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The OECD Guidelines for the Testing of Chemicals provide a unique tool for assessing the potential effects of chemicals on human health and the environment. Accepted internationally as the standard methods for safety testing, the OECD Guidelines for ...
The OECD Guidelines for the Testing of Chemicals are a collection of internationally agreed methods for testing the safety of chemicals and chemical preparations, including pesticides and industrial chemicals. This 2005 update contains 11 new and 3 revised guidelines.
These Guidance Notes outline core concepts in order to obviate the need to consult large numbers of text books, while still pointing the reader to sources of more detailed or specific information.
Rising concern in recent years over the possible adverse environmental consequences of the use of chemicals has led to a steady increase in national activity towards greater regulation, as well as voluntary agreements with manufacturers for risk management of certain products. This book begins by reviewing the current framework of legislation for the regulation of chemicals in the UK and then reports expert views on both the current situation and possible future developments. Subsequent chapters consider some of the scientific and technical issues, including the evaluation of the risks which chemicals can pose to human life and the environment, and the problems relating to evaluating the risks associated with metals in the environment. Finally, the predictive methods used to model the behaviour of organic chemicals within the environment are described. Highly topical, and with authoritative contributions from international experts, this book covers both the scientific underpinning and the legislative and practical issues of this emotive subject. The detailed coverage of a topic that affects many sectors of industry and society will make it popular with a wide audience of individuals from government organisations, industry or academic research, particularly those in environmental chemistry sectors.
This document contains the report of the OECD Workshop on Sharing Information about New Industrial Chemicals Assessment.
This book provides comprehensive information on the alternative (non-animal) dermal toxicity test methods currently available for industrial, regulatory, and academic use and also explores potential future developments. It encompasses all areas of dermal toxicity, including skin irritation, skin corrosion, skin sensitization, UV-induced effects, and skin genotoxicity. An individual chapter is devoted to each test method, with coverage of the scientific basis, validation status and regulatory acceptance, applications and limitations, available protocols, and potential role within testing strategies. In addition, perspectives from the test developer are presented, for example regarding critical steps in the protocol. The closing section addresses areas that may be of relevance for the future of dermal toxicity safety testing, including the validation and regulatory acceptance of integrated testing strategies, novel complex skin models, and high-throughput screening techniques.
This is a test guideline for testing for Acute Oral Tosxidity using the Acute Toxic Class Method.