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Physiology: Past, Present and Future documents the proceedings of a symposium in honor of Yngve Zotterman held in the Department of Physiology, Medical School, University of Bristol on 11-12 July 1979. The idea for the symposium was spurred by the knowledge that Yngve would reach the age of 80 in September 1978 and the belief that he would welcome a meeting to celebrate his great age and achievement, in the company of some of his distinguished friends and collaborators. The symposium discussed advances in several branches of physiology. These include studies on C-fiber afferents in the viscera, skin, and deeper somatic tissues; touch and pain; tactile paths in the nervous systems of mammals; jaw reflexes evoked from the cerebral cortex; thermoreception; and temperature sensitivity of humans and monkeys. Also included are papers on taste cell transduction; how the sense of taste controls appetitive and instrumental behavior; and structural changes in the excitable membrane during excitation. The book concludes with a discussion on future trends, which begins with some challenging remarks by Yngve Zotterman. These remarks are then taken up and developed by the speakers.
This history of exercise physiology is written from a systems perspective. It examines the responses of key physiological systems to the conditions of acute and chronic exercise, as well as their coupling with integrative responses.
Integrated History and Philosophy of Science (iHPS) is commonly understood as the study of science from a combined historical and philosophical perspective. Yet, since its gradual formation as a research field, the question of how to suitably integrate both perspectives remains open. This volume presents cutting edge research from junior iHPS scholars, and in doing so provides a snapshot of current developments within the field, explores the connection between iHPS and other academic disciplines, and demonstrates some of the topics that are attracting the attention of scholars who will help define the future of iHPS.
This volume brings together important theoretical and methodological issues currently being debated in the field of history of education. The contributions shed insightful and critical light on the historiography of education, on issues of de-/colonization, on the historical development of the educational sciences and on the potentiality attached to the use of new and challenging source material.
This volume presents a broad panorama of the current status of research of invertebrate animals considered belonging to the phylum Cnidaria, such as hydra, jellyfish, sea anemone, and coral. In this book the Cnidarians are traced from the Earth’s primordial oceans, to their response to the warming and acidifying oceans. Due to the role of corals in the carbon and calcium cycles, various aspects of cnidarian calcification are discussed. The relation of the Cnidaria with Mankind is approached, in accordance with the Editors’ philosophy of bridging the artificial schism between science, arts and Humanities. Cnidarians' encounters with humans result in a broad spectrum of medical emergencies that are reviewed. The final section of the volume is devoted to the role of Hydra and Medusa in mythology and art.
**Selected for Doody's Core Titles® 2024 in Perinatal** Awarded first place in the 2018 AJN Book of the Year Awards in the Maternal-Child Health/Prenatal Nursing/ Childbirth category! Learn to provide the best prenatal, intrapartum, postpartum, and neonatal care possible. Maternal, Fetal, & Neonatal Physiology: A Clinical Perspective, 5th Edition includes expert insight and clinically relevant coverage of the physiologic changes that occur throughout all major periods of the perinatal experience. This classic reference gives you a solid foundation for assessment and therapeutic interventions, featuring an emphasis on the evolving interrelationships between mother, fetus, and neonate and adaptations of preterm and term infants to the extrauterine environment. - Solid coverage of the physiologic bases for assessment and therapeutic interventions make this an ideal resource for maternity, neonatal, women's health, or midwifery programs. - Synthesis of the latest research studies and evidence-based practice provides vital data on normal physiologic changes during the antepartum, intrapartum and postpartum periods; anatomic and functional development of the fetus; and developmental physiology of preterm and term neonates. - Coverage of pathophysiology and interventions for the pregnant woman, fetus, and newborn for selected abnormal events gives you a solid understanding of physiologic adaptations and developmental physiology relating to major body systems and metabolic processes. - Pharmacology tables offer quick access to key pharmacology information and drug effects with clinical examples. - NEW! Thoroughly updated content addresses the very latest practice issues and provides the basis for understanding physiologic adaptations in pregnant women, infants, and children. - NEW! Expanded coverage of maternal, fetal, neonatal, and pediatric physiology. - NEW! Soft cover and added color provide a contemporary look and feel.
Pioneering studies conducted in the 1980’s laid the foundation for the hypothesis that axonal regeneration is limited by CNS myelin, and the identification of myelin-associated glycoprotein (MAG), Nogo, and oligodendrocyte myelin glycoprotein (OMgp) as inhibitors of neurite outgrowth firmly established myelin as a key factor in regenerative failure. Mechanistically, it has been shown that MAG, Nogo, and OMgp mediate inhibition by binding to either Nogo receptor (NgR) or paired immunoglobulin receptor B (PirB), and initiating a signaling cascade that culminates in the activation of RhoA. Since the discovery of these proteins, there has been tremendous interest in identifying compounds and molecular mechanisms that are capable of overcoming myelin-mediated inhibition. Many studies have focused on pharmacological antagonism of receptors and signaling intermediates, while others have sought to identify and enhance endogenous pro-regenerative pathways. The most notable example of the latter is the conditioning lesion effect, which led to the discovery of cyclic AMP’s ability to overcome inhibition by MAG and myelin. Many of the agents tested in these studies have been shown to promote axonal regeneration in vivo, and this research topic allows researchers to share information about new treatments that have been developed in both academia and industry. As we look toward the future, it is becoming increasingly clear that reversal of myelin-mediated inhibition alone will not be sufficient to produce functional recovery from spinal cord injury, and that other factors, such as astroglial scarring, the expression of chondroitin sulfate proteoglycans, neuronal cell death, and lack of neurotrophic support, must also be taken into consideration. Combinatorial approaches therefore hold a great deal of promise, and we hope to initiate a dialogue on how stem cell transplantation, chondroitinase ABC, gene therapy, growth-promoting agents, and other methods can be combined to optimize functional recovery. We introduce this topic in honor of the life and work of Dr. Marie T. Filbin (1955-2014). Through these articles, we highlight past achievements in the field, novel findings, unanswered questions and innovative ideas that we hope will lead to new advances in axonal regeneration.