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Important aims of clinical research include the development of study goals, research design methodology and outcome measures. Proper articulation of these goals will lead to the determination of the outcomes of safety, efficacy and/or effectiveness of new dental drugs, biologics, devices or procedures to improve patient care. This book guides researchers in creating protocols that lead to meaningful outcomes in oral and maxillofacial tissue regeneration. This text is written by a group of eminent investigators with expertise in all facets of clinical research from methodology to clinical protocols. Covered topics include oral/maxillofacial imaging, histomorphometry, examiner calibration, good clinical practice, ridge augmentation, soft/hard tissue grafting, sinus augmentation and periodontal regeneration protocols. This text is an essential reference guide for clinical researchers engaged in research in oral tissue regeneration.
"The goal of clinical investigation in oral and maxillofacial regeneration is to determine the safety and efficacy of new biologics for the benefit of patients, which requires that researchers select appropriate animal models and corresponding experimental designs to enable the next steps toward human investigation. This book guides researchers in creating protocols that lead to meaningful outcomes. Written by a coterie of contributors with experience in preclinical trials, chapters outline how to create workable protocols, gain maximum information from preclinical investigations, and avoid common early career errors. Covered topics include research in soft and hard tissue, osseointegrated implants, periodontal regeneration, ridge preservation, horizontal and vertical ridge expansion, and augmentation of the sinus floor. Biomaterials used for regenerative efforts include osteoconductive products as well as tissue engineering."--Publisher.
This edited book is a compilation of scholarly articles on the latest developments in the field of additive manufacturing, discussing nature-inspired and artificial intelligence–aided additive manufactured processes for different materials including biomanufacturing, and their applications, as well as various methods to enhance the characteristics of the materials produced, the efficiency of the manufacturing process itself, as well as optimal ways to develop a product in minimum time. The book explores the advancements in additive manufacturing from prefabrication stage to final product, with real-time defect detection, control, and process efficiency improvement covered. This book will be a great resource for engineers, researchers, and academics involved in this revolutionary and unique field of manufacturing. - Discusses modeling of additive manufacturing processes by artificial intelligence - Looks at the optimization of designs, technologies, and material fabrication and the use of simulation in additive manufacturing - Includes case studies and real-world industrial problems and solutions
Biocompatibility and Performance of Medical Devices, Second Edition, provides an understanding of the biocompatibility and performance tests for ensuring that biomaterials and medical devices are safe and will perform as expected in the biological environment. Sections cover key concepts and challenges faced in relation to biocompatibility in medical devices, discuss the evaluation and characterization of biocompatibility in medical devices, describe preclinical performance studies for bone, dental and soft tissue implants, and provide information on the regulation of medical devices in the European Union, Japan and China. The book concludes with a review of histopathology principles for biocompatibility and performance studies. - Presents diverse insights from experts in government, industry and academia - Delivers a comprehensive overview of testing and interpreting medical device performance - Expanded to include new information, including sections on managing extractables, accelerating and simplifying medical device development through screening and alternative biocompatibility methods, and quality strategies which fasten device access to market
Discover the latest edition of the cornerstone reference on periodontology and implant dentistry that combines scholarship and science with practical clinical instruction The Seventh Edition of Lindhe's Clinical Periodontology and Implant Dentistry brings together a distinguished team of periodontal specialists and academics who deliver another must-have resource for students, researchers, and practitioners specializing in periodontal care and implant dentistry. Seamlessly integrating the foundational science behind periodontology with practical clinical protocols in two comprehensive volumes, the chapters cover anatomy, microbiology, occlusion trauma, pathology, tissue regeneration, treatment planning protocols, infection control, reconstructive therapy, occlusal and prosthetic therapy, and more. The Seventh Edition of Lindhe's Clinical Periodontology and Implant Dentistry: Provides an introduction to anatomy, including periodontal tissues, the edentulous ridge, the mucosa at teeth and implants, and osseointegration Discusses the epidemiology of periodontal and peri-implant diseases Explores the microbiology, including dental biofilms and calculus, periodontal infections, peri-implant infections, the pathogenesis of gingivitis and periodontitis, and the genetic susceptibility to periodontal disease Includes the latest perio- and peri-implant disease classifications Contains updated evidence-based preventive and treatment modalities for the treatment of periodontal and peri-implant diseases Features the latest evidence-based therapeutic alternatives on the use of dental implants to rehabilitate the lost dentition Perfect for postgraduate dental students, researchers, and practitioners specializing in periodontal care and implant dentistry, Lindhe's Clinical Periodontology and Implant Dentistry continues to be the cornerstone reference work on periodontology.
