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This monograph will provide an in-depth mathematical treatment of modern multiple test procedures controlling the false discovery rate (FDR) and related error measures, particularly addressing applications to fields such as genetics, proteomics, neuroscience and general biology. The book will also include a detailed description how to implement these methods in practice. Moreover new developments focusing on non-standard assumptions are also included, especially multiple tests for discrete data. The book primarily addresses researchers and practitioners but will also be beneficial for graduate students.
Useful Statistical Approaches for Addressing Multiplicity IssuesIncludes practical examples from recent trials Bringing together leading statisticians, scientists, and clinicians from the pharmaceutical industry, academia, and regulatory agencies, Multiple Testing Problems in Pharmaceutical Statistics explores the rapidly growing area of multiple c
Missing data pose challenges to real-life data analysis. Simple ad-hoc fixes, like deletion or mean imputation, only work under highly restrictive conditions, which are often not met in practice. Multiple imputation replaces each missing value by multiple plausible values. The variability between these replacements reflects our ignorance of the true (but missing) value. Each of the completed data set is then analyzed by standard methods, and the results are pooled to obtain unbiased estimates with correct confidence intervals. Multiple imputation is a general approach that also inspires novel solutions to old problems by reformulating the task at hand as a missing-data problem. This is the second edition of a popular book on multiple imputation, focused on explaining the application of methods through detailed worked examples using the MICE package as developed by the author. This new edition incorporates the recent developments in this fast-moving field. This class-tested book avoids mathematical and technical details as much as possible: formulas are accompanied by verbal statements that explain the formula in accessible terms. The book sharpens the reader’s intuition on how to think about missing data, and provides all the tools needed to execute a well-grounded quantitative analysis in the presence of missing data.
The International Conference on Linear Statistical Inference LINSTAT'93 was held in Poznan, Poland, from May 31 to June 4, 1993. The purpose of the confer ence was to enable scientists, from various countries, engaged in the diverse areas of statistical sciences and practice to meet together and exchange views and re sults related to the current research on linear statistical inference in its broadest sense. Thus, the conference programme included sessions on estimation, prediction and testing in linear models, on robustness of some relevant statistical methods, on estimation of variance components appearing in linear models, on certain gen eralizations to nonlinear models, on design and analysis of experiments, including optimality and comparison of linear experiments, and on some other topics related to linear statistical inference. Within the various sessions 22 invited papers and 37 contributed papers were presented, 12 of them as posters. The conference gathered 94 participants from eighteen countries of Europe, North America and Asia. There were 53 participants from abroad and 41 from Poland. The conference was the second of this type, devoted to linear statistical inference. The first was held in Poznan in June, 4-8, 1984. Both belong to the series of confer ences on mathematical statistics and probability theory organized under the auspices of the Committee of Mathematics of the Polish Academy of Sciences, due to the ini tiative and efforts of its Mathematical Statistics Section. In the years 1973-1993 there were held in Poland nineteen such conferences, some of them international.