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Studies of Metabolism in Crops are used to elucidate the degradation pathway of the active ingredient and require the identification of the metabolism and/or degradation products when a pesticide is applied to a crop directly or indirectly. A ...
This Test Guideline describes how to plan and carry out processing studies, i.e. determine residue levels in primary processed commodities following pesticide application on raw agriculture commodities (RAC) under conditions likely to lead to ...
This book focuses on the principles, methods, and interpretation involved in establishing the safety, risk, and hazard assessment of small molecules. It presents the regulatory requirements for risk and hazard identification as per the guidelines of the Organization for Economic Cooperation and Development (OECD), Paris, and the International Council for Harmonisation (ICH) of Technical Requirements for Pharmaceuticals for Human Use ICH and Schedule ‘Y’, India. It serves as reference material for undergraduate and postgraduate pharmacy degree students as well as senior researchers to learn about the principles, methods, and interpretations of systemic dosage (acute and repeated dose) and genotoxicity (in vitro and in vivo), special toxicological investigations such as reproductive and developmental toxicology, carcinogenicity, and toxicokinetics using animal models or in vitro methods, as applicable. This book is the first of its kind in providing information on the principles and methods of implementation of Good Laboratory Practice based on the guidelines of OECD. It includes detailed chapters about the regulatory requirements and guidelines in pharmaceutical products and agrochemicals. It also describes the infrastructure needed for preclinical studies, including in vivo and in vitro facilities.
The FAO/WHO Manual on development and use of FAO and WHO specifications for pesticides contains general principles and methodologies of the work undertaken by JMPS, is the continuous evaluation of new scientific developments and guidance documents. The Manual gives the historical background of the operation of the JMPS and describes the purpose of the work. The Manual is also used by countries as a guidance document in setting pesticide specifications. This 3rd revision of the Manual contains n ew methodologies/principles developed in recent 5 years and incorporates the current working principles applied by the JMPS.
This Test Guideline describes a method to determine the amount of pesticide residues which may be accumulated into rotational crops via soil uptake following realistic agricultural practices. These data may be used to establish crop rotation ...
This manual incorporates all relevant information and principles that are currently used by the Joint Meeting on Pesticide Residues to estimate maximum residue levels, supervised trials median residue values, and dietary risk from pesticide residues.
Food systems around the world face a triple challenge: providing food security and nutrition for a growing global population; supporting livelihoods for those working along the food supply chain; and contributing to environmental sustainability. Better policies hold tremendous promise for making progress in these domains.
The monographs in this volume summarize the safety data on 11 pesticides that could leave residues in food commodities. These pesticides are aminopyralid, atrazine, azinphos methyl, lamba-cyhalothrin, difenoconazole, dimethomorph, flusilazole, procymidone, profenofos, pyrimethanil and zoxamide. The data summarized in the toxicological monographs served as the basis for the acceptable daily intakes and acute reference doses that were established by the Meeting. This volume and previous volumes of JMPR toxicological evaluations, many of which were published in the FAO Plant Production and Protection Paperseries, contain information that is useful to companies that produce pesticides, government regulatory officers, industrial testing laboratories, toxicological laboratories and universities.
The objective of OECD Test Guidelines for the pesticide residue chemistry is to assess pesticide exposure by identifying these residues in food or animal feedstuffs for purposes of dietary risk assessment and setting Maximum Residue Levels. They ...
The aim of these studies is to demonstrate the time period for which stability has been shown in representative commodities from crops. Freezer storage stability studies should include sufficient starting material and should have a sufficiently high ...