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The placebo effect continues to fascinate scientists, scholars, and clinicians, resulting in an impressive amount of research, mainly in the field of pain. While recent experimental and clinical studies have unraveled salient aspects of the neurobiological substrates and clinical relevance of pain and placebo analgesia, an authoritative source remained lacking until now. By presenting and integrating a broad range of research, Placebo and Pain enhances readers’ knowledge about placebo and nocebo effects, reexamines the methodology of clinical trials, and improves the therapeutic approaches for patients suffering from pain. Review for Placebo and Pain:“This ambitious book is the first comprehensive and unified presentation of the placebo and nocebo phenomena in the area of pain. Written by the international leading experts in the field, the book provides an accurate up-to-date [work] on placebo and pain dealing with current perspectives and future challenging issues. --Ted Kaptchuk, Associate Professor of Medicine, Harvard Medical School Contains historical aspects of the placebo effect Discusses biological and psychological mechanisms of placebo analgesic responses Reviews implications of the placebo effect for clinical research and pain management Includes methodological and ethical aspects of the placebo effect
A complete reference source on central pain.
Due to the recent explosion of placebo research at many levels the Editors believe that a volume on Placebo would be a good addition to the Handbook of Experimental Pharmacology series. In particular, this volume will be built up on a meeting on Placebo which will be held in Tuebingen (Germany) in January 2013, and where the most prominent researchers in this field will present and exchange their ideas. The authors who will be invited to write chapters for this volume will be the very same speakers at this meeting, thus guaranteeing high standard and excellence in the topic that will be treated. The approach of the book is mainly pharmacological, including basic research and clinical trials, and the contents range from different medical conditions and systems, such as pain and the immune system, to different experimental approaches, like in vivo receptor binding and pharmacological/behavioral conditioning. Overall, the volume will give an idea of modern placebo research, of timely concepts in both experimental and clinical pharmacology, as well as of modern methods and tools in neuroscience.
Psychodynamic psychotherapy and psychoanalysis have had to defend themselves from a barrage of criticisms throughout their history. In this book David Jopling argues that the changes achieved through therapy are really just functions of placebos that rally the mind's native healing powers. It is a bold new work that delivers yet another blow to Freud and his followers.
This fourth volume contains further ground-breaking and highly relevant work. Taking on the placebo and nocebo phenomenon, pain management and muscles and pain the volume yet again promotes the forward thinking and cutting edge work of the Physiotherapy Pain Association. In Part 1 a number of internationally renowned clinicians and researchers have come together to produce the first published attempt to broadly address and critically appraise the placebo and nocebo phenomenon from a clinical perspective for physiotherapists. The information and the way the material is presented should fascinate as well as challenge readers to think and work differently. Understanding the placebo fully requires a radical shift in thinking about human recovery mechanisms and the way in which treatments can be triggered to work at their most efficient. Part 2 takes on three more pain management topics – the integration of pain management approaches and techniques for individual therapists working with individual patients or in ‘out-patient’ settings; information giving for patients and addressing the taxing problem of improving fitness in patients with chronic pain related incapacity. The last part is devoted to some major issues surrounding the relationship of muscles to pain. Many current beliefs about the role of muscles come under scrutiny and some are constructively challenged by new proposals. Perhaps the most exciting aspect of the work presented here is that physiotherapy, if it fully integrates the information provided into clinical practice, should be increasingly recognised as the central and essential component of modern management of musculoskeletal pain states. The Topical Issues in Pain series derives from the work, study days and seminars of the Physiotherapy Pain Association and is written by clinicians for clinicians. Each volume reviews the literature and presents best practice in a lively and understandable text. All clinicians will benefit from the straightforward advice.
Drug overdose, driven largely by overdose related to the use of opioids, is now the leading cause of unintentional injury death in the United States. The ongoing opioid crisis lies at the intersection of two public health challenges: reducing the burden of suffering from pain and containing the rising toll of the harms that can arise from the use of opioid medications. Chronic pain and opioid use disorder both represent complex human conditions affecting millions of Americans and causing untold disability and loss of function. In the context of the growing opioid problem, the U.S. Food and Drug Administration (FDA) launched an Opioids Action Plan in early 2016. As part of this plan, the FDA asked the National Academies of Sciences, Engineering, and Medicine to convene a committee to update the state of the science on pain research, care, and education and to identify actions the FDA and others can take to respond to the opioid epidemic, with a particular focus on informing FDA's development of a formal method for incorporating individual and societal considerations into its risk-benefit framework for opioid approval and monitoring.
In this chapter we discuss the various aspects of the clinical applications of placebo effects. In clinical studies, a placebo intervention is often nearly as potent as the effects of the verum that is applied, and placebo effects can have enduring positive consequences. Most research has focused on healthy humans and it is not clear whether the results reported in these people can be transferred to clinical populations. Initial studies on this topic have suggested that patients may profit more from conditioning, which involves a true reduction of the pain experience, than from expectation alone. This current knowledge about the placebo effect, especially about the analgesic placebo effect, suggests that it is time to use it in clinical practice. The concept of the additional placebo effect as part of an active pain treatment enables an ethical application of placebo mechanisms that can enhance the efficacy of pharmacologic—and potentially also psychologic—interventions.
A thorough collection of classic and contemporary resources about the placebo effect. The placebo effect is a fascinating but elusive phenomena. Although no standard definition of the placebo effect exists, it is generally understood as consisting of responses of individuals to the psychosocial context of medical treatments or clinical encounters, as distinct from specific physiological effects of medical interventions. The Placebo is the first book to compile a selection of classic and contemporary published articles on the topic. Systematic investigation of the placebo effect emerged in the 1950s in response to the development of randomized controlled clinical trials that used “inert” placebo interventions as a pivotal element of scientific evaluation of novel drugs. In recent years, scientific and scholarly investigation of the placebo effect has increased dramatically, reflecting a growing interest in the connection between mind and body with respect to health, the development of brain imaging techniques, dissatisfaction with the reductionist and technological orientation of biomedicine, and growing attention to the use of complementary and alternative medical treatments. The Placebo is organized into three sections: the nature and significance of the placebo effect, experimental studies of the placebo effect, and ethical issues of placebos in research and in clinical practice. This comprehensive sourcebook will be invaluable to investigators and scholars alike.
This concise but comprehensive guide covers common procedures in pain management necessary for daily practice, and includes topics on international pain medicine curricula, for example, the American Board of Anesthesiology, World Institute of Pain/Fellow of Interventional Pain Practice, and American Board of Pain Medicine. Treatments for pain are discussed, including nerve blocks (head, neck, back, pelvis and lower extremity). Chapters have a consistent format including high yield points for exams, and questions in the form of case studies. Pain: A Review Guide is aimed at trainees in pain medicine all over the world. This book will also be beneficial to all practitioners who practice pain.