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A groundbreaking, haunting, and profoundly moving history of modernity's greatest tragedy: concentration camps. For over 100 years, at least one concentration camp has existed somewhere on Earth. First used as battlefield strategy, camps have evolved with each passing decade, in the scope of their effects and the savage practicality with which governments have employed them. Even in the twenty-first century, as we continue to reckon with the magnitude and horror of the Holocaust, history tells us we have broken our own solemn promise of "never again." In this harrowing work based on archival records and interviews during travel to four continents, Andrea Pitzer reveals for the first time the chronological and geopolitical history of concentration camps. Beginning with 1890s Cuba, she pinpoints concentration camps around the world and across decades. From the Philippines and Southern Africa in the early twentieth century to the Soviet Gulag and detention camps in China and North Korea during the Cold War, camp systems have been used as tools for civilian relocation and political repression. Often justified as a measure to protect a nation, or even the interned groups themselves, camps have instead served as brutal and dehumanizing sites that have claimed the lives of millions. Drawing from exclusive testimony, landmark historical scholarship, and stunning research, Andrea Pitzer unearths the roots of this appalling phenomenon, exploring and exposing the staggering toll of the camps: our greatest atrocities, the extraordinary survivors, and even the intimate, quiet moments that have also been part of camp life during the past century. "Masterly"-The New Yorker A Smithsonian Magazine Best History Book of the Year
One of the most highly-regarded and respected authors and lecturers in the West, Giovanni Maciocia, illuminates and examines the art of traditional Chinese acupuncture with this in-depth look at the secondary channels and other key structures encompassing the human body in Chinese anatomy. This book describes in detail the pathways, pathology, diagnosis, and treatment of the Luo, Muscle, and Divergent secondary channels, as well as other key structures such as the Cou Li and Huang membranes, and gives a thorough, clear overview of subjects poorly understood and incompletely covered in other English language texts. Over one third of the book is dedicated to the Eight Extraordinary Channels, providing the reader with the most in-depth information available in the English language. Drawing on his broad clinical experience, the author covers the energetic physiology, pathology and points by body area, providing ease of access for both the student and practitioner of acupuncture. The Channels of Acupuncture presents comprehensive and clear information on an essential part of traditional Chinese medicine. - Covers key channels not thoroughly discussed in other texts, giving all students and practitioners detailed and clear material to guide them in their practice of acupuncture. - Offers new information and insight on other key body structures in Chinese medicine including extraordinary vessels as well as the Cou Li and Huang membranes. - Clear illustrations depict the exact channel pathways, diminishing any confusion about their location. - Case histories and research from Giovanni Maciocia present a wide range of experiences and examples of clinical practice and study.
Includes cases argued and determined in the District Courts of the United States and, Mar./May 1880-Oct./Nov. 1912, the Circuit Courts of the United States; Sept./Dec. 1891-Sept./Nov. 1924, the Circuit Courts of Appeals of the United States; Aug./Oct. 1911-Jan./Feb. 1914, the Commerce Court of the United States; Sept./Oct. 1919-Sept./Nov. 1924, the Court of Appeals of the District of Columbia.
DNA replication, a central event for cell proliferation, is the basis of biological inheritance. Complete and accurate DNA replication is integral to the maintenance of the genetic integrity of organisms. In all three domains of life, DNA replication begins at replication origins. In bacteria, replication typically initiates from a single replication origin (oriC), which contains several DnaA boxes and the AT-rich DNA unwinding element (DUE). In eukaryotic genomes, replication initiates from significantly more replication origins, activated simultaneously at a specific time. For eukaryotic organisms, replication origins are best characterized in the unicellular eukaryote budding yeast Saccharomyces cerevisiae and the fission yeast Schizosaccharomyces pombe. The budding yeast origins contain an essential sequence element called the ARS (autonomously replicating sequence), while the fission yeast origins consist of AT-rich sequences. Within the archaeal domain, the multiple replication origins have been identified by a predict-and-verify approach in the hyperthermophilic archaeon Sulfolobus. The basic structure of replication origins is conserved among archaea, typically including an AT-rich unwinding region flanked by several short repetitive DNA sequences, known as origin recognition boxes (ORBs). It appears that archaea have a simplified version of the eukaryotic replication apparatus, which has led to considerable interest in the archaeal machinery as a model of that in eukaryotes. The research on replication origins is important not only in providing insights into the structure and function of the replication origins but also in understanding the regulatory mechanisms of the initiation step in DNA replication. Therefore, intensive studies have been carried out in the last two decades. The pioneer work to identify bacterial oriCs in silico is the GC-skew analysis. Later, a method of cumulative GC skew without sliding windows was proposed to give better resolution. Meanwhile, an oligomer-skew method was also proposed to predict oriC regions in bacterial genomes. As a unique representation of a DNA sequence, the Z-curve method has been proved to be an accurate and effective approach to predict bacterial and archaeal replication origins. Budding yeast origins have been predicted by Oriscan using similarity to the characterized ones, while the fission yeast origins have been identified initially from AT content calculation. In comparison with the in silico analysis, the experimental methods are time-consuming and labor-intensive, but convincing and reliable. To identify microbial replication origins in vivo or in vitro, a number of experimental methods have been used including construction of replicative oriC plasmids, microarray-based or high-throughput sequencing-based marker frequency analysis, two-dimensional gel electrophoresis analysis and replication initiation point mapping (RIP mapping). The recent genome-wide approaches to identify and characterize replication origin locations have boosted the number of mapped yeast replication origins. In addition, the availability of increasing complete microbial genomes and emerging approaches has created challenges and opportunities for identification of their replication origins in silico, as well as in vivo and in vitro. The Frontiers in Microbiology Research Topic on DNA replication origins in microbial genomes is devoted to address the issues mentioned above, and aims to provide a comprehensive overview of current research in this field.