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Tetsunao Yamamori offers practical and visionary methods to equip missions-minded Christians to take the gospel into politically or culturally closed nations.
It all started when Ralph Winter gave an address at Lausanne called “The Unfinished Task,” urging the missions world to focus on a new type of evangelism to reach “hidden” or “unreached” peoples. Soon he and his wife Roberta were founding a center to help mission agencies fulfill that task. Around them gathered a group of experienced missionaries, computer scientists, and unusually dedicated young people in order to buy a college campus. This story, as told by Roberta, of their cliff-hanging prayer meetings and spiritual battles with a cult will reignite your determination to work with Jesus to “finish the Father’s work” (John 4). This new edition includes previously unpublished chapters from her original manuscript, and an updated epilogue inviting you to partner with the USCWM today, as the task remains unfinished. Don’t read this story unless you’re willing to have your horizons stretched, your faith tested, and your future disturbed!
In this book, a summary and update of the most important areas of cell-penetrating peptides (CPP) research are presented, while raising relevant questions for further development. The CPP sequences are presented and discussed throughout the book. The methods for testing CPP mechanisms are discussed in detail. Various approaches for the testing of endocytotic pathways of CPP uptake are also described. Different CPP uptake experiments are compared since it is becoming clear that it is often best to apply several methods in a complementary manner in order to most comprehensively evaluate CPP uptake mechanisms due to the complexity of these processes. A brief summary of functionality issues of CPPs, both in vitro and in vivo, is discussed. Therapeutic potential of CPPs and commercial developments are discussed. The present, second edition of this book is the updated and expanded version of the first edition, published in 2019. The development of the field of cell-penetrating peptides in these five years has been obvious and exciting. This second edition of the book has been partly reorganized and comprehensively expanded with the exciting research in 2019-2023. Around 2500 novel scientific articles have become available, most of them are reviewed in the second edition. Additional rapidly growing areas of high impact presented in this second edition are therapeutic developments (Chapter 16) and delivery of oligonucleotides and proteins/peptides (Chapters 5 and 6) including novel reports on genome editing with CPP assistance. Also, several additional examples are available now on clinical trials using CPPs (Chapter 15). The book is written for researchers and students in the field.
Frontiers in Offshore Geotechnics III comprises the contributions presented at the Third International Symposium on Frontiers in Offshore Geotechnics (ISFOG, Oslo, Norway, 10-12 June 2015), organised by the Norwegian Geotechnical Institute (NGI). The papers address current and emerging geotechnical engineering challenges facing those working in off
Cell-Penetrating Peptides The definitive reference on the rational design of cell-penetrating peptides enables readers to develop tailor-made peptides for their specific needs. In recent years, cell-penetrating peptides (CPPs) have become valuable tools for the cellular delivery of proteins, nucleic acids, and drugs. These small peptide sequences can be artificially designed and synthesized with custom-made characteristics to mediate the efficient and non-toxic transport of biomolecules, drugs, or nanoparticles into the cell. Cell-Penetrating Peptides: Design, Development, and Applications provides an up-to-date account of the development and use of CPPs for delivering membrane-impermeable bioactive molecules into cells. Bringing together contributions from leading researchers from around the world, this comprehensive volume describes the characteristics and mechanisms of CPPs as well as their application in both medicine, biotechnology and agriculture. Covers rational design and development of cell-penetrating peptides for use in cellular delivery of small molecule drugs, proteins, nucleic acids, and nanoparticles Presents the chemical and biological characteristics of CPP action in vitro and in vivo Describes the structure and design principles of both synthetic and naturally occurring CPPs Discusses key medical applications of CPPs such as oral delivery, intranasal delivery, and clinical trials Cell-Penetrating Peptides: Design, Development, and Applications is an essential resource for biochemists, medicinal chemists, molecular biologists, biotechnologists, and researchers studying CPPs in both academia and industry.
Tracing the intersections between archival documents and immensely popular adventure fiction set in Africa, Penetrating Critiques highlights the anxieties surrounding the vulnerability of the white male body by assessing the destabilization of narrative itself. The author considers texts ranging from private letters, governmental correspondence, periodicals, and archival documents to the popular works of H. Rider Haggard, Richard Marsh, and Joseph Conrad. These texts trouble the notions of bounded male bodies, impermeable histories, and solid virtues while underscoring the grotesqueness of male forms, narratives, and moralities. Although dominant representations of martial bodies frequently emphasized boundaries, containment, and solidity, the fiction and imperial archives explored in this book expose problems of stability through tropes, images, and material evidence of perforation, penetration, and dissolution. In emphasizing the relationship between institutional imperial writing and popular discourse, Penetrating Critiques reveals that more complex, fraught, and critical approaches to imperialism and masculinity were circulating throughout Victorian culture than previously recognized.