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Proceedings of the Workshop Organized by the Pipeline Research Committee, Pipeline Division of the American Society of Civil Engineers, Leesburg, VA, March 28-29, 1996. The proceedings of this workshop identify and prioritize pipeline-related research needs to maintain the present pipeline infrastructure in an acceptable working condition and discuss ways to improve the condition of the thousands of miles of deteriorating water, sewer, oil, natural gas, and products pipelines on which the people of the United States and Canada depend.
The United States Department of Energy (DOE) has approximately 400 million liters (100 million gallons) of liquid high-level waste (HLW) stored in underground tanks and approximately 4,000 cubic meters of solid HLW stored in bins. The current DOE estimate of the cost of converting these liquid and solid wastes into stable forms for shipment to a geological repository exceeds $50 billion to be spent over several decades (DOE, 2000). The Committee on Long-Term Research Needs for Radioactive High-Level Waste at Department of Energy Sites was appointed by the National Research Council (NRC) to advise the Environmental Management Science Program (EMSP) on a long-term research agenda addressing the above problems related to HLW stored in tanks and bins at DOE sites.
What criteria are used to assess the scholarly merit of a thesis? What is the level of conceptualization that is expected in doctoral theses? How can you prepare to defend your thesis? What is the most effective route to achieving your doctorate? The starting point to achieving your doctorate is to appreciate how your thesis will be examined. The criteria that examiners use, the questions they ask in vivas and their reports provide templates against which theses are judged. So, why not start from this endpoint as you plan, undertake, write and defend your research? This book focuses specifically on how you, as a doctoral candidate, can raise your level of thinking about your chosen topic. Doing so will improve the quality of your research and ultimately contribute to knowledge. It also explores the nature of conceptualization which is sought by examiners in theses. As a candidate, the book provides those essential characteristics of doctorateness that examiners expect to find in your thesis. The book will also appeal to supervisors, examiners and those who conduct workshops for doctoral candidates and supervisors. This practical book includes extracts from theses, examiner reports and cameo accounts from doctoral examiners, supervisors and candidates. It also contains numerous visual models that explain relationships and processes for you to apply and use in your doctoral journey. Based upon contemporary practice, Stepping Stones to Achieving your Doctorate is an essential tool for doctoral candidates, supervisors and examiners.
Improving and Accelerating Therapeutic Development for Nervous System Disorders is the summary of a workshop convened by the IOM Forum on Neuroscience and Nervous System Disorders to examine opportunities to accelerate early phases of drug development for nervous system drug discovery. Workshop participants discussed challenges in neuroscience research for enabling faster entry of potential treatments into first-in-human trials, explored how new and emerging tools and technologies may improve the efficiency of research, and considered mechanisms to facilitate a more effective and efficient development pipeline. There are several challenges to the current drug development pipeline for nervous system disorders. The fundamental etiology and pathophysiology of many nervous system disorders are unknown and the brain is inaccessible to study, making it difficult to develop accurate models. Patient heterogeneity is high, disease pathology can occur years to decades before becoming clinically apparent, and diagnostic and treatment biomarkers are lacking. In addition, the lack of validated targets, limitations related to the predictive validity of animal models - the extent to which the model predicts clinical efficacy - and regulatory barriers can also impede translation and drug development for nervous system disorders. Improving and Accelerating Therapeutic Development for Nervous System Disorders identifies avenues for moving directly from cellular models to human trials, minimizing the need for animal models to test efficacy, and discusses the potential benefits and risks of such an approach. This report is a timely discussion of opportunities to improve early drug development with a focus toward preclinical trials.
Academic pipeline programs are critical to effectively support the steady increase of diverse students entering the academy. Academic Pipeline Programs: Diversifying Bachelor's to the Professoriate describes best practices of successful academic government and privately funded pre-collegiate, collegiate, graduate, and postdoctoral/faculty development pipeline programs. The authors explore 21 hallmark academic pipeline programs using their THRIVE index: Type, History, Research, Inclusion, Identity, Voice, and Expectation. The final chapter of the book offers information for using and starting similar programs. The appendix offers an interactive Geographic Information System (GIS) mapped database of programs using the THRIVE index. This book will equip parents, high school counselors, college advisors, faculty, department chairs, and higher education administrators to identify academic pipeline programs that fit their needs. Readers will also learn about how academic pipeline programs are situated within an institutional or organizational change model.