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This book examines the physical forces - fluid shear, stretch, and gravity that play a role in the physiology of tissues and cellular functions. It gives special attention to the influences of the flow of blood and exercise on the growth of blood vessels and the flow of interstitial fluid on bone formation. Pathological conditions are also presented, such as the lack of mechanical loading on bone and osteoporosis. For biotechnologists, the problem of cell susceptibility to agitation-induced hydrodynamic forces in the scale-up of mammalian cell bioreactors is examined.
A Top 25 CHOICE 2016 Title, and recipient of the CHOICE Outstanding Academic Title (OAT) Award. How much energy is released in ATP hydrolysis? How many mRNAs are in a cell? How genetically similar are two random people? What is faster, transcription or translation?Cell Biology by the Numbers explores these questions and dozens of others provid
A biological physics text for a multidisciplinary audience, exploring the architectural structure of the cell.
Developing organisms are systems in which the geometry, dynamics, and boundary conditions are all changing in the course of morphogenesis. The morphogenesis of cells and organisms appear to be mediated in part by the mechanically active components of the cytoskeleton. Mechanical forces have long been considered secondary to the effects of molecular mechanisms in cell growth, differentiation, and development. This volume explores the role of mechanical forces in cell growth and development and demonstrates its importance. This volume will prove invaluable to all biologists interested in the fundamentals of mechanical forces in development, from the advanced to the graduate researcher.
The NATO Advanced Study Institute on Biomechanics of Active Movement and Division of Cells was held September 19-29, 1993 in Istanbul and the Proceedings are presented in this volume. Sixty-eight scientists from sixteen countries attended. Prof. J. Bereiter-Hahn of Goethe-Universitat, Frankfurt, Germany, Prof. A.K. Harris of the University of North Carolina, Chapel Hill, USA, Prof. R.M. Nerem of Georgia Institute of Technology, Atlanta, USA and Prof. R. Skalak of the University of California, San Diego, USA were the members of the International Organizing Committee. As the Scientific Director of the Institute, I wish to express my sincere appreciation for their assistance without which the Institute could not have taken place. This Institute is the third one of the meetings which are now called "the NATO Istanbul Meetings on Cytomechanics". The first one was the NATO Advanced Research Workshop on Biomechanics of Cell Division which was held October 12-17, 1986 in Istanbul. The Proceedings were published as NATO ASI Series A Life Sciences Vol. 132 by Plenum Press in 1987. The second one was the NATO Advanced Study Institute on Biomechanics of Active Movement and Deformation of Cells which was held September 3-13, 1989 in Istanbul. The Proceedings were published as NATO ASI Series H : Cell Biology Vol. 42 by Springer-Verlag in 1990.
Animal Cell Technology: Products of Today, Prospects for Tomorrow is a collection of papers that discusses the advancement and future of biotechnology. The book presents a total of 164 materials that are organized into 22 sections. The coverage of the text includes the various methodologies involved in animal cell technology, such as post translational modifications; kinetics and modeling; and measurement and assay. The book also covers product safety and consistency testing; products from animal cells in culture; and apoptosis and cell biology. The text will be of great use to biologists, biotechnicians, and biological engineers. Readers who have an interest in the advancement of biotechnology will also benefit from the book.
There has been an explosion of research activity related to angiogenesis in recent years, and hundreds of laboratories worldwide are actively involved in many aspects of angiogenesiS. The literature on angiogenesis increases exponentially every year, and more than 16,000 peer-reviewed articles have been published the past 25 years, which are scattered in basic science and clinical journals. The complexity of the cascade of events leading to new vessel formation from preexisting ones has challenged scientists in cell biology, biochemistry, physiology, pharmacology, molecular biology, developmental biology, and other fields. With their multidisciplinary approach and the powerful new techniques that have been developed, the progress in understanding angiogenesis has been impressive indeed. Only 12 years ago the mention of an angiogenic factor caused skepticism. Today we have the complete amino-acid fiequence and their genes cloned for at least 9 angiogenic factors. Many laboratories are studying their role in angiogenesis, and several biotechnology firms have a keen interest in commercial developments relative to these molecules. The role of extracellular matrix components in angiogenesis and the interaction of endothelial cells with other cell types such as pericytes, smooth muscle cells, and inflammatory cells have been studied by other groups. This rapid expansion is the result of a realization that in many disease states a common underlying pathology is a derangement in angiogenesis.
A volume in the new Principles and Applications in Engineering series, Tissue Engineering provides an overview of the major physiologic systems of current interest to biomedical engineers: cardiovascular, endocrine, nervous, visual, auditory, gastrointestinal, and respiratory. It contains useful definitions, tables of basic physiologic data, and an introduction to the literature. Then, the book reviews the status of tissue engineering of specific organs, including bone marrow, skeletal muscle, and cartilage. Readers will acquire a good understanding of the engineering and cell biological fundamentals of tissue engineering and will develop ideas for further development of this emerging and important field.
The congress’s unique structure represents the two dimensions of technology and medicine: 13 themes on science and medical technologies intersect with five challenging main topics of medicine to create a maximum of synergy and integration of aspects on research, development and application. Each of the congress themes was chaired by two leading experts. The themes address specific topics of medicine and technology that provide multiple and excellent opportunities for exchanges.