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This timely and evocative issue of Rheumatic Disease Clinics explores important current and controversial topics in the treatment of osteoporosis. And it answers some tough questions! Here are some examples. How long do I treat my patient? Is there a place for bone turnover markers? How much Vitamin D should I recommend? Controversies around calcium and Vitamin D are explored regarding the coronary risk and pancreatic issues. Emerging therapies are presented, including sclerostin and oral calcitonin. Long-term safety concerns of antiresporptive therapy (ONJ, atypical fracture, would healing) are explained. The utility and limitations of FRAX are covered, as well as Prolia and the RANKL pathway. An update on glucocorticoid induced OP is given. The reader is also brought up to date on men’s health issues and OP. This is an essential issue for any practicing rheumatologist to stay current in the field.
Osteoporosis is one of the most clinically relevant disabling chronic disease encountered in clinical practice. A common cause of osteoporosis is glucocorticoid excess, as glucocorticoids may increase bone resorption, inhibit bone formation, have indirect actions on bone by decreasing intestinal calcium absorption and induce hypercalciuria. This book presents a comprehensive overview of the effects of glucocorticoids on bone metabolism and structure and on the diagnosis and treatment of glucocorticoid-induced osteoporosis. It aims at providing updated information on the pathogenesis, diagnosis and treatment of this often dramatic complication of glucocorticoid excess. Being one of the few publications completely devoted to glucocorticoid-induced osteoporosis it will heighten the awareness of specialists who prescribe glucocorticoids of the clinical relevance of this treatment complication. 'Glucocorticoid-Induced Osteoporosis' is addressed to clinical experts as well as to general practitioners who will both benefit from the comprehensive and integrative view of the management of patients exposed to glucocorticoids.
This issue of Rheumatic Disease Clinics, guest edited by Drs. James Katz and Brian Walitt with the NIH, will cover several key aspects of diagnosing and treating Rheumatic Diseases in Older Adults. The Consulting Editor for the series is Dr. Michael Weisman. The topics discussed in the issue will include: Pharmacotherapy Pearls for the Geriatrician, Pathogenesis and Management of Sarcopenia, A Review of Osteoporosis in the Older Adult, Regional Rheumatic Disorders and Rehabilitation in Older Adults, Rheumatologic Manifestations of Malignancy, Sjögren Syndrome and Other Causes of Sicca in Older Adults, Cardiovascular Disease Risk in Patients with Rheumatic Diseases, Update on Crystal-Induced Arthritides, Immune dysregulation in aging with a focus on B cells and their potential clinical consequence, and Spinal Stenosis, among others.
Guest edited by Drs. Jeffrey Curtis, Kevin Winthrop and Kaleb Michaud, this issue of Rheumatic Disease Clinics will cover several key areas of interest related to Technology and Big Data in Rheumatology. This issue is one of four selected each year by our series Consulting Editor, Dr. Michael Weisman of Cedars-Sinai. Articles in this issue include, but are not limited to: Adherence & Adverse Event Ascertainment through mHealth; Digital Patient Education and Decision Aids; Imaging in the mobile domain; Quality Measures made easier with mHealth data; Patient self-management and tracking; Motivational Counseling and SMS Reminders; Digital Interventions to build community support; Telehealth to solve cases in under-resourced areas; Trials, eConsents, Data Linkage & the Future; Clinical experience with devices; and PROMIS vs legacy data instruments.
This first-ever Surgeon General's Report on bone health and osteoporosis illustrates the large burden that bone disease places on our Nation and its citizens. Like other chronic diseases that disproportionately affect the elderly, the prevalence of bone disease and fractures is projected to increase markedly as the population ages. If these predictions come true, bone disease and fractures will have a tremendous negative impact on the future well-being of Americans. But as this report makes clear, they need not come true: by working together we can change the picture of aging in America. Osteoporosis, fractures, and other chronic diseases no longer should be thought of as an inevitable part of growing old. By focusing on prevention and lifestyle changes, including physical activity and nutrition, as well as early diagnosis and appropriate treatment, Americans can avoid much of the damaging impact of bone disease and other chronic diseases. This Surgeon General's Report brings together for the first time the scientific evidence related to the prevention, assessment, diagnosis, and treatment of bone disease. More importantly, it provides a framework for moving forward. The report will be another effective tool in educating Americans about how they can promote bone health throughout their lives. This first-ever Surgeon General's Report on bone health and osteoporosis provides much needed information on bone health, an often overlooked aspect of physical health. This report follows in the tradition of previous Surgeon Generals' reports by identifying the relevant scientific data, rigorously evaluating and summarizing the evidence, and determining conclusions.
Corticosteroids represent the most important and frequently used class of anti-inflammatory and immunosuppressant agents in the management of many rheumatological conditions. Included in this issue will be articles on the following topics: Glucocorticoid use in intra-articular and soft tissue injections, corticosteroids and osteoporosis, corticosteroids in lupus, ANCA associated vasculitis, and many more!
Thi sissue of Rheumatic Disease Clinics will focus on reproductive health and will include articles on the following: Contraception; infertility - prevention and management; reproductive health screening; biomarkers; use of corticosteroids; and many more exciting articles!
This issue of Rheumatic Disease Clinics, guest edited by Dr. Maripat Corr, will discuss Pain in Rheumatic Diseases. This issue is one of four selected each year by series Consulting Editor, Dr. Michael Weisman. Topics discussed in this issue include, but are not limited to: Pain mechanisms in patients with rheumatic diseases, The back-pain assessment and treatment in clinical practice, Basic mechanisms of pain in osteoarthritis – experimental observations, NGF promise for management of pain in OA – clinical and experimental aspects, Pivotal role of pain in the lupus patient – cause or effect of poor outcomes, Cannabinoids-hope or hype for pain, Sex differences in Models of pain, Neuropathic pain in AS, and Relationship between inflammation and pain – RA as a model.
This issue of Rheumatic Disease Clinics provides important updates in myopathies. The following essential topics are covered. Clinical features, pathophysiology, and treatment of polymyositis and dermatomyositis; inclusion body myositis; metabolic myopathies; drug-induced myopathies; muscular dystrophies and neurologic diseases; laboratory testing and imaging; electrophysiological studies; metabolic and genetic testing; and pathology.
This Open Access book presents practical approaches to managing patients affected by various rheumatological diseases, allowing readers to gain a better understanding of the various clinical expressions and problems experienced by these patients. Discussing rheumatology from an organ systems perspective, it highlights the importance ofdetailed musculoskeletal examinations when treating patients affected by rheumatological diseases. The book first explores the latest diagnostic approaches and offers key tips for accurate musculoskeletal examinations before addressing the various treatment modalities, with a particular focus on the most common joints involved in rheumatoid arthritis: the wrists and the metacarpophalangeal joints (2nd and 3rd). Featuring easy-to-understand flow diagrams and explaining the common medical problems associated with rheumatic disease, such as shortness of breath and anemia, it is not only a valuable resource to rheumatologists, but will also appeal to medical students, junior residents, and primary healthcare physicians.