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The monographs in this volume summarize the safety data on 11 pesticides that could leave residues in food commodities. These pesticides are aminopyralid, atrazine, azinphos methyl, lamba-cyhalothrin, difenoconazole, dimethomorph, flusilazole, procymidone, profenofos, pyrimethanil and zoxamide. The data summarized in the toxicological monographs served as the basis for the acceptable daily intakes and acute reference doses that were established by the Meeting. This volume and previous volumes of JMPR toxicological evaluations, many of which were published in the FAO Plant Production and Protection Paperseries, contain information that is useful to companies that produce pesticides, government regulatory officers, industrial testing laboratories, toxicological laboratories and universities.
Many of the pesticides applied to food crops in this country are present in foods and may pose risks to human health. Current regulations are intended to protect the health of the general population by controlling pesticide use. This book explores whether the present regulatory approaches adequately protect infants and children, who may differ from adults in susceptibility and in dietary exposures to pesticide residues. The committee focuses on four major areas: Susceptibility: Are children more susceptible or less susceptible than adults to the effects of dietary exposure to pesticides? Exposure: What foods do infants and children eat, and which pesticides and how much of them are present in those foods? Is the current information on consumption and residues adequate to estimate exposure? Toxicity: Are toxicity tests in laboratory animals adequate to predict toxicity in human infants and children? Do the extent and type of toxicity of some chemicals vary by species and by age? Assessing risk: How is dietary exposure to pesticide residues associated with response? How can laboratory data on lifetime exposures of animals be used to derive meaningful estimates of risk to children? Does risk accumulate more rapidly during the early years of life? This book will be of interest to policymakers, administrators of research in the public and private sectors, toxicologists, pediatricians and other health professionals, and the pesticide industry.
This two-volume publication contains information on acceptable daily intakes (ADIs) and maximum residue levels, general principles for the evaluation of pesticides and the recommendations made at the 2005 Joint Meeting of the FAO Panel of Experts on Pesticide Residues in Food and the Environment (JMPR) and the WHO Core Assessment Group, which was held in Geneva, Switzerland in September 2005.
During the meeting the FAO Panel of Experts was responsible for reviewing pesticide use patterns (good agricultural practices), data on the chemistry and composition of pesticides and methods of analysis for pesticide residues and for estimating the maximum residue levels that might occur as a a result of the use of pesticides according to good agricultural practices. The WHO Core Assessment Group was responsible for reviewing toxicological and related data and for estimating, where possible, acceptable daily intakes (ADIs) of pesticides for humans. This report contains information on ADIs, maximum residue limits (MRLs) and general principles for the evaluation of pesticides. The supporting documents (on residues and toxicological evaluations) contain detailed monographs on these pesticides and include comments on analytical methods.