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This compendium summarizes published results of clinical observations and of more basic studies that help to elucidate the physiological mechanisms of adaptation of humans to prolonged bed rest. If the authors' abstract or summary was appropriate, it was included. In some cases a more detailed synopsis is provided, under the subheadings Purpose, Methods, Results, and Conclusions. This volume includes material published from 1981 through 1988.
Deconditioning is an integrated physiological response of the body to a reduction in metabolic rate, that is, to a reduction in energy use or in exercise level. Deconditioning and Reconditioning presents selected background information on the many aspects of ground-based and in-flight physiological research and applications. This multi-auth
Tens of thousands of miles above Earth's atmosphere, orbiting this planet like pieces from a child's giant erector set, NASA's massive International Space Station slowly takes shape. When completed, as many as 16 countries will provide crew members for this orbiting international community. But while this will not be the first extended stay of humans in space-Skylab, Mir Space Station, and Shuttle-Mir missions all involved extended-stay periods-it will give birth to some new questions about one of space exploration's biggest concerns: providing adequate nutrition essential to good physical and mental health in space. Nutrition in Spaceflight and Weightlessness Models consolidates nutritional observations from 38 years of human spaceflight. It is a compilation of nutritional knowledge and accomplishments from the early 1970's to the recent Shuttle-MIR program. It provides basic nutritional concepts, as well as broad coverage, of the effect of space and weightlessness on nutrition status and physiology. Nutrition in Spaceflight and Weightlessness Models addresses the utility of ground-based weightlessness simulations; the role of electrolytes, calcium, protein, iron, and micronutrients in optimal nutrition; and energy utilization by space crews. The book also explores regenerative life-support and food systems for space and planetary missions; the results of basic research in metabolism that illustrate the physiological changes that occur during spaceflight; new concepts and recommendations for astronaut nutrition in future spaceflights; and, the lab capabilities of the International Space Station.
The study of fatigue as a major focus in clinical practice and research is relatively new, but the editors argue that much more is known about it than most texts admit. Here two dozen essays and interviews represent the perspectives of clinically oriented people, who often go beyond the established
The purpose for this 30-day bed-rest study was to investigate the effects of short-term, high-intensity isotonic and isokinetic exercise training on maintenance of aerobic work capacity (peak oxygen uptake); muscular strength and endurance; and orthostatic tolerance, equilibrium, and gait. Other data were collected on muscle atrophy, bone mineralization and density, endocrine analyses of vasoactivity and fluid-electrolyte balance, muscle intermediary metabolism, and performance and mood of the subjects. Nineteen men (32-42 yr) were allocated into three groups: no-exercise control (peak oxygen uptake and isokinetic tests once/wk, N = 5), isotonic exercise training (electronic Quinton ergometer, supine, N = 7), and isokinetic exercise training (electronic Lido ergometer, supine, N = 7). The exercise training regimens were conducted near peak levels for 30 min in the morning and 30 min in the afternoon 5 d/wk. The protocol consisted of a 7-d ambulatory control period during which the subjects equilibrated on the standardized diet, 30 d of 6 degrees head-down bed rest, and a final 4.5 d of ambulatory recovery. Their diet consisted of commonly available fresh and frozen foods; mean caloric consumption of 2,678 +/- SE 75 kcal/d (control), 2,833 +/- SE 82 kcal/day (isotonic), and 2,890 +/- SE 75 kcal/d (isokinetic) resulted in mean weight losses during bed rest of 1.01 kg, 0.85 kg, and 0.0 kg, respectively. The results indicated that: (1) The subjects maintained a relatively stable mood, high morale, and high esprit de corps throughout the study. Scores improved in nearly all performance and mood tests in almost all the subjects. Isotonic training, as opposed to isokinetic exercise training, was associated with decreasing levels of psychological tension, concentration, and motivation, and with improvement in the quality of sleep. (2) Peak oxygen uptake was maintained during bed rest with isotonic exercise training; it was not maintained as well with isokinetic ( -9.0%) or no-exercise ( -18.2%) training. If a 9% reduction in aerobic power is acceptable, isokinetic exercise training could be used for maintenance of strength, endurance, and the reduced aerobic capacity in astronauts during flight. (3) In general, there were few decreases in strength or endurance of arm or leg muscles during bed rest, in spite of reduction in size (atrophy) of some leg muscles. (4) There was no effect of isotonic or isokinetic exercise training on orthostasis, because tilt-table tolerances were reduced similarly from 42-53 min to 30-34 min in the three groups following bed rest. (5) Bed rest resulted in significant decreases of postural stability and self-selected step length, stride length, and walking velocity, which were not influenced by either exercise training regimen. Pre-bed-rest responses were restored by the fourth day of recovery.