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Genetic factors have been proved to be involved in almost all dental and craniomaxillofacial diseases. Typical dental and craniomaxillofacial hereditary diseases refer to hereditary diseases which occurs in the oral and maxillofacial area, as well as systemic or other system hereditary diseases accompanied by oral abnormality. The former includes enamel hypoplasia, dentin hypoplasia and cleft lip and palate, which mainly occur in the oral cavity. While the latter commonly includes cranial clavicle hypoplasia, congenital ectodermal hypoplasia, osteogenesis imperfecta, and osteosclerosis. In addition, common diseases that appear locally in the oral cavity, including caries, periodontitis, oral mucosal diseases and head and neck tumors, are also considered to be related to genetic variations. With the increase of large-scale genome-wide association analysis study (GWAS) during the last decade, common loci for many genetic diseases have been identified. To date, most evidence comes from GWAS of dental caries and periodontal disease, which have tested associations between millions of single nucleotide polymorphisms (SNPs) and typical binary phenotypes. However, genetic loci for other rare oral diseases remain to be studied due to their large variety and low incidence. Multi-omics sequencing technology provides a more powerful tool for identifying the pathogenic genes of dental and craniomaxillofacial hereditary diseases at genomic, transcriptomic and proteomic level. In addition, with the development of single-cell multi-omics technology, specific cell populations involved in the pathogenesis of dental and craniomaxillofacial hereditary disease can be more accurately identified at single-cell resolution.
Craniofacial Development, the latest volume of Current Topics in Developmental Biology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in Craniofacial Development, and includes sections on such topics as microRNAs in craniofacial development and epigenetic regulation in craniofacial development. - Provides a comprehensive book on craniofacial development and tissue regeneration - Authored by leading experts in this field - Carefully organized to cover an array of topics critical in helping readers learn the most important aspects of craniofacial development and tissue regeneration
In this field there has been an explosion of information generated by scientific research. One of the beneficiaries of this has been the study of morphology, where new techniques and analyses have led to insights into a wide range of topics. Advances in genetics, histology, microstructure, biomechanics and morphometrics have allowed researchers to view teeth from alternative perspectives. However, there has been little communication between researchers in the different fields of dental research. This book brings together overviews on a wide range of dental topics linking genes, molecules and developmental mechanisms within an evolutionary framework. Written by the leading experts in the field, this book will stimulate co-operative research in fields as diverse as paleontology, molecular biology, developmental biology and functional morphology.
This follow-up to The Anthropology of Modern Human Teeth puts methods to use in interpreting human origins and affinities.
Biological Mechanisms of Tooth Movement, Second Edition is an authoritative reference to the scientific foundations underpinning clinical orthodontics. Led by an expert editor team and with contributions from an international group of contributors, the book covers key topics including bone biology, the effects of mechanical loading on tissues and cells, genetics, inflammation, tissue remodeling and the effects of diet, drugs, and systemic diseases. Highly-illustrated throughout, this second edition has been fully revised, updated and expanded to new developments in genomics, rapid orthodontics and current controversies in tooth movement research. Trainees, qualified specialists and researchers in orthodontics can rely on this comprehensive text to inform them about the clinical and scientific implications of the biological mechanisms involved in the movement of teeth.
Biological Mechanisms of Tooth Movement This new edition continues to be an authoritative reference to the scientific foundations underpinning clinical orthodontics The newly and thoroughly revised Third Edition of Biological Mechanisms of Tooth Movement delivers a comprehensive reference for orthodontic trainees and specialists. It is fully updated to include new chapters on personalized orthodontics as well as the inflammatory process occurring in the dental and paradental tissues. It is heavily illustrated throughout, making it easier for readers to understand and retain the information discussed within. The topics covered range from bone biology, the effects of mechanical loading on tissues and cells, genetics, tissue remodeling, and the effects of diet, drugs, and systemic diseases. The Third Edition of Biological Mechanisms of Tooth Movement features seven sections that cover subjects such as: The development of biological concepts in orthodontics, including the cellular and molecular biology behind orthodontic tooth movement Mechanics meets biology, including the effects of mechanical loading on hard and soft tissues and cells, and biological reactions to temporary anchorage devices Inflammation and orthodontics, including markers for tissue remodeling in the gingival crevicular fluid and saliva Personalized diagnosis and treatment based on genomic criteria, including the genetic influences on orthodontic tooth movement Rapid orthodontics, including methods to accelerate or decelerate orthodontic tooth movement Perfect for residents and PhD students of orthodontic and periodontal programs, Biological Mechanisms of Tooth Movement is also useful to academics, clinicians, bone biologists, and researchers with an interest in the mechanics and biology of tooth movement.
This book is open access under a CC BY 4.0 license. ​This handbook synthesizes and analyzes the growing knowledge base on life course health development (LCHD) from the prenatal period through emerging adulthood, with implications for clinical practice and public health. It presents LCHD as an innovative field with a sound theoretical framework for understanding wellness and disease from a lifespan perspective, replacing previous medical, biopsychosocial, and early genomic models of health. Interdisciplinary chapters discuss major health concerns (diabetes, obesity), important less-studied conditions (hearing, kidney health), and large-scale issues (nutrition, adversity) from a lifespan viewpoint. In addition, chapters address methodological approaches and challenges by analyzing existing measures, studies, and surveys. The book concludes with the editors’ research agenda that proposes priorities for future LCHD research and its application to health care practice and health policy. Topics featured in the Handbook include: The prenatal period and its effect on child obesity and metabolic outcomes. Pregnancy complications and their effect on women’s cardiovascular health. A multi-level approach for obesity prevention in children. Application of the LCHD framework to autism spectrum disorder. Socioeconomic disadvantage and its influence on health development across the lifespan. The importance of nutrition to optimal health development across the lifespan. The Handbook of Life Course Health Development is a must-have resource for researchers, clinicians/professionals, and graduate students in developmental psychology/science; maternal and child health; social work; health economics; educational policy and politics; and medical law as well as many interrelated subdisciplines in psychology, medicine, public health, mental health, education, social welfare, economics, sociology, and law.