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Paul Ehrlich's Receptor Immunology: The Magnificent Obsession describes the background to Paul Ehrlich's immunological works and theories and delves into the substance of his experiments in great detail. By exploring these early developments in immunology, the book lays the foundation for modern concepts, providing immunologists, biomedical researchers, and students the context for the discoveries in their field. The selectionist theory of antibody formation Kinetics of primary and secondary antibody response Quantitative methods of measurement of antigens and antibody Demonstration of passive transfer of immunity from mother to foetus
In this innovative, short, new textbook, Rod Langman offers a conceptual framework within which students can understand the evolution of the immune system. Evolutionary selection for resistance to infectious disease is shown to be the driving force that has shaped the immune system into a remarkably effective and efficient system of defense. In the midst of the current information explosion in immunological science, when many students are under the impression that the immune system is almost too complex to understand as a whole, The Immune System can be used alone as a text for an introductory course or used in conjunction with any of the several descriptive texts already on the market.
Around Christmas of 1882, while peering through a microscope at starfish larvae in which he had inserted tiny thorns, Russian zoologist Elie Metchnikoff had a brilliant insight: what if the mobile cells he saw gathering around the thorns were nothing but a healing force in action? Metchnikoff's daring theory of immunity—that voracious cells he called phagocytes formed the first line of defense against invading bacteria—would eventually earn the scientist a Nobel Prize, shared with his archrival, as well as the unofficial moniker "Father of Natural Immunity." But first he had to win over skeptics, especially those who called his theory "an oriental fairy tale." Using previously inaccessible archival materials, author Luba Vikhanski chronicles Metchnikoff's remarkable life and discoveries in the first moder n biography of this hero of medicine. Metchnikoff was a towering figure in the scientific community of the early twentieth century, a tireless humanitarian who, while working at the Pasteur Institute in Paris, also strived to curb the spread of cholera, syphilis, and other deadly diseases. In his later years, he startled the world with controversial theories on longevity, launching a global craze for yogurt, and pioneered research into gut microbes and aging. Though Metchnikoff was largely forgotten for nearly a hundred years, Vikhanski documents a remarkable revival of interest in his ideas on immunity and on the gut flora in the science of the twenty-first century.
In 1901 Emil von Behring received the first Nobel Prize in med. for serum therapy against diphtheria, a disease that killed thousands of infants annually. Diphtheria serum was the first major cure of the bacteriological era and its develop. generated procedures for testing, standardizing, and regulating drugs. Emphasizes Behring's contrib. to the study of infectious disease, the formation of modern immunology, and research on remedies and vaccines against microbial infections. Explores his relations to the rival bacteriological schools of Robert Koch and Louis Pasteur, the emergent German pharmaceutical industry, and the institutionalization of experimental therapeutic research. Also contains translations of 13 key articles by Behring and his assoc.
A Historical Perspective on Evidence-Based Immunology focuses on the results of hypothesis-driven, controlled scientific experiments that have led to the current understanding of immunological principles. The text helps beginning students in biomedical disciplines understand the basis of immunologic knowledge, while also helping more advanced students gain further insights. The book serves as a crucial reference for researchers studying the evolution of ideas and scientific methods, including fundamental insights on immunologic tolerance, interactions of lymphocytes with antigen TCR and BCR, the generation of diversity and mechanism of tolerance of T cells and B cells, the first cytokines, the concept of autoimmunity, the identification of NK cells as a unique cell type, the structure of antibody molecules and identification of Fab and Fc regions, and dendritic cells. Provides a complete review of the hypothesis-driven, controlled scientific experiments that have led to our current understanding of immunological principles Explains the types of experiments that were performed and how the interpretation of the experiments altered the understanding of immunology Presents concepts such as the division of lymphocytes into functionally different populations in their historical context Includes fundamental insights on immunologic tolerance, interactions of lymphocytes with antigen TCR and BCR, and the generation of diversity and mechanism of tolerance of T and B cells
Examines medical history in northern Europe from 1850 to 2015 and sheds new light on the circulation of medical knowledge in that region