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Natural products are the most successful source of drugs. Of the 877 small-molecule new chemical entities introduced between 1981 and 2002, roughly half were natural products, semi-synthetic natural product analogues or natural mimics. Chinese herbs (traditional Chinese medicines, TCMs) have been used for prevention and treatment of diseases for thousands years. It has been attracting intensive attention in the trends of back to nature. As herbal medicines, the conditions of growth, harvest time, process and storage etc. will undoubtedly affect the presence and concentration of the bioactive constituents, thus affecting their quality and efficacy. Up to date, there are few books focussing on the relationship, which is the bridge between TCM and modern medical science, of traditional clinic uses, pharmacological activities and quality control of Chinese herbs. Unfortunately, bioactive compounds in Chinese herbs are usually not or only partially known. Actually, the active compounds considered in Chinese herbs may be different according to their clinical indication. In addition, it is considered that the curative effect of Chinese herbs is an integrative result of a number of bioactive compounds. Therefore, how to control the quality is a big problem. We would like to discuss the quality control based on their traditional clinical uses and pharmacological activities in this book, which is the fundamental step towards developing and modernising such products into evidence based medicines. It will also help the peoples to understand TCMs in modern scientific angles. This book is designed primarily as a textbook for or adjunct to course in herbal remedies, food safety or quality control of herbs. It is also a professional reference whom is in the area of drug discovery, pharmaceutical analysis and food chemistry.
Annotation The second volume of this book series on the modern practice of Chinese medicine continues with the focus on evidence-based TCM research. It is even more focused than the preceding one ? providing detailed information about the best sources of herbal supply required for research and drug development purposes. Herbal supply has always been a major concern for TCM researchers because it is difficult to ensure that the supply is of the best quality. Another highlight of the book are the special reviews on the state of Good Agricultural Practice
The second volume of this book series on the modern practice of Chinese medicine continues with the focus on evidence-based TCM research. It is focused on detailed information about the best sources of herbal supply and its quality control required for research and drug development purposes. Herbal quality has always been a major concern for TCM researchers because it is difficult to know which is of the best quality. Some other popular topics are also entertained.
Quality Control and Evaluation of Herbal Drugs brings together current thinking and practices for evaluation of natural products and traditional medicines. The use of herbal medicine in therapeutics is on the rise in both developed and developing countries and this book facilitates the necessary development of quality standards for these medicines.This book elucidates on various challenges and opportunities for quality evaluation of herbal drugs with several integrated approaches including metabolomics, chemoprofiling, marker analysis, stability testing, good practices for manufacturing, clinical aspects, Ethnopharmacology and Ethnomedicine inspired drug development. Written by Prof. Pulok K Mukherjee, a leader in this field; the book highlights on various methods, techniques and approaches for evaluating the purity, quality, safety and efficacy of herbal drugs. Particular attention is paid to methods that assess these drugs’ activity, the compounds responsible and their underlying mechanisms of action. The book describes the quality control parameters followed in India and other countries, including Japan, China, Bangladesh, and other Asian countries, as well as the regulatory profiles of the European Union and North America. This book will be useful in bio-prospecting of natural products and traditional medicine-inspired drug discovery and development. Provides new information on the research and development of natural remedies - essential reading on the study and use of natural resources for preventative or healing purposes Brings together current thinking and practices in quality control and standardization of herbal drugs highlighting several integrated approaches for metabolomics, chemo-profiling and marker analysis Aids in developing knowledge of various techniques including macroscopy, microscopy, HPTLC, HPLC, LC-MS/MS, GC-MS etc. with the development of integrated methods for evaluation of botanicals used in traditional medicine Assessment of herbal drugs through bio-analytical techniques, bioassay guided isolation, enzyme inhibition, pharmacological, microbiological, antiviral assays and safety related quality issues References global organizations, such as the WHO, USFDA, CDSCO, AYUSH, TCM and others to serve as a comprehensive document for enforcement agencies, NGOs and regulatory authorities
Chinese Materia Medica - Chemistry, Pharmacology and Applications provides comprehensive and up-to-date information on the chemistry and pharmacology of commonly-used Chinese herbs. It gives an in-depth profile of the traditional experience of Chinese materia medica with modern scientific explanations. It also features the theories and concepts of Chinese materia medica from the Western medical perspectives, and the sources, production and quality control of Chinese materia medica. This book can be used both as a reference book and a textbook for specialized university and on-the-job training courses. It is essential reading for all students and practitioners of traditional Chinese medicine. It should also be of interest to those in education and research in natural products, pharmaceutical sciences and medicine.
