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Animals and Medicine: The Contribution of Animal Experiments to the Control of Disease offers a detailed, scholarly historical review of the critical role animal experiments have played in advancing medical knowledge. Laboratory animals have been essential to this progress, and the knowledge gained has saved countless lives—both human and animal. Unfortunately, those opposed to using animals in research have often employed doctored evidence to suggest that the practice has impeded medical progress. This volume presents the articles Jack Botting wrote for the Research Defence Society News from 1991 to 1996, papers which provided scientists with the information needed to rebut such claims. Collected, they can now reach a wider readership interested in understanding the part of animal experiments in the history of medicine—from the discovery of key vaccines to the advancement of research on a range of diseases, among them hypertension, kidney failure and cancer.This book is essential reading for anyone curious about the role of animal experimentation in the history of science from the nineteenth century to the present.
In 1900, for every 1,000 babies born in the United States, 100 would die before their first birthday, often due to infectious diseases. Today, vaccines exist for many viral and bacterial diseases. The National Childhood Vaccine Injury Act, passed in 1986, was intended to bolster vaccine research and development through the federal coordination of vaccine initiatives and to provide relief to vaccine manufacturers facing financial burdens. The legislation also intended to address concerns about the safety of vaccines by instituting a compensation program, setting up a passive surveillance system for vaccine adverse events, and by providing information to consumers. A key component of the legislation required the U.S. Department of Health and Human Services to collaborate with the Institute of Medicine to assess concerns about the safety of vaccines and potential adverse events, especially in children. Adverse Effects of Vaccines reviews the epidemiological, clinical, and biological evidence regarding adverse health events associated with specific vaccines covered by the National Vaccine Injury Compensation Program (VICP), including the varicella zoster vaccine, influenza vaccines, the hepatitis B vaccine, and the human papillomavirus vaccine, among others. For each possible adverse event, the report reviews peer-reviewed primary studies, summarizes their findings, and evaluates the epidemiological, clinical, and biological evidence. It finds that while no vaccine is 100 percent safe, very few adverse events are shown to be caused by vaccines. In addition, the evidence shows that vaccines do not cause several conditions. For example, the MMR vaccine is not associated with autism or childhood diabetes. Also, the DTaP vaccine is not associated with diabetes and the influenza vaccine given as a shot does not exacerbate asthma. Adverse Effects of Vaccines will be of special interest to the National Vaccine Program Office, the VICP, the Centers for Disease Control and Prevention, vaccine safety researchers and manufacturers, parents, caregivers, and health professionals in the private and public sectors.
This text serves as a practical but comprehensive guide to diagnosing and treating ear, nose, throat, and sinus infections. The 30 chapters have been contributed by otolaryngologists and infectious disease specialists who are experts in the field. Topics include common infections such as otitis media, otitis externa, pharyngitis, laryngitis, and acute bacterial sinusitis, as well as less common infections such as mumps, scrofula, malignant otitis externa, Lemierre’s syndrome, invasive fungal sinusitis, and deep neck infections. Human papillomavirus-related neoplasms, biofilms, chronic sinusitis, antibiotic-resistant infections, and measures to prevent surgical site infections are also discussed. Written with the practicing clinician in mind, Infections of the Ears, Nose, Throat, and Sinuses will be an invaluable aid to otolaryngologists, infectious disease specialists, internists, pediatricians, and primary care providers./div
This book is the first comprehensive history of the anti-diphtheria campaign and the factors which facilitated or hindered the rollout of the national childhood immunization programme in Ireland. It is easy to forget the context in which Irish society opted to embrace mass childhood immunization. Dwyer shows us how we got where we are. He restores Diphtheria's reputation as one of the most prolific child-killers of nineteenth and early twentieth-century Ireland and explores the factors which allowed the disease to take a heavy toll on child health and life-expectancy. Public health officials in the fledgling Irish Free State set the eradication of diphtheria among their first national goals, and eschewing the reticence of their British counterparts, adopted anti-diphtheria immunization as their weapon of choice. An unofficial alliance between Irish medical officers and the British pharmaceutical company Burroughs Wellcome placed Ireland on the European frontline of the bacteriological revolution, however, Wellcome sponsored vaccine trials in Ireland side-lined the human rights of Ireland's most vulnerable citizens: institutional children in state care. An immunization accident in County Waterford, and the death of a young girl, raised serious questions regarding the safety of the immunization process itself, resulting in a landmark High Court case and the Irish Medical Union's twelve-year long withdrawal of immunization services. As childhood immunization is increasingly considered a lifestyle choice, rather than a lifesaving intervention, this book brings historical context to bear on current debate.
This is the third edition of this publication which contains the latest information on vaccines and vaccination procedures for all the vaccine preventable infectious diseases that may occur in the UK or in travellers going outside of the UK, particularly those immunisations that comprise the routine immunisation programme for all children from birth to adolescence. It is divided into two sections: the first section covers principles, practices and procedures, including issues of consent, contraindications, storage, distribution and disposal of vaccines, surveillance and monitoring, and the Vaccine Damage Payment Scheme; the second section covers the range of different diseases and vaccines.
Sean Ward's poems are dense with closely observed details, whether they occur in nature or the guts of an engine, in the human psyche or the intricacies of cat behavior. From a very male perspective, Ward delights in precise terminologies, in the physicality of labor, in the fantasy life that so often underpins the mundane, as when tearing down a shed becomes the act of a Viking berserker, or the assembly of a lawnmower becomes a Zen meditation. Ward's appreciation of craftsmanship reminds one of Eric Gill, his lanky rhythms of Whitman.-- Bryce Milliganauthor, critic, publisher
New emerging diseases, new diagnostic modalities for resource-poor settings, new vaccine schedules ... all significant, recent developments in the fast-changing field of tropical medicine. Hunter's Tropical Medicine and Emerging Infectious Diseases, 10th Edition, keeps you up to date with everything from infectious diseases and environmental issues through poisoning and toxicology, animal injuries, and nutritional and micronutrient deficiencies that result from traveling to tropical or subtropical regions. This comprehensive resource provides authoritative clinical guidance, useful statistics, and chapters covering organs, skills, and services, as well as traditional pathogen-based content. You'll get a full understanding of how to recognize and treat these unique health issues, no matter how widespread or difficult to control. - Includes important updates on malaria, leishmaniasis, tuberculosis and HIV, as well as coverage of Ebola, Zika virus, Chikungunya, and other emerging pathogens. - Provides new vaccine schedules and information on implementation. - Features five all-new chapters: Neglected Tropical Diseases: Public Health Control Programs and Mass Drug Administration; Health System and Health Care Delivery; Zika; Medical Entomology; and Vector Control – as well as 250 new images throughout. - Presents the common characteristics and methods of transmission for each tropical disease, as well as the applicable diagnosis, treatment, control, and disease prevention techniques. - Contains skills-based chapters such as dentistry, neonatal pediatrics and ICMI, and surgery in the tropics, and service-based chapters such as transfusion in resource-poor settings, microbiology, and imaging. - Discusses maladies such as delusional parasitosis that are often seen in returning travelers, including those making international adoptions, transplant patients, medical tourists, and more. - Enhanced eBook version included with purchase, which allows you to access all of the text, figures, and references from the book on a variety of devices.