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This book provides a comprehensive, state-of-the art review of pediatric oncology. The text covers relevant concepts in molecular biology and addresses technical principles, applications, challenges, and integration of current and emerging genomic and molecular methods in the diagnosis and personalized management of childhood cancers. The text also discusses a wide array of pediatric neoplasms in the context of molecular pathology in a concise and understandable manner, with focus on their molecular pathogenesis, clinicopathological features, classification, molecular diagnosis, and approaches to personalized care. Written by experts in the field, Precision Molecular Pathology of Neoplastic Pediatric Diseases serves as a valuable resource for pathologists, pediatric oncologists, trainees and researchers with an interest in pediatric and molecular pathology.
Pediatric Neoplasia: Advances in Molecular Pathology and Translational Medicine presents many of the major, relevant advances in molecular pathology that are occurring in the field of pediatric oncology and will serve as a useful overview for resident and attending physicians as well as scientists interested in understanding the molecular pathology of pediatric cancer in the context of clinical medicine. Chapters are based upon organ systems, and each is written by an expert or pair of experts in their field with subspecialty training and extensive clinical experience. Each chapter describes a variable number of tumors and includes an overview of the classification system and clinicopathological characteristics of each tumor. This is followed by a discussion of the molecular pathology relevant to a specific tumor, including specific molecular markers of the tumors, methods used for diagnosis or clinical management, clinical significance of the markers, and if appropriate, a description or discussion of current activities in translational research or issues that need to be addressed in the future. Pediatric Neoplasia: Advances in Molecular Pathology and Translational Medicine will be of great value to pathologists, oncologists, hematologists, internal medicine and pediatric specialists, as well as pharmaceutical professionals and translational and clinical researchers.
Clearly presents the pathology of heart disease from fetus to adolescence, integrating histology and macroscopy with effects of treatment.
This volume provides a balanced and realistic review of the current state of glioblastoma, ranging from traditional histological review, molecular pathology of glioma, modern radiomics, neurosurgical focus, and integration of treatment plans by neuro-oncologists. The book reviews basic principles such as epidemiology and etiology, and modern 2016 WHO classification of CNS tumors. Chapters cover a general overview of common molecular techniques used in molecular pathology, molecular pathology in a developing country, key drivers of patient outcomes and predictors of response to radiation and/or chemotherapy treatment, and immunohistochemical surrogates for key molecular pathology. It concludes with reviews on radiomics, animal and stem cell models of glioblastoma, and a chapter on the emerging field of Glioblastoma Neuroscience. Precision Molecular Pathology of Glioblastoma is intended for pathology residents and fellows interested in glioblastoma, general surgical pathologists who need reviews on how to implement modern glioblastoma classification, as well as neuro-radiologists, oncologists, and radiation oncologists needing a holistic perspective to glioblastoma diagnosis and management.
Revised and updated for its Third Edition, Stocker and Dehner's Pediatric Pathology provides encyclopedic coverage of the diagnosis of pediatric disorders from the neonatal period through adolescence. It covers all major aspects of the pathologic anatomy of childhood disorders ranging from chromosomal syndromes and neoplasms to forensic pathology. Sections are organized by disease classification and by organ system. The book contains more than 1,300 gross and microscopic images, including 1,200 in full color. This edition includes a new chapter on transplantation pathology. Other highlights include significant updates in the areas of pediatric autopsy, imaging techniques, molecular techniques, embryonic and fetal wastage, congenital abnormalities, metabolic disorders, SIDS and forensic pathology, the placenta, and the nervous system.
Biochemical and Molecular Basis of Pediatric Disease, Fifth Edition has been a well-respected reference in the field for decades. This revision continues the strong focus on understanding the pathogenesis of pediatric disease, emphasizing not only the important role of the clinical laboratory in defining parameters that change with the disease process, but also the molecular basis of many pediatric diseases. Provides a fully-updated resource with more color illustrations Focuses on the biochemical and molecular basis of disease as well as the analytical techniques Defines important differences in the pathophysiology of diseases, comparing childhood with adult
This issue of Surgical Pathology Clinics, guest edited by Dr. Jessica Davis, is devoted to Challenges & Updates in Pediatric Pathology. Articles in this issue include: Advances and Pitfalls in the Diagnosis of Hirschsprungs Disease, Updates in Pediatric Enteropathies: Differential Diagnosis, Testing, and Genetics, Pediatric Liver Tumors: Updates in Classification, New Prognostic Indicators in Pediatric Adrenal Tumors: Neuroblastoma & Adrenal Cortical Tumors, Pediatric Cystic Lung Lesions, Strategies for the Neonatal Lung Biopsy: Histology to Genetics, Wilm’s Tumor: Challenges and Newcomers in Prognosis, Pediatric Renal Tumors: Updates in the Molecular Era, Newcomers in Vascular Anomalies, Spindle Cell Rhabdomyosarcoma: Further Subcategorization, Pediatric & Infantile Fibroblastic/myofibroblastic Tumors in the Molecular Era, Round Cell Sarcomas: Newcomers and Diagnostic Approaches, CNS Embryonal Tumors: Testing Strategies for Integrated Diagnosis, Updates in Pediatric Gliomas, and more.
Pediatric pathology has been a recognized sup-specialty of pathology for almost two decades. Today pathology training programs are required to provide education in pediatric pathology. In addition to pediatric pathology specialists, many general and community-based pathologists regularly handle pediatric specimens. A working knowledge of current pediatric pathology is essential for appropriate handling of these cases. The Color Atlas of Pediatric Pathology covers the broad range of pediatric diseases that a pathologist will likely encounter and is written by well-known leaders in this field. Coverage includes both frequent and less commonly seen cases, and each discussion presents a concise summary of the salient features of the disease along with expertly selected, high-quality color images. The Color Atlas of Pediatric Pathology is a practical working resource for every pathologist who sees pediatric cases as well as the pathology trainee. The atlas features approximately 1,100 high-quality images as well as important staging and prognostic (including molecular) parameters. Features of the Color Atlas of Pediatric Pathology include: Comprehensive coverage of pediatric surgical and autopsy pathology Each chapter is presented by a recognized expert Practical presentation: concise text highlights diagnostic features making the atlas an outstanding resource for the practitioner Illustrated throughout with approximately 1,100 full-color images