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Do you often lose your keys? You will find in this book the best strategy to find them, or at least the one deduced from statistical physics. What is the link with biology? Some proteins use the same strategy to find their target inside a living cell. This example illustrates one of the many links between physics and biology. These links result from an intense research activity in the past years at the interface between those two disciplines. This book describes some of the most recent progresses at this interface: from instrumental progresses used in biology to the mechanical description of a cell, to molecular motors, from brain activity mechanisms to auditory or sensory perception. Many fields are covered from the molecular to the scale at the organ level. A few biological notions are presented in the first chapter that may help to access the biological aspects of the others. In the end this book may interest people passionate in science, from the simple amateur to the advanced researcher level.
This textbook provides an integrated physical and biochemical foundation for undergraduate students majoring in biology or health sciences. It is particularly suitable for students planning to enter the pharmaceutical industry. This new generation of molecular biologists and biochemists will harness the tools and insights of physics and chemistry to exploit the emergence of genomics and systems-level information in biology, and will shape the future of medicine.
This book, first published in 2005, is a discussion for advanced physics students of how to use physics to model biological systems.
Schrodinger's riddle -- The quality of life -- Cells in nature and in theory -- Molecular logic -- A (almost) comprehensible cell -- It takes a cell to make a cell -- Morphogenesis: where form and function meet -- The advance of the microbes -- By descent with modification -- So what is life? -- Searching for the beginning.
The origins of life remains one of the great unsolved mysteries of science. Growing evidence suggests that the first organisms lived deep underground, in environments previously thought to be uninhabitable, and that microbes carried inside rocks have travelled between Earth and Mars. But the question remains: how can life spring into being from non-living chemicals? THE FIFTH MIRACLE reveals the remarkable new theories and discoveries that seem set to transform our understanding of life's role in the unfolding drama of the cosmos.
Traditionally, the natural sciences have been divided into two branches: the biological sciences and the physical sciences. Today, an increasing number of scientists are addressing problems lying at the intersection of the two. These problems are most often biological in nature, but examining them through the lens of the physical sciences can yield exciting results and opportunities. For example, one area producing effective cross-discipline research opportunities centers on the dynamics of systems. Equilibrium, multistability, and stochastic behavior-concepts familiar to physicists and chemists-are now being used to tackle issues associated with living systems such as adaptation, feedback, and emergent behavior. Research at the Intersection of the Physical and Life Sciences discusses how some of the most important scientific and societal challenges can be addressed, at least in part, by collaborative research that lies at the intersection of traditional disciplines, including biology, chemistry, and physics. This book describes how some of the mysteries of the biological world are being addressed using tools and techniques developed in the physical sciences, and identifies five areas of potentially transformative research. Work in these areas would have significant impact in both research and society at large by expanding our understanding of the physical world and by revealing new opportunities for advancing public health, technology, and stewardship of the environment. This book recommends several ways to accelerate such cross-discipline research. Many of these recommendations are directed toward those administering the faculties and resources of our great research institutions-and the stewards of our research funders, making this book an excellent resource for academic and research institutions, scientists, universities, and federal and private funding agencies.
Biological Physics focuses on new results in molecular motors, self-assembly, and single-molecule manipulation that have revolutionized the field in recent years, and integrates these topics with classical results. The text also provides foundational material for the emerging field of nanotechnology.
Seventy years ago, Erwin Schrödinger posed a profound question: 'What is life, and how did it emerge from non-life?' This problem has puzzled biologists and physical scientists ever since. Living things are hugely complex and have unique properties, such as self-maintenance and apparently purposeful behaviour which we do not see in inert matter. So how does chemistry give rise to biology? What could have led the first replicating molecules up such a path? Now, developments in the emerging field of 'systems chemistry' are unlocking the problem. Addy Pross shows how the different kind of stability that operates among replicating molecules results in a tendency for chemical systems to become more complex and acquire the properties of life. Strikingly, he demonstrates that Darwinian evolution is the biological expression of a deeper, well-defined chemical concept: the whole story from replicating molecules to complex life is one continuous process governed by an underlying physical principle. The gulf between biology and the physical sciences is finally becoming bridged. This new edition includes an Epilogue describing developments in the concepts of fundamental forms of stability discussed in the book, and their profound implications. Oxford Landmark Science books are 'must-read' classics of modern science writing which have crystallized big ideas, and shaped the way we think.