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It has been recognized for almost 200 years that certain families seem to inherit cancer. It is only in the past decade, however, that molecular genetics and epidemiology have combined to define the role of inheritance in cancer more clearly, and to identify some of the genes involved. The causative genes can be tracked through cancer-prone families via genetic linkage and positional cloning. Several of the genes discovered have subsequently been proved to play critical roles in normal growth and development. There are also implications for the families themselves in terms of genetic testing with its attendant dilemmas, if it is not clear that useful action will result. The chapters in The Genetics of Cancer illustrate what has already been achieved and take a critical look at the future directions of this research and its potential clinical applications.
All mothers hear this: "Tell me a story." The greatest stories they have to share are the ones about being mothers. Mothers have lessons to share with their children, their friends, spouses and even strangers. This collection of short stories is told from the viewpoint of more than a dozen different mothers from all backgrounds: they were born in different countries, with different traditions, different paths to motherhood, and different advice. The common theme they all share is their motherhood. The stories include: •Birthing from the Heart, the adoption memory of Alison Rand; •A Love Letter to My Daughter about becoming a mother for the first time, by Brita Moe; •All Little Ants Need Their Mother, about Valerie Nifora's Greek immigrant mother and a world of possibilities; •Creando Una Casa, Nancy Brooker's memories of the food and smells of her Italian mother's home; •Share, where a medical diagnosis gifted Cori Edwards with her mother's stories of growing up; •Motherhood Awakens Divine Power, Intuition and Consciousness, where Whitney Mullings transforms her family from the rigor of her Chinese roots to something that nurtures them all; and more. The advice of these authors works for new moms and mothers ready to share their memories alike; they cover topics like adoption, blended families, immigration stories, and post-partum depression. The stories inside touch on acceptance, worthiness, struggle, triumph, love, family and peace. Whether you are a mother yourself or have a strong bond with your own mother, the memories within this collection will resonate with you and inspire you.
How tiny variations in our personal DNA can determine how we look, how we behave, how we get sick, and how we get well. News stories report almost daily on the remarkable progress scientists are making in unraveling the genetic basis of disease and behavior. Meanwhile, new technologies are rapidly reducing the cost of reading someone's personal DNA (all six billion letters of it). Within the next ten years, hospitals may present parents with their newborn's complete DNA code along with her footprints and APGAR score. In Genetic Twists of Fate, distinguished geneticists Stanley Fields and Mark Johnston help us make sense of the genetic revolution that is upon us. Fields and Johnston tell real life stories that hinge on the inheritance of one tiny change rather than another in an individual's DNA: a mother wrongly accused of poisoning her young son when the true killer was a genetic disorder; the screen siren who could no longer remember her lines because of Alzheimer's disease; and the president who was treated with rat poison to prevent another heart attack. In an engaging and accessible style, Fields and Johnston explain what our personal DNA code is, how a few differences in its long list of DNA letters makes each of us unique, and how that code influences our appearance, our behavior, and our risk for such common diseases as diabetes or cancer.
A “must-read . . . gorgeous and intimate” novel that demystifies the idea of the selfless Japanese mother and the adult daughter honor-bound to care for her (Washington Post) Mitsuki Katsura, a Japanese woman in her mid-50s, is a French-language instructor at a private university in Tokyo. Her husband, whom she met in Paris, is a professor at another private university. He is having an affair with a much younger woman. In addition to her husband’s infidelity, Mitsuki must deal with her ailing 80-something mother, a demanding, self-absorbed woman who is far from the image of the patient, self-sacrificing Japanese matriarch. Mitsuki finds herself dreaming of the day when her mother will finally pass on. While doing everything she can to ensure her mother’s happiness, she grows weary of the responsibilities of a doting daughter and worries she is sacrificing her chance to find fulfillment in her middle age. Inheritance from Mother not only offers insight into a complex and paradoxical culture, but is also a profound work about mothers and daughters, marriage, old age, and the resilience of women.
