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In the middle and late 1960s, when it was clear that neuroendocrinology was established as a discipline in its own right, it occurred to us that auto biographical accounts of the pioneer work in this field by the major par ticipants would provide a highly interesting and informative account of his tory in the making. With the death of G. W. Harris in late 1971, and the loss thereby of an outstanding pioneer and personality in neuroendocri nology, it appeared to us to be even more urgent to undertake such a ven ture and collect as many stories as possible. The three of us agreed that initially we would limit our invitations to the senior investigators whose re search careers lay mostly behind them, with the hope that if this venture proved successful, we could ask younger and still very active researchers in neuroendocrinology to contribute to a subsequent volume. Most of those invited to write for this book agreed to do so, but regrettably there remain some notable absentees. The authors were requested to write a personal, and even idiosyncratic, account of the steps taken, and the motivation and drive that led them to develop their interest in the relationship between the brain and the endocrine system.
In the middle and late 1960s, when it was clear that neuroendocrinology was established as a discipline in its own right, it occurred to us that auto biographical accounts of the pioneer work in this field by the major par ticipants would provide a highly interesting and informative account of his tory in the making. With the death of G. W. Harris in late 1971, and the loss thereby of an outstanding pioneer and personality in neuroendocri nology, it appeared to us to be even more urgent to undertake such a ven ture and collect as many stories as possible. The three of us agreed that initially we would limit our invitations to the senior investigators whose re search careers lay mostly behind them, with the hope that if this venture proved successful, we could ask younger and still very active researchers in neuroendocrinology to contribute to a subsequent volume. Most of those invited to write for this book agreed to do so, but regrettably there remain some notable absentees. The authors were requested to write a personal, and even idiosyncratic, account of the steps taken, and the motivation and drive that led them to develop their interest in the relationship between the brain and the endocrine system.
This book is designed as an introductory text in neuroendocrinology; the study of the interaction between the brain and endocrine system and the influence of this on behaviour. The endocrine glands, pituitary gland and hypothalamus and their interactions and hormones are discussed. The action of steroid and thyroid hormone receptors and the regulation of target cell response to hormones is examined. The function of neuropeptides is discussed with respect to the neuroendocrine system and behaviour. The neuroimmune system and lymphokines are described and the interaction between the neuroendocrine and neuroimmune systems discussed. Finally, methods for studying hormonal influences on behaviour are outlined. Each chapter has review and essay questions designed for advanced students and honours or graduate students with a background in neuroscience, respectively.
How does the brain regulate sexual behavior, or control our body weight? How do we cope with stress? Addressing these questions and many more besides, this thoroughly revised new edition reflects the significant advances that have been made in the study of neuroendocrinology over the last twenty years. The text examines the importance of the hypothalamus in regulating hormone secretion from the endocrine glands, describing novel sites of hormone release including bone, heart, skeletal muscle and liver. The role of steroid hormone, neurotransmitter and peptide receptors, and the molecular responses of target tissues, is integrated into the discussion of the neuroendocrine brain, especially through changes in gene expression. Particular attention is attached to neuropeptides, including their profound influence on behavior. Complete with new full-color figures throughout, along with review and essay questions for each chapter, this is an ideal resource for undergraduate and graduate students of neuroscience, psychology, biology and physiology.
70 years after the discovery of secretory neurons, internationally leading experts gathered to discuss the latest developments in neuropeptide research and endocrinology, concentrating on the molecular, cellular, supracellular and systemic aspects. A variety of neuropeptidergic systems are considered under comparative and evolutionary aspects.
o history of endocrinology can be written without reference N to Sir Humphry Davy Rolleston, whose monumental study of the subject appeared in 1936 under the modest subtitle: The Endocrine Organs in Health and Disease with an Historical Review. It was based on the author's Fitzpatrick Lectures at the Royal College of Physicians of London in 1933 and 1934. The lectureship, which dates from 1901, is devoted to the History of Medicine. Rolleston's work as regards scholarship and delivery cannot be surpassed and will remain the solid basis for any further study. It is of interest to note that Rolleston gave the Fitzpatrick Lectures when he was 71 years of age and had his book published when he was 74. By that time he had achieved most of his professional aims and all the honours a distinguished medical career can offer (see Section II). He perceived clearly that endocrinology was "an enormous subject in a most active stage of growth", which "recently has received most valuable help from organic chemists, who have devoted much time to the elucidation of the structure, isolation and synthesis of the hormones". He remarked that the knowledge of endocrinology was expanding with extreme rapidity, and it has been suggested that in this respect it would appear to be itself influenced by a growth hormone. He continued: "Before 1890 there were comparatively few publications dealing with the ductless glands, but in 1913, A.
Neuroendocrinology, Volume II, is the second in a two-volume treatise designed to provide a survey of all aspects of the rapidly expanding science of neuroendocrinology. Only in recent years have the relations between the nervous system and the endocrine system come under intensive scrutiny, but their interactions have already been shown to be multiple and diverse. This diversity is reflected in the range of subjects covered. There are chapters on neural control of endocrine function; the effects of hormones on the brain; brain-endocrine interrelations during various phases of development; and the comparative aspects of neuroendocrine integration. The relation of brain chemistry to endocrine function, the effect of drugs on neuroendocrine mechanisms, and the new discipline of clinical neuroendocrinology have also been considered. Not only neurophysiologists and endocrinologists, but pharmacologists, zoologists, biochemists, psychologists, and those in clinical medicine will find the treatise of interest. Parts of neuroendocrinology have been discussed in other works, but this is the first treatise in which an attempt has been made to cover all ramifications of neuroendocrinology. This book can be used both as a text for advanced students and as a reference source.
HIS book grew out of suggestions from the Publications Com T mittee of the American Physiological Society, which has planned a series covering the development of ideas about a number of areas of physiology. This was prompted by the great success of Circulation of the Blood: Men and Ideas, edited by A. P. Fishman and D. W. Richards, which was originally published in 1964 and then reissued by the Society in 1982. Three companion books are being completed in conjunction with the centennial year of the American Physiolog ical Society: this volume on endocrinology, one on the kidney, and one on membrane transport. It was our purpose not to provide a complete bibliography or a complete listing of all the progress made in a given area but to show PREFACE the principal ideas and how they developed. Consequently, limi- tions were placed on the number of references and on the length of each chapter. This book covers most of the areas of endocrinology; it is not completely comprehensive but discusses the main pathways of development and highlights the prominent investigators. We hope that the book as a whole will give an excellent picture of the evolution of this exciting area of physiology and the people involved in its growth. Most of the endocrine organs were discovered in antiquity by such early workers as Aristotle and Galen. The last endocrine gland to be discovered was the parathyroid in 1891 by Gley.