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In this publication a comprehensive overview of the state of the art and future perspectives is given in the fields of basic research, diagnosis, therapy, suicide and relapse prevention, and psychiatric care regarding patients with affective disorders. Presented are decisive new developments which have been milestones in basic research or diagnosis, pharmacotherapy and psychotherapy of affective disorders. The contributions of renowned experts in the field include quantitative brain morphology and developments in genetics and neurochemistry. Special attention has been given to neuropharmacology, pharmacogenetics, electrophysiology, structural and functional neuroimaging of affective disorders as well as new therapeutic options in the field of psychotherapy. Moreover, important clinical issues such as modern aspects of preventing relapse, suicide and postnatal depression in mothers are discussed. Psychiatrists, psychotherapists, neurobiologists and students who participate in the treatment of patients with affective diseases will find this book valuable reading.
Biological research in the affective disorders has been an international growth industry for several years. Biological Aspects of Affective Disorders is a comprehensive introduction to the biochemical, pharmacological, and genetic aspects constituting the abnormalities that may underline the diseases of depression and mania, together with the current understanding of the clinical features and management of affected patients.It will be of great value especially to young researchers from all disciplines contributing to this area and to trainee psychiatrists.
In this publication a comprehensive overview of the state of the art and future perspectives is given in the fields of basic research, diagnosis, therapy, suicide and relapse prevention, and psychiatric care regarding patients with affective disorders. Presented are decisive new developments which have been milestones in basic research or diagnosis, pharmacotherapy and psychotherapy of affective disorders. The contributions of renowned experts in the field include quantitative brain morphology and developments in genetics and neurochemistry. Special attention has been given to neuropharmacology, pharmacogenetics, electrophysiology, structural and functional neuroimaging of affective disorders as well as new therapeutic options in the field of psychotherapy. Moreover, important clinical issues such as modern aspects of preventing relapse, suicide and postnatal depression in mothers are discussed. Psychiatrists, psychotherapists, neurobiologists and students who participate in the treatment of patients with affective diseases will find this book valuable reading.
1. epidemiology and the affective disorders 2. neurochemistry of depression 3. immunity and depression 4. thyroid function in depression 5. social psychiatry and affective disorders 6. nosology of affective disorders 7. diagnosis of depression 8. DSM III and depression 9. suicidal episodes and risk factors in children 10. suicide in adults 11. schizoaffective states 12. vagaries of the concept of atypical depression 13. involutional melancholia 14. bipolar affective disorder: review and update 15. psychiatric illness after childrebearing 16. mania: clinical manifestations and assessments 17. prevention of affective disorders 18. psychotherapy of depression 19. drug therapy of depression 20. drug therapy and depression in children 21. the relationship between tardive dyskinesia and affective disorders 22. convulsive therapy: A reappraisal 23. advances in lithium therapy.
Current evidence indicates that over two-thirds of mood disorders pursue a recurrent or chronic course. Yet much of the progress recorded in the field of mood disorders and their treatment has been in research into the acute phase of the illness. Hence there is a need for a volume that specifically addresses the special clinical problems encountered inthe recurrent forms of these disorders. The various chapters of this book embrace a wide range of topics, including etiology, course, and long-term treatment, integrative reviews, results of recent investigations, and clinical reports. In this respect, the contributions reflect currentconcepts, research, and clinical practice. We have endeavored to build a bridge between neurobiology and psychology and have covered both the psychotherapeutic and the psychopharmacologic aspects of mood disorders.
This volume is the third in a series on depressive illness. The first volume, entitled Phenomenology of Depressive Illness, is devoted to a de scription of depressive illness from a variety of perspectives that include those of the patient, the clinician, and the psychiatric researcher. It de scribes the major subtypes of depressive illness and places them in the context of the life cycle. The second volume in this series is entitled Models of Depres sive Disorders: Psychological, Biological, and Genetic Perspectives. This volume describes several major models of depressive disorders, in cluding genetic, cognitive, interpersonal, intrapsychic, and neurobio logical models. The third and fourth volumes deal with the biology of affective disorders in detail. These volumes are distinguished by a triaxial ap proach. In Volume III the biology of affective disorders is described from the perspective of individual transmitter systems and neurophysi ologic and biologic processes. In Volume IV the biology of depression is addressed from the vantage point of symptom components of de pression, and similarities and differences in the biology of depression are described compared to other psychiatric disorders with clinically overlapping features such as anxiety disorders or eating disorders. The effects on biology of comorbid conditions such as anxiety, personal ity disorders, alcoholism, and eating disorders are reviewed. These ap proaches incorporate issues of state versus trait.
"As a psychotherapist and educator of future mental health practitioners, I believe this work fills an important gap in reference books for professionals who care for childbearing women. Since the volume provides invaluable neurobiological research on depression and anxiety, I recommend this work to all health and mental health professionals."--Illness, Crisis and Loss Over the past three years, pregnancy related mood disorders have become the focus of health care advocates and legislators alike with subsequent reflection in nationwide media. Statistics on the prevalence of perinatal mood disorders suggest that up to 20% of women experience diagnosable pregnancy related mood disorders. The growing recognition of these common disorders, coupled with an increasing knowledge base about the dire consequences of untreated maternal depression, has propelled this issue to the fore of national public health priorities. This increasing awareness has also resulted in recent legislative and healthcare initiatives to screen, assess, and treat such disorders. On April 13, 2006, Governor Jon S. Corzine (D -NJ) signed a law requiring all new mothers to be educated and screened for postpartum depression. This law is the first of its kind in the country, but many states and federal advocates are proposing similar laws. The motivation for states and the federal government to adopt education and screening program is high and may soon be a federal mandate. But a major barrier to successful implementation of such programs is the lack of available resources to train healthcare professionals in this specialty. This book offers a major resource for healthcare professionals, mental health professionals, and medical, nursing, psychology, and social work students who will be confronting this problem in their practices. The contributions, by renowned experts, fill a glaring gap in the knowledge professionals need in order to successfully manage maternal mental health.
First published in 1994. Routledge is an imprint of Taylor & Francis, an informa company.
Bipolar Disorder Vulnerability: Perspectives from Pediatric and High-Risk Populations synthesizes our current understanding of high-risk and pediatric populations to aid readers in identifying markers of vulnerability for the development of bipolar disorder, with an ultimate goal of the development of drug targets and other therapies for early diagnosis and treatment. The book provides readers with an understanding of biological and environmental factors influencing disease manifestation that will aid them in defining discrete clinical stages and, importantly, establish an empirical basis for the application of novel therapeutics in a phase of illness during which specific treatments could more effectively alter disease course. Whereas most of the literature available on the pathophysiological mechanisms of bipolar disorder focuses on chronically ill adult individuals, this represents the only book that specifically examines pediatric and high-risk populations. An estimated 30 to 60 percent of adult bipolar disorder patients have their disease onset during childhood, with early-onset cases representing a particularly severe and genetically loaded form of the illness. Highlights diverse translational methodologies, including functional and structural neuroimaging, neuropsychological testing and integrated genomics Examines molecular trajectories in youth with bipolar disorder and unaffected youth at high risk for developing bipolar disorder Explores the interaction between genomic and environmental influences that shape behavior