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Nucleic Acid Nanotheranostics: Biomedical Applications offers a comprehensive overview of improvements and new trends in fabrication of nanostructures as theranostic multifunctional carriers in gene therapy. With a strong focus on medical applications (comprising diagnosis, therapy and imaging), the book also examines gene therapy in an individual patient's cells or tissues to treat genetic diseases. Sections cover Biomedical and Diagnostic applications of Nucleic Acids, Biologic and Synthetic Advanced Nanostructures for nucleic acid delivery, and important considerations of nanomedicine. This book is a valuable guide for materials scientists, physicians, chemists and engineers, but is also ideal for clinicians wishing to expand their knowledge. - Provides a unique source of knowledge (theoretical as well as practical) on nanotheranostic materials for gene therapy at all levels and related scientific areas - Covers the pros and cons related to viral and nanomaterial-based delivery of nucleic acids in terms of biosafety, carrier selection, synthesis and bioimaging - Presents the only book to include an analysis of nanoformulations approved for clinical use
This book is specifically designed to provide information about various nanocarriers currently developed under the emerging field of nanotheranostics for a sustained, controlled, and targeted co-delivery of diagnostic and therapeutic agents. Diverse theranostic applications of nanotechnology and their limitations are also addressed. It integrates nanobiotechnology with theranostic applications. The combined term nanotheranostics has diverse application particularly in chemotherapy and other infectious diseases.Among other topics addressed are antimicrobial resistance, targeting intra-cellular pathogens, viruses and bacteria, chemotherapy, cancer therapeutics, and inflammatory disorders. This interdisciplinary volume is essential for a diverse group of readers including nanotechnologists, microbiologists, biotechnologists, bioengineering and bioprocess industry.
The application of nanotechnology in the biomedical field, known as nanomedicine, has gained much interest in the recent past as a versatile strategy for selective drug delivery and diagnostic purposes. The nanotheranostic approach, which aims to combine both therapeutic and imaging/diagnostic functionalities, is characterized by a strong pluridisciplinarity where the chemistry of materials, bioconjugate chemistry, pharmaceutical technology, drug delivery, imaging, and pharmacology, work together. Nanotheranostics combine simultaneous non-invasive diagnosis and treatment of diseases with the exciting possibility to monitor drug release and distribution in real time; thus offering the opportunity to optimize treatment outcomes in cancer and other severe diseases. Clinical applications of nanotheranostics would enable earlier detection and treatment of diseases, and earlier assessment of the response, thus allowing to identify patients which would potentially respond to therapy and have higher possibilities of a favorable outcome.Nanotheranostics for Personalized Medicine presents an integrated and transdisciplinary description of nanotheranostics. It provides principles of imaging techniques and concrete examples of advances and challenges in the development of nanotheranostics for personalized medicine.This book is written for students (Bachelors to Doctoral level) as well as experienced researchers, in academia or the industry, interested in this emerging concept in the nanomedicine field.
This Brief introduces SuperParamagnetic Iron Oxide Nanoparticles (SPIONs), the different synthesis approaches, their applications in the field of diagnostics and treatment and finally as theranostic agents in cancer.
This book is the first to focus specifically on cancer nanotheranostics. Each of the chapters that make up this comprehensive volume is authored by a researcher, clinician, or regulatory agency member known for their expertise in this field. Theranostics, the technology to simultaneously diagnose and treat a disease, is a nascent field that is growing rapidly in this era of personalized medicine. As the need for cost-effective disease diagnosis grows, drug delivery systems that can act as multifunctional carriers for imaging contrast and therapy agents could provide unique breakthroughs in oncology. Nanotechnology has enabled the development of smart theranostic platforms that can concurrently diagnose disease, start primary treatment, monitor response and initiate secondary treatments if required. In oncology, chemotherapeutics have been routinely used. Some drugs have proven effective but all carry risks of adverse side effects. There is growing interest in using remotely triggered drug delivery systems to limit cytotoxicity in the diseased area. This book reviews the use of theranostic nanoparticles for cancer applications over the past decade. First, it briefly discusses the challenges and limitations of conventional cancer treatments, and presents an overview of the use of nanotechnology in treating cancer. These introductory chapters are followed by those exploring cancer diagnosis and a myriad of delivery methods for nanotherapeutics. The book also addresses multifunctional platforms, treatment monitoring, and regulatory considerations. As a whole, the book aims to briefly summarize the development and clinical potential of various nanotheranostics for cancer applications, and to delineate the challenges that must be overcome for successful clinical development and implementation of such cancer theranostics.
This book spans diverse aspects of modified nucleic acids, from chemical synthesis and spectroscopy to in vivo applications, and highlights studies on chemical modifications of the backbone and nucleobases. Topics discussed include fluorescent pyrimidine and purine analogs, enzymatic approaches to the preparation of modified nucleic acids, emission and electron paramagnetic resonance (EPR) spectroscopy for studying nucleic acid structure and dynamics, non-covalent binding of low- and high-MW ligands to nucleic acids and the design of unnatural base pairs. This unique book addresses new developments and is designed for graduate level and professional research purposes.
