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"It’s not every day that one picks up a textbook that can claim to occupy a unique niche, given the multitude of scientific textbooks that are vying for a medical readership. However, with the recent publication of 'Pain-Free Biochemistry: An Essential Guide for the Health Sciences', which is specifically aimed at students of medicine and nursing, one could be left wondering just why nobody thought of this sooner.” –Irish Medical Times, September 14, 2010 If you are an undergraduate nursing or healthcare student about to embark on a short course in biochemistry and feel daunted by the prospect because you’ve done very little chemistry in the past, found it difficult or studied it so long ago you’ve forgotten it all, then this is the book for you. Equally, if clinical practice has brought you back to biochemistry just when you were hoping you could forget it all, this could be your lifeline! Having taught biochemistry to all sorts of students, from nurses to chemical engineers, for more than 30 years, Professor Paul Engel knows how to take the ‘pain’ out of your studies. For those who are a bit wobbly on molecules, bonds, ions, etc. this text also has just enough supporting chemistry slipped in where appropriate to help things make sense. Accessible, enjoyable to read and packed with a wealth of clinical examples from heart disease to cancer and blood clotting to antibiotics, this handy textbook will reveal how biochemistry is fundamental to clinical practice and everyday life. Drugs, diet, disease, DNA – it all comes down to biochemistry. Key Features: Easy to digest: ‘Bite sized’ topics lead you through essential biochemistry without going into intimidating detail. Doesn’t assume you’ve studied chemistry before: Focuses on key concepts and provides all the basic chemistry you might need. Colour coded: Specially designed so you can see, at a glance, which chapters focus on underpinning chemistry, which on basic biochemistry and which on clinical applications. Clinically relevant:Topical examples throughout the text show how getting to grips with biochemistry will help you succeed in healthcare practice. Reinforces your learning: Includes numerous self-test questions with answers throughout. Companion website includes: A complete set of figures from within the book. Extended MCQs with answers and further explanation where relevant.
Chronic pain is common in western countries and entails considerable consequences for the afflicted individuals as well as for the society. Furthermore, chronic pain is complex including an advanced interplay between biological-, psychological- and social aspects. Treatment of chronic pain attempts to decrease pain intensity and increase physical-, psychological- and social functioning. However, the treatment of chronic pain is still not optimized. Different types of physical activity and exercise (PA&E) are commonly applied as non-pharmacological treatment strategies for chronic pain, but the most efficient type and dose of PA&E are unclear. In addition, adherence to prescribed PA&E is often troublesome, which further complicates the application of PA&E as treatment for chronic pain. The aim of this thesis is to increase the knowledge about PA&E as treatment for chronic pain regarding pain intensity, biochemical substances, adherence and attitudes. The findings of this thesis were that a long-term, home-based PA&E intervention comprising strength exercises as well as stretch exercises decreased pain intensity and increased function in women with chronic neck- and shoulder pain. Using microdialysis technique, differences in pain modulatory biochemical substances were found, before the intervention, in painful trapezius muscle compared to pain-free trapezius muscle. In addition, alterations in pain modulatory substances in painful trapezius muscle after the intervention were found, which possibly could imply peripheral physiological effects of PA&E. Furthermore, psychological factors could be associated to the effects of and adherence to the PA&E intervention. An intention to be physically active were expressed by patients with chronic pain, but a discordance between the intention and PA&E-behaviour were evident, even though the PA&E were experienced as valuable. In conclusion, this thesis strengthens the importance of PA&E as treatment for chronic pain. Especially, this thesis increases the knowledge about; possible peripheral pain inhibitory effects after long-term exercise; how psychological factors might affect the results of PA&E; and also about important behavioural aspects that might affect adherence to prescribed PA&E. This thesis highlights the need of more research on physiological pain inhibitory effects of long-term PA&E in chronic pain. Furthermore, improved methods for ensured adherence to prescribed PA&E are necessary in order to optimize the effect of PA&E as treatment for chronic pain.
