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This book presents a detailed overview of the development of new viral vector-based vaccines before discussing two major applications: preventive vaccines for infectious diseases and therapeutic cancer vaccines. Viral vector-based vaccines hold a great potential for development into successful pharmaceutical products and several examples at the advanced pre-clinical or clinical stage are presented. Nevertheless, the most efforts were focused on novel and very innovative technologies for new generation of vector-based vaccines. Furthermore, specific topics such as delivery and adjuvant and protection strategies for cell-mediated-based vaccines are presented. Given its scope, the book is a “must read” for all those involved in vaccine development, both in academia and industrial vaccine development.
In the past decade, tensions in Asia have risen as Beijing has become more assertive in maritime disputes with its neighbors and the United States. Although taking place below the threshold of direct military confrontation, China’s assertiveness frequently involves coercive elements that put at risk existing rules and norms; physical control of disputed waters and territory; and the credibility of U.S. security commitments. Regional leaders have expressed increasing alarm that such “gray zone” coercion threatens to destabilize the region by increasing the risk of conflict and undermining the rules-based order. Yet, the United States and its allies and partners have struggled to develop effective counters to China’s maritime coercion. This study reviews deterrence literature and nine case studies of coercion to develop recommendations for how the United States and its allies and partners could counter gray zone activity.
The explosive, true story of a man of God turned fighter pilot who fought and prayed his way through 300 combat missions and two wars. Author Dean E. Hess is the subject of this inspiring autobiography, Battle Hymn, first published in 1956, which tells of his experiences as a U.S. Air Force colonel, including his involvement in the so-called “Kiddy Car Airlift” during the Korean War on December 20, 1950. With the airfield over capacity, Hess sent Korean orphans to an orphanage in Seoul. When the North Korean forces began to capture the city, Hess reportedly organized 15 C-54 Skymaster aircraft to airlift 950 orphans and 80 orphanage staff from the path of the Chinese advance to safety on Jeju Island. When Hess departed Korea in June 1951, a new orphanage on this island held over 1,000 Korean children. The book later served the basis for the 1957 film of the same name, where he was played by Rock Hudson. “Stirring”—San Francisco Chronicle “In his career as a war correspondent Quentin Reynolds has met his share of heroes, but few of them, he says have impressed him as deeply as Col. Dean E. Hess.”—Readers Digest “Twentieth century American soldiers, sailors, airmen and Marines have enjoyed a warm reputation for caring about the children of the lands they have fought in. Col. Dean E. Hess—Air Force humanitarians—well represents this tradition.”—The Times Magazine