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Novel Platforms for Drug Delivery Applications covers diverse aspects in the design, synthesis and characterization of novel drug delivery platforms and devices. This book comprehensively details the development, application and performance of various novel molecular frameworks as potent drug delivery vehicles. Chapters cover a range of materials and molecular platforms for drug delivery, from hydrogels, nanocarriers and metal-organic-frameworks, to ?-cyclodextrin and polyphosphazene. Each chapter discusses the benefits and limitations of each drug delivery system, as well as toxicological and safety implications. This book offers an interdisciplinary approach to this fast-moving topic, bridging the disciplines of materials science and pharmacology. - Provides an up-to-date single resource on novel drug delivery platforms, a rapidly evolving field of research - Covers a broad range of materials, systems and release mechanisms, including in vivo and in vitro studies - Describes the synthesis, properties, formulation and application of various novel drug delivery systems
Nanotechnology for Oral Drug Delivery: From Concept to Applications discusses the current challenges of oral drug delivery, broadly revising the different physicochemical barriers faced by nanotechnolgy-based oral drug delivery systems, and highlighting the challenges of improving intestinal permeability and drug absorption. Oral delivery is the most widely used form of drug administration due to ease of ingestion, cost effectiveness, and versatility, by allowing for the accommodation of different types of drugs, having the highest patient compliance. In this book, a comprehensive overview of the most promising and up-to-date engineered and surface functionalized drug carrier systems, as well as opportunities for the development of novel and robust delivery platforms for oral drug administration are discussed. The relevance of controlling the physicochemical properties of the developed particle formulations, from size and shape to drug release profile are broadly reviewed. Advances in both in vitro and in vivo scenarios are discussed, focusing on the possibilities to study the biological-material interface. The industrial perspective on the production of nanotechnology-based oral drug delivery systems is also covered. Nanotechnology for Oral Drug Delivery: From Concept to Applications is essential reading for researchers, professors, advanced students and industry professionals working in the development, manufacturing and/or commercialization of nanotechnology-based systems for oral drug delivery, targeted drug delivery, controlled drug release, materials science and biomaterials, in vitro and in vivo testing of potential oral drug delivery technologies. Highlights the relevance of oral drug delivery in the clinical setting Covers the most recent advances in the field of nanotechnology for oral drug delivery Provides the scientific community with data that can facilitate and guide their research
Microfluidics for Pharmaceutical Applications: From Nano/Micro Systems Fabrication to Controlled Drug Delivery is a concept-orientated reference that features case studies on utilizing microfluidics for drug delivery applications. It is a valuable learning reference on microfluidics for drug delivery applications and assists practitioners developing novel drug delivery platforms using microfluidics. It explores advances in microfluidics for drug delivery applications from different perspectives, covering device fabrication, fluid dynamics, cutting-edge microfluidic technology in the global drug delivery industry, lab-on-chip nano/micro fabrication and drug encapsulation, cell encapsulation and delivery, and cell- drug interaction screening. These microfluidic platforms have revolutionized the drug delivery field, but also show great potential for industrial applications.
This research book covers the major aspects relating to the use of novel delivery systems in enhancing both transdermal and intradermal drug delivery. It provides a review of transdermal and intradermal drug delivery, including the history of the field and the various methods employed to produce delivery systems from different materials such as device design, construction and evaluation, so as to provide a sound background to the use of novel systems in enhanced delivery applications. Furthermore, it presents in-depth analyses of recent developments in this exponentially growing field, with a focus on microneedle arrays, needle-free injections, nanoparticulate systems and peptide-carrier-type systems. It also covers conventional physical enhancement strategies, such as tape-stripping, sonophoresis, iontophoresis, electroporation and thermal/suction/laser ablation Discussions about the penetration of the stratum corneum by the various novel strategies highlight the importance of the application method. Comprehensive and critical reviews of transdermal and intradermal delivery research using such systems focus on the outcomes of in vivoanimal and human studies. The book includes laboratory, clinical and commercial case studies featuring safety and patient acceptability studies carried out to date, and depicts a growing area for use of these novel systems is in intradermal vaccine delivery. The final chapters review recent patents in this field and describe the work ongoing in industry.
