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Featuring instructions for more than 30 chic and ingenious abodes and retreats for dogs, cats, mice, toads, birds, fish, turtles, and bunnies, this book is an invitation to update a primitive perch or an antiquated aquarium. Color images throughout. Concealed Wire-O binding.
The 5th edition of Bioethics provides nursing students with the necessary knowledge and understanding of the ethical issues effecting nursing practice. Groundbreaking in its first edition, Bioethics continues its role as a vital component of nursing education and provides a framework for students to understand the obligations, responsibilities and ethical challenges they will be presented with throughout their careers. This latest edition responds to new and emerging developments in the field and marks a significant turning point in nursing ethics in that it serves not only to inform but also to revitalise and progress debate on the issues presented.
Over a decade has passed since the original edition of The Clinician's Guide to Dermatologic Differential Diagnosis first came out. This massive two volume, second edition undertaking features over 4,000 new photographs of rare and puzzingly symptoms, 98 new chapters, and presents a complete update on all references and new findings since the original publication. This two volume set is designed to assist in the diagnosis of skin disease by presenting a unique and comprehensive approach to differential diagnosis. Organized alphabetically by physical finding each book in the set is meticulously put together for utility and usability. Volume 1 features a comprehensive list of the variety of physical findings a patient might have. It is the text of the work. Volume 2 serves as the atlas with which to cross reference a physical finding. It includes over 10,000 patient photos and strives to feature the rarer, more difficult to encounter pictures to arm the reader with knowledge beyond the basic. Created purely with the reader in mind, The Clinician's Guide to Dermatologic Differential Diagnosis, 2nd Edition strives to enhance the learning and teaching of differential diagnosis within dermatology. These texts are for the patient that defies diagnosis, going through checklists of diseases ensures that no clue is missed in aiding the patient. The sincere hope is that these companion volumes will be helpful in all clinical setting from medical clinic and other specialty clinics to the Dermatology clinic, from medical students to attendings, and from the nurses to the physicians assistants, whether in the academic setting or in the community environment anywhere in the world.
Acoustics is the science concerned with the production, control, transmission, reception, and effects of sound. Its origins began with the study of mechanical vibrations and the radiation of these vibrations through mechanical waves, and still continue today. Research was done to look into the many aspects of the fundamental physical processes involved in waves and sound and into possible applications of these processes in modern life. The study of sound waves also leads to physical principles that can be applied to the study of all waves. The broad scope of acoustics as an area of interest and endeavour can be ascribed to a variety of reasons. First, there is the ubiquitous nature of mechanical radiation, generated by natural causes and by human activity. Then, there is the existence of the sensation of hearing, of the human vocal ability, of communication via sound, along with the variety of psychological influences sound has on those who hear it. Such areas as speech, music, sound recording and reproduction.
NETosis is a unique form of cell death that is characterized by the release of decondensed chromatin and granular contents to the extracellular space. The initial observation of NETosis placed the process within the context of the innate immune response to infections. Neutrophils, the most numerous leukocytes that arrive quickly at the site of an infection, were the first cell type shown to undergo extracellular trap formation. However, subsequent studies showed that other granulocytes are also capable of releasing nuclear chromatin following stimulation. The extracellular chromatin acts to immobilize microbes and prevent their dispersal in the host. Bacterial breakdown products and inflammatory stimuli induce NETosis and the release of NETs requires enzyme activities. Histones in NET chromatin become modified by peptidylarginine deiminase 4 (PAD4) and cleaved at specific sites by proteases. NETs serve for attachment of bactericidal enzymes including myeloperoxidase, leukocyte proteases, and the cathelicidin LL-37. While the benefit of NETs in an infection appears clear, NETs also figure prominently at the center of various pathologic states. Therefore, it is important for NETs to be efficiently cleared; else digestive enzymes may gain access to tissues where inflammation takes place. Persistent NET exposure at sites of inflammation may lead to a further complication: NET antigens may provoke acquired immune responses and, over time, could initiate autoimmune reactions. Recent studies identified aberrant NET synthesis and/or clearance in inflammatory/autoimmune conditions such as systemic lupus erythematosus (SLE), psoriasis, ANCA-positive vasculitis, gout and Felty’s syndrome. In the case of SLE, for example, it appears that LL-37 exposed in the NETs may be a significant trigger of type I Interferon responses in this disease. Recent evidence also implicates aberrant NET formation in the development of endothelial damage, atherosclerosis and thrombosis. NETosis is thus of interest to researchers who investigate innate immune responses, host-pathogen interactions, chronic inflammatory disorders, cell and vascular biology, biochemistry, and autoimmunity. As we approach the 10-year-anniversary of the initial discovery of NETosis, it is useful and timely to review the so far identified mechanisms and pathways of NET formation, their role in bacterial and fungal defense and their putative importance as inducers of autoimmune responses. We look forward to a rich and rigorous discussion of these and related issues that benefit from interdisciplinary approaches, collaborations and exciting discoveries.