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Coho salmon were infected with Aeromonas salmonicida (furunculosis) and treated with oxytetracycline at different stages of disease severity to determine the drug efficacy. The disease was controlled but the degree of control depended on when treatment started. The longer treatment was delayed after infection, the less effective was the treatment. However, it was concluded that feeding 3.5 gm oxytetracycline per 100 pounds of fish per day for 10 days was an effective way of controlling furunculosis in coho salmon.
Oxytetracycline (Terramycin) was reported by Snieszko (158) as an effective therapeutic for the treatment of bacterial diseases of warmwater fish. Subsequent reports gave additional evidence that when used as a feed additive, this drug was effective against bacterial infections normally encountered in warmwater fishes. Routine in vitro drug sensitivity tests of aeromonad, pseudomonad, and myxobacterial species isolated from diseased fish at the Fish Farming Experimental Station since 1964 indicate Terramycin is consistently effective against warmwater fish pathogens.
Coho salmon fed 100 milligrams oxytetracycline per kilogram/day beginning 3 days before exposure to pathogens were protected against infection by Chondrococcus columnaris and drug sensitive Aeromona salmonicida. Over 10,000 times as many A. salmonicida organisms were required to kill pretreated coho salmon as those not treated.
A bibliography comprising annotated citations of 2037 scientific and technical publications from ten series issued by the U.S. Fish and Wildlife Service. Includes a six-page introduction containing a history of the Service and a description of the research and development series.