Nanotheranostics is a recent medical field which integrates diagnostic imaging protocols and therapeutic functions to monitor real time drug release in the body and distribution to the target site. The combined processes allow technicians to observe the effectiveness of a specifically designed drug candidate and predict its possible side effects. All these features help clinicians in optimizing treatment options for cancer and other diseases for the individual patient. Current research is tailored to individual therapy because each drug may display a variety of responses depending on variations in an individual’s genetics and subsequently, their clinical biochemistry. Many tumors are still challenging for therapists in terms of available treatment and nanotheranostic strategies may help them to combat cancer more efficiently. Advances in Cancer Nanotheranostics for Experimental and Personalized Medicine presents information about current theranostic technologies in use at clinics and recent research on nanotheranostic applications, with a focus on cancer treatment. Information is presented in seven organized chapters that cover the basics of cancer nanotheranostics, tumor microenvironmental factors, gene therapy and gene delivery concepts, and the combined application of diagnostic imaging with cancer chemotherapy. A chapter focusing on the role of non-coding MRNAs in breast cancer carcinogenesis is also included, giving readers a glimpse of the complexities in the molecular biology of cancer which drive the need for new theranostic technologies. The book is of interest to medical professionals (including oncologists and specialists in internal medicine), diagnostic imaging technicians, and researchers in the fields of pharmacology, molecular biology and nuclear medicine.
Cancer Nanotheranostics, Volume 2 continues the discussion of the important work being done in this field of cancer nanotechnology. The contents of these two volumes are explained in detail as follows. In the first volume of Cancer Nanotheranostics, we discuss the role of different nanomaterials for cancer therapy including lipid-based nanomaterials, protein and peptide-based nanomaterials, polymer-based nanomaterials, metal-organic nanomaterials, porphyrin-based nanomaterials, metal-based nanomaterials, silica-based nanomaterials, exosome-based nanomaterials, and nano-antibodies. This important second volume discusses nano-based diagnosis of cancer, nano-oncology for clinical applications, nano-immunotherapy, nano-based photothermal cancer therapy, nanoerythrosomes for cancer drug delivery, regulatory perspectives of nanomaterials, limitations of cancer nanotheranostics, safety of nanobiomaterials for cancer nanotheranostics, multifunctional nanomaterials for targeting cancer nanotheranostics, and the role of artificial intelligence in cancer nanotheranostics. Volume 2 is a vital continuation of this two-volume set. Together, these two volumes create a comprehensive and unique examination of this important area of research.
New Antisense Strategies: Chemical Synthesis of RNA Oligomers, by Junichi Yano und Gerald E. Smyth Development and Modification of Decoy Oligodeoxynucleotides for Clinical Application, by Mariana Kiomy Osako, Hironori Nakagami und Ryuichi Morishita Modulation of Endosomal Toll-Like Receptor-Mediated Immune Responses by Synthetic Oligonucleotides, by Ekambar R. Kandimalla und Sudhir Agrawal Delivery of Nucleic Acid Drugs, by Yan Lee und Kazunori Kataoka Aptamer: Biology to Applications, by Yoshikazu Nakamura Development and Clinical Applications of Nucleic Acid Therapeutics, by Veenu Aishwarya, Anna Kalota und Alan M. Gewirtz
This book covers topics related to drug delivery, biomaterials, drug design, formulation development, nanoscience, and nanotechnology. It describes the fundamental concepts in nanotechnology and their different applications in biotechnology to solve engineering challenges and generate new areas of technological development. Nanobiotechnology: Applications of Nanomaterials in Biotechnology, Medicine, and Healthcare covers vast application areas that include medical science, material science, pharmaceutical science, and environmental science. Section 1 presents recent research updates on the different nanomaterials, which are promising in different medical and biotechnological applications. Applications of nanomaterials as bone replacement orthopedic implants have revolutionized the treatment of orthopedic surgery. Nanostructured polymeric materials have gained immense research attention as therapeutic carriers for the precise delivery of drugs at targeted sites. Nanocellulose is recognized as a promising green nanomaterial due to its renewability and abundance in nature. Scientific topics on the most recent scientific and technological advances and applications of different nanostructured materials are presented in this section. Section 2 focuses on the novel synthesis methods that are used extensively and are promising for large-scale production of inorganic and nanostructured materials. Section 3 covers the applications of nanotools in the treatment of different diseases, including cancers and genetic diseases. The increasing use of nanotechnology will bring changes in the manufacturing processes of nanomaterials. The applications of nanomaterials in the field of medical imaging and molecular detection are presented in section 4. This book will be useful for students, researchers, scientists, academicians, and industrial manufacturers to understand the importance and applicability of nanomaterials in the field of biotechnology and medical science.