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The opioid crisis in the United States has come about because of excessive use of these drugs for both legal and illicit purposes and unprecedented levels of consequent opioid use disorder (OUD). More than 2 million people in the United States are estimated to have OUD, which is caused by prolonged use of prescription opioids, heroin, or other illicit opioids. OUD is a life-threatening condition associated with a 20-fold greater risk of early death due to overdose, infectious diseases, trauma, and suicide. Mortality related to OUD continues to escalate as this public health crisis gathers momentum across the country, with opioid overdoses killing more than 47,000 people in 2017 in the United States. Efforts to date have made no real headway in stemming this crisis, in large part because tools that already existâ€"like evidence-based medicationsâ€"are not being deployed to maximum impact. To support the dissemination of accurate patient-focused information about treatments for addiction, and to help provide scientific solutions to the current opioid crisis, this report studies the evidence base on medication assisted treatment (MAT) for OUD. It examines available evidence on the range of parameters and circumstances in which MAT can be effectively delivered and identifies additional research needed.
Drug overdose, driven largely by overdose related to the use of opioids, is now the leading cause of unintentional injury death in the United States. The ongoing opioid crisis lies at the intersection of two public health challenges: reducing the burden of suffering from pain and containing the rising toll of the harms that can arise from the use of opioid medications. Chronic pain and opioid use disorder both represent complex human conditions affecting millions of Americans and causing untold disability and loss of function. In the context of the growing opioid problem, the U.S. Food and Drug Administration (FDA) launched an Opioids Action Plan in early 2016. As part of this plan, the FDA asked the National Academies of Sciences, Engineering, and Medicine to convene a committee to update the state of the science on pain research, care, and education and to identify actions the FDA and others can take to respond to the opioid epidemic, with a particular focus on informing FDA's development of a formal method for incorporating individual and societal considerations into its risk-benefit framework for opioid approval and monitoring.
Divided Legacy (Vols. I-IV) is a history of Western medical philosophy from the time of Hippocrates to the twentieth century, treating it as a unified system of thought rather than a series of fortuitous discovers. Dr. Coulter interprets the development of medical ideas as the product of a conflict between two opposed systems of thought, Empiricism and Rationalism. This third volume of Divided Legacy continues the account of the conflict between the Empirical and the Rationalist approaches to therapeutics but introduces a socio-economic dimension which had earlier been lacking. In the early nineteenth century, Samuel Hahnemann’s formulation of the Empirical therapeutic doctrine, which he called homeopathy. It flourished especially in the United States. This volume traces the history of the rise and decline of this formulation of Empirical therapeutics in the nineteenth century United States. It analyzes the interaction between the homeopathic doctrines and those of the orthodox school and attempts to illustrate the influence of socio-economic constraints on the movement of medical thought during this period.