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Invasive fungal diseases have increased many fold over the past 50 years. Current treatment regimens typically require prolonged administration of antifungal medications that can have significant toxicity. Moreover, our present potent antifungal armamentarium fails to eradicate fungal pathogens from certain compromised hosts. Additionally, invasive fungal diseases continue to have unacceptably high mortality rates. A growing body of work has focused on the utility of vaccines and/or immunotherapy as a powerful tool in combating mycoses, either for the active treatment, as an adjuvant, or in the prevention of specific fungal pathogens. This Research Topic will detail the exciting progress in developing vaccines and immunotherapy for fungi.
"Emanuel Christ and Christoph Gantenbein together with their teaching staff and students at ETH Zurich expanded their research on building typology to four more metropolises, again in Europe, Latin America, and Asia. 180 buildings were analyzed over the past two years to find inspiration and models that can be adapted for the local context of any given city. Each example is documented with an image, site and floor plans, axonometric projection, key data, and a brief description. An introduction and four essays on the interaction between various protagonists and in particular the effect of governing local building regulation again show the potential for contemporary urban architecture. The result is again a rich sourcebook of great practical value for students, lecturers and practitioners of architecture." (Note de l'éditeur).