2019 PEN/E.O. Wilson Literary Science Writing Award Finalist "Science book of the year"—The Guardian One of New York Times 100 Notable Books for 2018 One of Publishers Weekly's Top Ten Books of 2018 One of Kirkus's Best Books of 2018 One of Mental Floss's Best Books of 2018 One of Science Friday's Best Science Books of 2018 “Extraordinary”—New York Times Book Review "Magisterial"—The Atlantic "Engrossing"—Wired "Leading contender as the most outstanding nonfiction work of the year"—Minneapolis Star-Tribune Celebrated New York Times columnist and science writer Carl Zimmer presents a profoundly original perspective on what we pass along from generation to generation. Charles Darwin played a crucial part in turning heredity into a scientific question, and yet he failed spectacularly to answer it. The birth of genetics in the early 1900s seemed to do precisely that. Gradually, people translated their old notions about heredity into a language of genes. As the technology for studying genes became cheaper, millions of people ordered genetic tests to link themselves to missing parents, to distant ancestors, to ethnic identities... But, Zimmer writes, “Each of us carries an amalgam of fragments of DNA, stitched together from some of our many ancestors. Each piece has its own ancestry, traveling a different path back through human history. A particular fragment may sometimes be cause for worry, but most of our DNA influences who we are—our appearance, our height, our penchants—in inconceivably subtle ways.” Heredity isn’t just about genes that pass from parent to child. Heredity continues within our own bodies, as a single cell gives rise to trillions of cells that make up our bodies. We say we inherit genes from our ancestors—using a word that once referred to kingdoms and estates—but we inherit other things that matter as much or more to our lives, from microbes to technologies we use to make life more comfortable. We need a new definition of what heredity is and, through Carl Zimmer’s lucid exposition and storytelling, this resounding tour de force delivers it. Weaving historical and current scientific research, his own experience with his two daughters, and the kind of original reporting expected of one of the world’s best science journalists, Zimmer ultimately unpacks urgent bioethical quandaries arising from new biomedical technologies, but also long-standing presumptions about who we really are and what we can pass on to future generations.
A memoir by American former actress and singer Jennette McCurdy about her career as a child actress and her difficult relationship with her abusive mother who died in 2013
White Like Her: My Family’s Story of Race and Racial Passing is the story of Gail Lukasik’s mother’s “passing,” Gail’s struggle with the shame of her mother’s choice, and her subsequent journey of self-discovery and redemption. In the historical context of the Jim Crow South, Gail explores her mother’s decision to pass, how she hid her secret even from her own husband, and the price she paid for choosing whiteness. Haunted by her mother’s fear and shame, Gail embarks on a quest to uncover her mother’s racial lineage, tracing her family back to eighteenth-century colonial Louisiana. In coming to terms with her decision to publicly out her mother, Gail changed how she looks at race and heritage. With a foreword written by Kenyatta Berry, host of PBS's Genealogy Roadshow, this unique and fascinating story of coming to terms with oneself breaks down barriers.
Decades of research have demonstrated that the parent-child dyad and the environment of the familyâ€"which includes all primary caregiversâ€"are at the foundation of children's well- being and healthy development. From birth, children are learning and rely on parents and the other caregivers in their lives to protect and care for them. The impact of parents may never be greater than during the earliest years of life, when a child's brain is rapidly developing and when nearly all of her or his experiences are created and shaped by parents and the family environment. Parents help children build and refine their knowledge and skills, charting a trajectory for their health and well-being during childhood and beyond. The experience of parenting also impacts parents themselves. For instance, parenting can enrich and give focus to parents' lives; generate stress or calm; and create any number of emotions, including feelings of happiness, sadness, fulfillment, and anger. Parenting of young children today takes place in the context of significant ongoing developments. These include: a rapidly growing body of science on early childhood, increases in funding for programs and services for families, changing demographics of the U.S. population, and greater diversity of family structure. Additionally, parenting is increasingly being shaped by technology and increased access to information about parenting. Parenting Matters identifies parenting knowledge, attitudes, and practices associated with positive developmental outcomes in children ages 0-8; universal/preventive and targeted strategies used in a variety of settings that have been effective with parents of young children and that support the identified knowledge, attitudes, and practices; and barriers to and facilitators for parents' use of practices that lead to healthy child outcomes as well as their participation in effective programs and services. This report makes recommendations directed at an array of stakeholders, for promoting the wide-scale adoption of effective programs and services for parents and on areas that warrant further research to inform policy and practice. It is meant to serve as a roadmap for the future of parenting policy, research, and practice in the United States.
Who was your mother before she was a mother? Essays and photos from Brit Bennett, Jennifer Egan, Danzy Senna, Laura Lippman, Jia Tolentino, and many more. In this remarkable collection, New York Times–bestselling novelist Edan Lepucki gathers more than sixty original essays and favorite photographs to explore this question. The daughters in Mothers Before are writers and poets, artists and teachers, and the images and stories they share reveal the lives of women in ways that are vulnerable and true, sometimes funny, sometimes sad, and always moving. Contributors include: Brit Bennett * Jennine Capó Crucet * Jennifer Egan * Angela Garbes * Annabeth Gish * Alison Roman * Lisa See * Danzy Senna * Dana Spiotta * Lan Samantha Chang * Laura Lippman * Jia Tolentino * Tiffany Nguyen * Charmaine Craig * Maya Ramakrishnan * Eirene Donohue * and many others
A large segment of the population struggles with feelings of being detached from themselves and their loved ones. They feel flawed, and blame themselves. Running on Empty will help them realize that they're suffering not because of something that happened to them in childhood, but because of something that didn't happen. It's the white space in their family picture, the background rather than the foreground. This will be the first self-help book to bring this invisible force to light, educate people about it, and teach them how to overcome it.