A compilation of 15 years' work, this book is a contemporary introduction to the art and science of oral and maxillofacial surgery practice for residents. Packed with useful and practical information, the book is written in a succinct style that is easy to understand and follow, even for readers whose first language is not English. Liberally illustrated with simple color diagrams and clinical pictures. Lecture Notes functions as a teaching manual, a basic resource for curriculum development, and a useful guide for the preparation of examinations.
Novel injectable materials for non-invasive surgical procedures are becoming increasingly popular. An advantage of these materials include easy deliverability into the body, however the suitability of their mechanical properties must also be carefully considered. Injectable biomaterials covers the materials, properties and biomedical applications of injectable materials, as well as novel developments in the technology.Part one focuses on materials and properties, with chapters covering the design of injectable biomaterials as well as their rheological properties and the mechanical properties of injectable polymers and composites. Part two covers the clinical applications of injectable biomaterials, including chapters on drug delivery, tissue engineering and orthopaedic applications as well as injectable materials for gene delivery systems. In part three, existing and developing technologies are discussed. Chapters in this part cover such topics as environmentally responsive biomaterials, injectable nanotechnology, injectable biodegradable materials and biocompatibility. There are also chapters focusing on troubleshooting and potential future applications of injectable biomaterials.With its distinguished editor and international team of contributors, Injectable biomaterials is a standard reference for materials scientists and researchers working in the biomaterials industry, as well as those with an academic interest in the subject. It will also be beneficial to clinicians. - Comprehensively examines the materials, properties and biomedical applications of injectable materials, as well as novel developments in the technology - Reviews the design of injectable biomaterials as well as their rheological properties and the mechanical properties of injectable polymers and composites - Explores clinical applications of injectable biomaterials, including drug delivery, tissue engineering, orthopaedic applications and injectable materials for gene delivery systems
This first volume focuses on implant therapy for single-tooth replacement in the esthetic zone. It guides readers through the entire treatment process, beginning with assessment of the patient's individual esthetic risk profile and proceeding through ideal three-dimensional implant placement and proven prosthetic management options. Various procedures are illustrated through patient case studies. Detailed illustrations serve to clarify any potential ambiguities, and potential complications are explored to avert the most common problems. The ITI Treatment Guide series, a compendium of evidence-based implant therapy techniques employed in daily practice, offers a comprehensive overview of various therapeutic options. Written by expert clinicians of worldwide renown and using an illustrated step-by-step approach, the ITI Treatment Guide shows practitioners how to manage different clinical situations, emphasizing sound diagnostics, evidence-based treatment concepts, and predictable treatment outcomes throughout.
In this book, leading experts from around the world present the latest knowledge on the risk factors for peri-implant diseases and also examine the prevalence, etiology, and treatment strategy. Reports have suggested that a variety of risk factors, including poor oral hygiene, a history of periodontitis, diabetes, smoking, lack of keratinized mucosa, and implant surface topography, are associated with these diseases. Periodontally compromised patients who do not adhere completely to the supportive periodontal therapy have been found to present a higher implant failure rate, and several studies have shown that periodontal pathogens can translocate from periodontally involved teeth to the peri-implant sulci in partially dentate patients, highlighting the importance of periodontal treatment of the residual dentition prior to placement of dental implants. Recently a new concept was proposed as intraindividual variation exists in core microbiota in peri-implantitis and periodontitis. In elucidating the strength of association of peri-implant diseases with all of the risk factors identified to date, the book will be of interest to practitioners and other professionals in the field.