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This book extensively discusses the biology of telomere with the help of advanced information. Developments in telomere researches have provided an interrelation of telomere dysfunction with cellular aging and several age-related human diseases. Some new findings and studies have further widened our knowledge of telomere functions, where telomeres have been demonstrated to be essential for microbial pathogen virulence and telomere proteins have significant non-telomeric cellular functions. This book presents current opinions on selected areas of telomere research and their implication, in the hope of benefitting interested individuals in their future studies and enhancing their research progress.
This is the second edition of a reference work aimed at all those concerned with dealing with tuberculosis control in developing countries. The book follows in the tradition of Kurt Toman's original work in this field, with the text set out in a question and answer format, grouped under three headings: case detection; treatment, and monitoring. The threat of tuberculosis is still potent, with two million deaths globally. This new edition, containing contributions from a number of experts in this field, addresses the resurgence of tuberculosis, and the emergence of multidrug-resistant bacilli, and the growth of HIV-infected individuals with tuberculosis, as well as recent scientific developments.
The emergence of extensively drug-resistant strains of tuberculosis, especially in countries with a high prevalence of human immunodeficiency virus, is a serious threat to global public health and jeopardizes efforts to effectively control the disease. This publication offers updated recommendations for the diagnosis and management of drug-resistant tuberculosis in a variety of geographical, economic and social settings, and the recording of data that enables the monitoring and evaluation of programs.--Publisher's description.
This unique textbook provides a concise and practical approach to clinical dilemmas involving the liver, pancreas, and biliary tree. Six major sections encompass (1) Hepatic, (2) Biliary, (3) Pancreas, (4) Transplantation, (5) Trauma, and (6) Innovative Technology. Each topic is written by recognized experts from an "e;experiential"e; viewpoint combined with evidence-based medicine. The book contains over 170 chapters and over 350 contributors. It is relevant to Surgical Oncologists, Hepato-Pancreato-Biliary (HPB) Surgeons, Transplant Surgeons, Traumatologists, HPB Interventionalists, General Surgeons, and trainees and students. The title of each chapter is in a form of a clinical scenario and each chapter begins with a Case Scenario and ends with Salient Points. Special debates are included in each section. There are numerous compelling images, detailed illustrations, comprehensive tables, thorough algorithms, and other adjunctive tools that enhance learning. The authors emanate from different corners of the world. The book is a valuable resource for faculty, students, surgical trainees, fellows, and all health care providers in the HPB/Trauma/Transplant/Oncology fields.
energy production, environmental management, transportation, communication, computation, and education. As the twenty-first century unfolds, nanotechnology's impact on the health, wealth, and security of the world's people is expected to be at least as significant as the combined influences in this century of antibiotics, the integrated circuit, and human-made polymers. Dr. Neal Lane, Advisor to the President for Science and Technology and former National Science Foundation (NSF) director, stated at a Congressional hearing in April 1998, "If I were asked for an area of science and engineering that will most likely produce the breakthroughs of tomorrow, I would point to nanoscale science and engineering. " Recognizing this potential, the White House Office of Science and Technology Policy (OSTP) and the Office of Management and Budget (OMB) have issued a joint memorandum to Federal agency heads that identifies nanotechnology as a research priority area for Federal investment in fiscal year 2001. This report charts "Nanotechnology Research Directions," as developed by the Interagency W orking Group on Nano Science, Engineering, and Technology (IWGN) of the National Science and Technology Council (NSTC). The report incorporates the views of leading experts from government, academia, and the private sector. It reflects the consensus reached at an IWGN-sponsored workshop held on January 27-29, 1999, and detailed in contributions submitted thereafter by members of the V. S. science and engineering community. (See Appendix A for a list of contributors.
The field of design and health, formerly known as the domain of healthcare design professionals, has now reached a turning point with the proliferation of a plethora of non-invasive wearable technologies, to provide the objective and near-real-time measurement of the impact of many features of the built environment on aspects of health, wellbeing and performance. In turn, new materials and the Internet of Things are allowing the development of smart buildings, which can interact with occupants to optimize their health, wellbeing, performance and overall experience. Companies that have previously focused on positioning themselves as "green" are now turning to positioning themselves in the marketplace as both green and healthy. This Special Issue will include articles that address new cutting edge technologies and materials at the interface between design and health, and review some of the latest findings related to studies which use these technologies. This SI will also suggest exciting future directions for the field. It will include articles which focus on the objective data gathered to document the effects of the built environment on health. Importantly, it will focus on the use of innovative methods of measurement, such as state-of-the-art wearable and environmental sensors, quantifying some aspects of health, such as stress and relaxation responses, activity, posture, sleep quality, cognitive performance and wellbeing outcomes. It will also examine the impacts of different elements of the built environment on these health and wellbeing outcomes. The published articles will focus on the design interventions informed by these measurements, along with innovative integrated building materials that can shape the design of built environments for better health, productivity, and performance. It will also address the return on investment (ROI) of such design interventions. This Special Issue will provide both the foundational knowledge and fundamentals for characterizing human health and wellbeing in the built environment, as well as the emerging trends and design methods for innovations in this field.
Chronic pain costs the nation up to $635 billion each year in medical treatment and lost productivity. The 2010 Patient Protection and Affordable Care Act required the Department of Health and Human Services (HHS) to enlist the Institute of Medicine (IOM) in examining pain as a public health problem. In this report, the IOM offers a blueprint for action in transforming prevention, care, education, and research, with the goal of providing relief for people with pain in America. To reach the vast multitude of people with various types of pain, the nation must adopt a population-level prevention and management strategy. The IOM recommends that HHS develop a comprehensive plan with specific goals, actions, and timeframes. Better data are needed to help shape efforts, especially on the groups of people currently underdiagnosed and undertreated, and the IOM encourages federal and state agencies and private organizations to accelerate the collection of data on pain incidence, prevalence, and treatments. Because pain varies from patient to patient, healthcare providers should increasingly aim at tailoring pain care to each person's experience, and self-management of pain should be promoted. In addition, because there are major gaps in knowledge about pain across health care and society alike, the IOM recommends that federal agencies and other stakeholders redesign education programs to bridge these gaps. Pain is a major driver for visits to physicians, a major reason for taking medications, a major cause of disability, and a key factor in quality of life and productivity. Given the burden of pain in human lives, dollars, and social consequences, relieving pain should be a national priority.
Diverse driving forces, processes and actors are responsible for different trends in the development of megacities and large urban areas. Under the dynamics of global change, megacities are themselves changing: On the one hand they are prone to increasing socio-economic vulnerability due to pronounced poverty, socio-spatial and political fragmentation, sometimes with extreme forms of segregation, disparities and conflicts. On the other hand megacities offer positive potential for global transformation, e.g. minimisation of space consumption, highly effective use of resources, efficient disaster prevention and health care options – if good strategies were developed. At present in many megacities and urban areas of the developing world and the emerging economies the quality of life is eroding. Most of the megacities have grown to unprecedented size, and the pace of urbanisation has far exceeded the growth of the necessary infrastructure and services. As a result, an increasing number of urban dwellers are left without access to basic amenities like clean drinking water, fresh air and safe food. Additionally, social inequalities lead to subsequent and significant intra-urban health inequalities and unbalanced disease burdens that can trigger conflict and violence between subpopulations. The guiding idea of our book lies in a multi- and interdisciplinary approach to the complex topic of megacities and urban health that can only be adequately understood when different disciplines share their knowledge and methodological tools to work together. We hope that the book will allow readers to deepen their understanding of the complex dynamics of urban and megacity populations through the lens of public health, geographical and other research perspectives.