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A key text for all those involved in pharmacovigilance. Detection of new adverse drug reactions is fundamental to the protection of patients from harm that may occur as a result of medication. This book explores the methods used to investigate new adverse drug reactions, discussing all elements from the scientific background and animal toxicology through to worldwide regulatory and ethical issues. Stephens' Detection of New Adverse Drug Reactions provides comprehensive and up-to-date coverage of material fundamentally important to all those active in the field, whether they work in the pharmaceutical industry, drug regulatory authorities or in academia. The fifth edition of this classic reference work includes new chapters on: vaccine safety surveillance managing drug safety issues with marketed products operational aspects of drug safety function safety of biotechnology products future of pharmacovigilance Reviews of previous editions: "This book surpasses all its educational aims. Not only is the subject matter covered comprehensively but the material is presented in a very user-friendly manner. The editors have succeeded in producing a highly-specific, definitive reference book which doubles as a most enjoyable read." —Commended by the 1999 BMA Medical Book Competition "For anyone entering the field of adverse reaction monitoring one could not wish for a better primer" —International Journal of Risk and Safety in Medicine
Authored by renowned leaders in the field, this comprehensive volume covers all aspects of drug-drug interactions, including preclinical, clinical, toxicological, and regulatory perspectives.Thoroughly updated, this second edition reflects the significant advances and includes extensive new material on:key interplay between transporters and enzymes
AIDS treatments continues to evolve. Now, so does the definitive reference on this complex and challenging subject! "AIDS Therapy, 3rd Edition" not only brings you comprehensive guidance on the latest treatments for HIV/AIDS and the full range of related disorders and syndromes, but also comes with access to updates online—so you can always tap into the most current therapy guidelines. Written by a "who's who" of leading global experts, the new edition of this classic reference is a must for any clinician who manages patients with HIV/AIDS. The most comprehensive coverage available on AIDS treatment equips you to meet any clinical challenge. Contributions from a large cast of noted international authorities put global "best practices" at your fingertips. Advice from some of the most respected experts in the field helps you manage your patients confidently. Available with a companion website allowing you to access the latest treatment guidelines year after year.
Covering everything from preoperative evaluation to neonatal emergencies to the PACU, A Practice of Anesthesia in Infants and Children, 6th Edition, features state-of-the-art advice on the safe, effective administration of general and regional anesthesia to young patients. It reviews underlying scientific information, addresses preoperative assessment and anesthesia management in detail, and provides guidelines for postoperative care, emergencies, and special procedures. Comprehensive in scope and thoroughly up to date, this 6th Edition delivers unsurpassed coverage of every key aspect of pediatric anesthesia. - Includes a laminated pocket reference guide inside with essential, practical information. - Features key references at the end of each chapter that provide a quick summary for review. - Presents must-know information on standards, techniques, and the latest advances in pediatric anesthesia from global experts. - Provides access to a video library of 70 pediatric anesthesia procedures – 35 are new! Videos include demonstrations on managing the difficult pediatric airway, cardiac assist devices in action, new positioning devices, management of burn injuries, and many demonstrations of ultra-sound guided regional anesthesia blocks and techniques. - Features extensive revisions of all chapters with many new contributors, and numerous new figures and tables throughout. - Introduces new drugs such as those used to premedicate children and facilitate emergence from anesthesia, plus an up-to-date discussion of the drug approval process and detailed information on opioid safety for children with obstructive sleep. - Includes new chapters on pharmacogenomic implications of drugs in children and the anesthetic implications when caring for children with cancer. - Offers up-to-date information on the management of emergence agitation, sleep-disordered breathing, neonatal and pediatric emergencies, and the obese child and bariatric surgery. - The Essentials chapters, with extensive input from pediatrician experts, provide the latest information concerning hematology, pulmonology, oncology, hepatology, nephrology, and neurology. - Contains significant updates on perioperative fluid management, pharmacology, intravenous anesthesia and target controlled infusions, cystic fibrosis, new interventional devices for children with congenital heart defects, cardiopulmonary resuscitation, simulation in pediatric anesthesia, and much more. - Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.