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Introduction. Centrak Nervous System Stimulants. Antidepressants and Antinxienty Agent (Anxiolytic). Antipsychotic Agents and Hallucinogens. General Anaestetics. Hypnotics and Sedatives. Skeletal Muscle Relaxants. Tranquilizing Agents. Anticonvulsant Drugs. Analgesics (Narcotcs). Anpyertic Analgesics. Nonsteroidal Anti- Inflammatory Agents. Adrenergic Agents. Adrenergic Blocking Agents. Cardiovascular Agents. Histamines & Antihistaminic Agents. antitussives & Expectorants. Coagulants and Anticoagulants
This Fourth Edition has been thoroughly revised and updated to take account of international developments in pharaceutical chemistry and to maintain the position of Practical Pharmaceutical Chemistry as the leading University textbook in the field of pharaceutical analysis and quality control. Part 2 deals with physical techniques of analysis for more advanced courses. It gives a broad coverage of the most widely used techniques in quantative chromatography. The treatmentof spectroscopy and radiopharmaceuticals has also been increased. Thre are additional chapters on the contribution and role of physical methods of analysis in the various stages of drug development; and a series of workshop-style exercises, illustrating the application of spectroscopic techniques in structural elucidation and verification of identity. Users of the two volumes will welcome the internationalisation of the text, with examples based on drugs and dosage forms that are widespread and in commun use in human medicine in Britain, continental Europe and North America. Additionally there is some reference to veterinary pharmaceuticals where they provide appropriate examples.
Dr Alagarsamy's Textbook of Medicinal Chemistry is a much-awaited masterpiece in its arena. Targeted mainly to B. Pharm. students, this book will also be useful for M. Pharm. as well as M. Sc. organic chemistry and pharmaceutical chemistry students. It aims at eliminating the inadequacies in teaching and learning of medicinal chemistry by providing enormous information on all the topics in medicinal chemistry of synthetic drugs. Salient Features Contains clear classification, synthetic schemes, mode of action, metabolism, assay, pharmacological uses with the dose and structure–activity relationship (SAR) of the following classes of drugs: Drugs acting on inflammation Drugs acting on respiratory system Drugs acting on digestive system Drugs acting on blood and blood-forming organs Drugs acting on endocrine system Contains a complete section on chemotherapy and the various classes of chemotherapeutic agents. Also includes recent topics like anti-HIV agents Contains brief introduction about the physiological and pathophysiological conditions of diseases and their treatment under each topic Provides well-illustrated synthetic schemes and alternative synthetic routes for majority of drugs that help in quick and enhanced understanding of the subject Covers the syllabi of majority of Indian universities
Syllabus(As per ER 1991)Antiseptics and Disinfectants-Proflavine*, Benzalkonium chloride, Cetrimide, Phenol, chloroxylenol, Formaldehyde solution, Hexachlophene, Nitrofurantoin. Sulphonamides- Sulphadiazine, Sulphaguanidine, Phthalylsulphathaizole, Succinylsulphathiazole, Sulphadimethoxine, Sulphamethoxypyridazine, Co-trimoxazole, sulfacetamide* Antileprotic Drugs-Clofazimine, Thiambutosine, Dapsone*, solapsone, Anti-tubercular Drugs- Isoniazid*, PAS*, Streptomycin, Rifampicin, Ethambutol*, Thiacetazone, Ethionamide, cycloserine, pyrazinamide*. Antimoebic and Anthelmintic Drugs- Emetine, Metronidazole, Halogenated hydroxyquinolines, Diloxanide furoate, Paromomycin, Piperazine*, Mebendazole, D.E.C.* Antibiotics- Benzyl penicillin*, Phenoxy methyl penicillin*, Benzathine penicillin, Ampicillin*, Cloxacillin, Carbencicillin, Gentamicin, Neomycin, Erythromycin, Tetracycline, Cephalexin, Cephaloridine, Cephalothin, Griseofulvin, Chloramphenicol. Antifungal agents- Udecylenic acid, Tolnaftate, Nystatin, Amphotericin, Hamycin. Antimalarial Drugs-Chloroquine*, Amodiaquine, Primaquine, Proguanil, Pyrimethamine*, Quinine, Trimethoprim. Tranquilizers-Chlorpromazine*, Prochlorperazine, Trifluoperazine, Thiothixene, Haloperiodol*, Triperiodol, Oxypertine, Chlordizepoxide, Diazepam*, Lorazepam, Meprobamate. Hypnotics- Phenobarbitone*, Butobarbitone, Cylobarbitone, Nitrazepam, Glutethimide*, Methyprylon, Paraldehyde, Triclofosodium. General Anaesthetics-Halothane*, Cyclopropane*, Diethyl ether*, Methohexital sodium, Thiopecal sodium, Trichloroethylene . Antidepressant Drugs- Amitriptyline, Nortryptyline, Imperamine*, Phepelzine, Tranylcypromine. Analeptics- Theophylline, Caffeine*, Coramine*, Dextro-amphetamine.Adrenergic drugs- Adrenaline*, Noradrenaline, Isoprenaline*, Phenylephrine, Salbutamol, Terbutaline, Ephedrne*, Pseudoephedrine. Adrenergic antagonist- Tolazoline, Propranolol*, Practolol. Cholinergic Drugs- Neostigmine*, Pyridostigmine, Pralidoxime, Pilocarpine, Physostigmine*. Cholinergic Antagonists- Atropine*, Hyoscine, Homatropine, Propantheline*, Benztropine, Tropicamide, Biperiden*. Diuretic