process; the negotiation, integration planning, and closing phases; financing transactions; and M&A post-merger integration.This book is written for buyers and sellers of businesses, financial analysts, chief executive officers, chief financial officers, operating managers, investment bankers, and portfolio managers. Others who may have an interest include bank lending officers, venture capitalists, government regulators, human resource managers, entrepreneurs, and board members. The book may also be used as a companion or supplemental text for undergraduate and graduate students taking courses on mergers and acquisitions, corporate restructuring, business strategy, management, governance, and entrepreneurship. - Describes a broad view of the mergers and acquisition process to illustrate agents' interactions - Simplifies without overgeneralizing - Bases conclusions on empirical evidence, not experience and opinion - Features a recent business case at the end of each chapter