Chinese Herbal Medicine -- part of a larger healing system called Traditional Chinese Medicine (TCM), which also includes acupuncture, massage dietary advice and exercise. TCM is a popular method of treatment -- is actually called Chinese Drug Therapy in China because it uses a wide variety of substances and therapeutic modalities. Plant, animal and mineral substances are all included in the Materia Medica of Chinese Drug Therapy. The earliest uses date back at least 4000 years to the Shang dynasty. Characters representing medicinal substances have been found carved into oracular bone fragments. These were used diagnostically by the Wu Shaman of this time. The earliest materia Medica, the Sheng Nung Peng Tsao, recorded over 10,000 medicinal substances. While there seems to be an almost unlimited amount of medicinal substances, the most commonly used number around 200. Increased attention has begun being given to the field due to several factors: The apparent success stories in many cases; The failure of Western medicine in many disorders; and Realisation on the part of Western researchers that successful drugs can be designed on the basis of Chinese herbal drugs. This new book presents the latest research in the field.
After the successful introduction of acupuncture to the West, recent advances in analytical methods in chemistry, molecular biology and systems biology – especially the development of the “omic” technologies – have again brought Chinese drugs into the focus of research on Traditional Chinese Medicine (TCM). With more than 1000 publications on the chemistry, molecular biology and pharmacology of TCM drugs in international journals over the last 10 years, Chinese drugs are gaining increasingly reputation and impact. These data offer great opportunities for the development of new pharmaceuticals for various clinical applications. International scientists have compiled relevant and trend setting research results in this book. Topics range from the latest methods of quality and safety assurance by chemical and genetic fingerprints to the development of new pharmaceuticals for a future evidence-based therapy e.g. for cancer, cardiovascular, inflammatory or infectious diseases as well as to recent experimental results on multitarget and synergy research for the preparation of multi-extract-pharmaceuticals from TCM.
Annals of Traditional Chinese Medicine is a new book series dedicated to the promotion of evidence-based TCM research. It features quality reports focusing on curriculum design, research methodology, original investigations of the quality, efficacy and safety of TCM, and evidence-based trials for the management of various clinical conditions.The inaugural volume of this series, Chinese Medicine — Modern Practice, contains chapters on Chinese Herbal Medicine (for AIDS, cancer, cardiovascular disease, cerebral haemorrhage and Alzheimer disease), Acupuncture (for drug withdrawal, anaesthesia and analgesia), Research Methodology and Chinese Medicine Education.The book will be of interest to clinicians in western medicine, mainstream medical researchers, other healthcare professionals, Chinese medicine educators, clinical and basic Chinese medicine researchers, and health science students, particularly Chinese medicine students. It will also be an important resource for TCM regulators to obtain reliable and critical information concerning the evaluation of quality, efficacy and safety of clinical modalities of Chinese medicine.
This book introduces the methodology for collection and identification of herbal materials, extraction and isolation of compounds from herbs, in vitro bioassay, in vivo animal test, toxicology, and clinical trials of herbal research. To fully understand and make the best use of herbal medicines requires the close combination of chemistry, biochemistry, biology, pharmacology, and clinical science. Although there are many books about traditional medicines research, they mostly focus on either chemical or pharmacological study results of certain plants. This book, however, covers the systematic study and analysis of herbal medicines in general – including chemical isolation and identification, bioassay and mechanism study, pharmacological experiment, and quality control of the raw plant material and end products.