Advances in Biological Therapy Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Biological Therapy. The editors have built Advances in Biological Therapy Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Biological Therapy in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Biological Therapy Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Functional Biochemistry in Health and Disease provides a clear and straightforward account of the biochemistry that is necessary to understand the physiological functions of tissues or organs essential to the life of human beings. Focusing on the dynamic aspects of biochemistry and its application to the basic functions of the body, the book bridges the gap between biochemistry and medical practice. Carefully structured within five sections, each biochemical, physiological or medical subject that is covered in the book is presented in one complete chapter. Consequently, each subject can be read and studied in isolation although cross-sectional links between the subjects are included where necessary. Background material, both biochemical and medical, that is necessary for an understanding of the subject, is included at the start of each chapter and clear, relevant diagrams enhance students' understanding. * Focuses on medically relevant aspects of biochemistry written from a physiological rather than a chemical perspective. * Clear presentation that minimises the use of jargon. * Each chapter contains boxes on related topics, relevant diagrams and a brief glossary. * Coverage includes athletic performance, apoptosis and the immune system. * Key historical developments are included to show how modern biochemistry has evolved. By linking biochemistry, medical education and clinical practice this book will prove invaluable to students in medical and health sciences, biomedical science and human biology taking an introductory biochemistry course. In addition it will appeal to biochemistry and biology students interested in clinical applications of biochemistry.
Essential reading for candidates for the MRCPath examination and similar postgraduate examinations in clinical biochemistry. The book gives an overview of the acquisition of data, as well as concentrating on clinical aspects of the subject, giving detailed coverage of all conditions where clinical biochemistry is used in diagnosis and management. In common with other diagnostic specialties clinical biochemistry now uses an increasing number of techniques involving the 'new biology': these are covered in this book. It is also increasingly common for medically qualified clinical biochemists to become involved in the clinical management of patients (eg nutritional support) and material on this will be included. - From the author of the popular Clinical Chemistry medical student textbook. - Although there are many competing texts on clinical chemistry, the vast majority concentrate on the technology; this book concentrates on the clinical. - Ideally suited for preparation for the MRCPath and similar examination. - Expanded sections on haematology and immunology for clinical biochemists provide a thorough understanding of both laboratory and clinical aspects - New chapters are included on important evolving areas such as the metabolic response to stress, forensic aspects of clinical biochemistry and data quality management - An extended editorial team - including three expert new additions – ensures accuracy of information and relevance to current curricula and clinical practice - A superb new accompanying electronic version provides an enhanced learning experience and rapid reference anytime, anywhere! Elsevier ExpertConsult.com Enhanced eBooks for medical professionals Compatible with PC, Mac®, most mobile devices and eReaders, browse, search, and interact with this title – online and offline. Redeem your PIN at expertconsult.com today! - Straightforward navigation and search across all Elsevier titles - Seamless, real-time integration between devices - Adjustable text size and brightness - Notes and highlights sharing with other users through social media - Interactive content
This book discusses and explains the importance of biochemistry knowledge in understanding what happens to patients during anesthesia and/or to those being in intensive care. It covers a wide range of topics, such as Cerebral Edema, Shock, Blood-Brain Barrier, The Pulmonary surfactant, The Acid – Base equilibrium, Local anaesthetics, Perineural adjuvants, Normobaric Oxygen Therapy, Theories of Narcosis. Hyperventilation effects and consequences are also presented. For instance, by hyperventilating a patient with a PaCO2 significantly below 25 mmHg, we risk blocking pyruvic acid carboxylation and transforming it into oxalacetic acid, which in turn knocks out the Krebs cycle, possibly leading to a complication, i.e. to metabolic acidosis and not to compensation for respiratory alkalosis. It is also worth remembering that vitamins are actually molecules of pretty considerable potency and should not be simply intended as integrators. If we inject a patient under intensive care with vitamin C, this not only plays a capillary-protective role but facilitates the conversion of dopamine to noradrenaline. As far as vitamin B6 goes, not only is it the most natural of antiemetics but the coenzyme responsible for transforming glutamate as one of the most powerful excitatory mediators into GABA, one of the fiercest inhibitors. Anesthesiological and intensive care practice require a detailed biochemistry knowledge to avoid onset of complications and/or to deal with unexpected events promptly and appropriately. The book is intended for anesthesiologists, intensivists, anesthesia teachers, anesthesia trainees and residents.
This all-in-one companion to the field of musculoskeletal medicine describes basic concepts and offers practical guidelines for diagnosis and treatment, and contains models of care which assist understanding of basic concepts.