Drugs- Furosemide*, Chlorothiazide, Hydrochlorothiazidc*, Benzthiazide, Urea*, Mannitol*, Ethacrynic Acid. Cardiovascular Drugs- Ethylnitrite*, Glyceryl trinitrate, Alpha methyldopa, Guanethidine, Clofibrate, Quinidine. Hypoglycaemic Agents- Insulin, Chlorpropamide*, Tolbutamide, Glibenclamide, Phenformin*, Metformin. Coagulants and Anti coagulants- Heparin, Thrombin, Menadione*, Bisphydroxy-coumarin, Warfarin sodium. Local Anaesthetics- Lignocaine*, Procaine*, Benzocaine, Histamine and anti-Histaminic Agents- Histamine, Diphenhydramine*, Promethazine, Cyproheptadine, Mepyramine*, Pheniramine, Chlorpheniramine*, Analgesics and Anti-pyretics- Morphine, Pethidine, Codeine, Mathadone, Aspirin*, Paracetamol, Analgin, Dextropropoxphene, Pentazocine. Non-steriodal anti-inflammatory agents- Indomethacin*, Phenylbutazone*, Oxyphenbutazone, Ibuprofen. Thyroxine and Antithyroids- Thyroxine*, Methimazole, Methyl thiouracil, Propylthiouracil. Diagnostic Agents- Lopanoic Acid, Propyliodone, Sulfobromopthalein-sodium, Indigotindisulfonate, Indigo Carmine, Evans blue, Congo Red, Fluorescein sodium. Anticonvulsants, cardiac glycosides, Antiarrhythmic, Antihypertensives&Vitamins.Steroidal Drugs- Betamethasone, Cortisone, Hydrocortisone, Prednisolone, Progesterone, Testosterone, Oestradiol, Nandrolone. Anti-Neoplastic Drugs- Actinomycin, Azathioprie, Busulphan, Chloramubucil, Cisplatin, Cyclophosphamide, Daunorubicin Hydrochoride, Fluorouracil, Mercaptopurine, Methotrexate, Mytomycin.
An introduction to pharmaceutical chemistry for undergraduate pharmacy, chemistry and medicinal chemistry students. Essentials of Pharmaceutical Chemistry is a chemistry introduction that covers all of the core material necessary to provide an understanding of the basic chemistry of drug molecules. Now a core text on many university courses, it contains numerous worked examples and problems
Written by an author with more than 40 years of teaching experience in the field, Experiments in Pharmaceutical Chemistry, Second Edition responds to a critical classroom need for material on directed laboratory investigations in biological and pharmaceutical chemistry. This new edition supplies 75 experiments, expanding the range of topics to 22 major areas of pharmaceutical chemistry. These include biochemical groups, botanical classes important to pharmacy, and major drug classifications: Carbohydrates Lipids Proteins Enzymes Inorganics Vitamins Steroids Plant Acids Flavonoids Alkaloids Tannins Resins Glycosides Gums Balsams Volatile Oils Analgesics Anesthetics Sulfa Drugs (Sulfonamides) Psychotropic Drugs Antibiotics Nucleic Acids Sections contain introductions to basic concepts underlying the fields addressed and a specific bibliography relating to each field. Each experiment provides detailed instructions in a user-friendly format, and can be carried out, in most cases, without the need for expensive instrumentation. This comprehensive laboratory manual offers much-needed instructional material for teaching laboratory classes in pharmaceutical chemistry. The breadth of subject matter covered provides a variety of choices for structuring a laboratory course.
The definitive textbook on the chemical analysis of pharmaceutical drugs – fully revised and updated Introduction to Pharmaceutical Analytical Chemistry enables students to gain fundamental knowledge of the vital concepts, techniques and applications of the chemical analysis of pharmaceutical ingredients, final pharmaceutical products and drug substances in biological fluids. A unique emphasis on pharmaceutical laboratory practices, such as sample preparation and separation techniques, provides an efficient and practical educational framework for undergraduate studies in areas such as pharmaceutical sciences, analytical chemistry and forensic analysis. Suitable for foundational courses, this essential undergraduate text introduces the common analytical methods used in quantitative and qualitative chemical analysis of pharmaceuticals. This extensively revised second edition includes a new chapter on chemical analysis of biopharmaceuticals, which includes discussions on identification, purity testing and assay of peptide and protein-based formulations. Also new to this edition are improved colour illustrations and tables, a streamlined chapter structure and text revised for increased clarity and comprehension. Introduces the fundamental concepts of pharmaceutical analytical chemistry and statistics Presents a systematic investigation of pharmaceutical applications absent from other textbooks on the subject Examines various analytical techniques commonly used in pharmaceutical laboratories Provides practice problems, up-to-date practical examples and detailed illustrations Includes updated content aligned with the current European and United States Pharmacopeia regulations and guidelines Covering the analytical techniques and concepts necessary for pharmaceutical analytical chemistry, Introduction to Pharmaceutical Analytical Chemistry is ideally suited for students of chemical and pharmaceutical sciences as well as analytical chemists transitioning into the field of pharmaceutical analytical chemistry.