Providing optimal care to patients is a primary concern in the healthcare field. By utilizing the latest resources and research in biomedical applications, the needs and expectations of patients can be successfully exceeded. Novel Approaches for Drug Delivery is an authoritative reference source for the latest scholarly research on emerging developments within the pharmaceutical industry, examining the current state and future directions of drug delivery systems. Highlighting therapeutic applications, predictive toxicology, and risk assessment perspectives, this book is ideally designed for medical practitioners, pharmacists, graduate-level students, scientists, and researchers.
Organic Materials as Smart Nanocarriers for Drug Delivery presents the latest developments in the area of organic frameworks used in pharmaceutical nanotechnology. An up-to-date overview of organic smart nanocarriers is explored, along with the different types of nanocarriers, including polymeric micelles, cyclodextrins, hydrogels, lipid nanoparticles and nanoemlusions. Written by a diverse range of international academics, this book is a valuable reference for researchers in biomaterials, the pharmaceutical industry, and those who want to learn more about the current applications of organic smart nanocarriers. - Explores the most recent molecular- and structure-based applications of organic smart nanocarriers in drug delivery - Highlights different smart nanocarriers and assesses their intricate organic structural properties for improving drug delivery - Assesses how molecular organic frameworks lead to more effective drug delivery systems
Nanobiomaterials in Drug Delivery: Applications of Nanobiomaterials presents novel approaches regarding nanostructured drug delivery systems, revealing the most investigated materials for the development of particular nanobioshuttles. This book brings the results of current research to reach those who wish to use this knowledge in an applied setting, providing one coherent text, with focused chapters and easily accessible information. At its core, it is a collection of titles, bringing together many of the novel applications these materials have in biology, also discussing the advantages and disadvantages of each application and the perspectives of the technologies based on these findings. At the moment, there is no other comparable book series covering all the subjects approached in this set of titles. - Provides up-to-date and well-structured reference material for students, researchers, and practitioners working in the biomedical, biotechnological, and engineering fields - Presents a valuable guide to recent scientific progress, along with most known applications of nanomaterials in the biomedical area - Proposes novel opportunities and ideas for developing or improving technologies in nanomedicine/nanobiology
Drug Delivery Aspects reviews additional features of drug delivery systems, along with the standard formulation development, like preclinical testing, conversion into solid dosage forms, roles of excipients and polymers used on stability and sterile processing. There is a focus on formulation engineering and related large scale (GMP) manufacturing, regulatory, and functional aspects of drug delivery systems. A detailed discussion on biologics and vaccines gives insights to readers on new developments in this direction. The series Expectations and Realities of Multifunctional Drug Delivery Systems examines the fabrication, optimization, biological aspects, regulatory and clinical success of wide range of drug delivery carriers. This series reviews multifunctionality and applications of drug delivery systems, industrial trends, regulatory challenges and in vivo success stories. Throughout the volumes discussions on diverse aspects of drug delivery carriers, such as clinical, engineering, and regulatory, facilitate insight sharing across expertise area and form a link for collaborations between industry-academic scientists and clinical researchers. Expectations and Realities of Multifunctional Drug Delivery Systems connects formulation scientists, regulatory experts, engineers, clinical experts and regulatory stake holders. The wide scope of the book ensures it as a valuable reference resource for researchers in both academia and the pharmaceutical industry who want to learn more about drug delivery systems.
Core-Shell Nanostructures for Drug Delivery and Theranostics: Challenges, Strategies and Prospects for Novel Carrier Systems contains valuable chapters that deal with the fundamentals of nanotechnology for drug delivery, recent developments and research in core-shell nanoparticles for drug-delivery and theranostic applications, and the potential and applications of core-shell nanofiber. This book is a highly valuable resource for scientists interested in the design and development of innovative drug delivery systems, researchers and graduate/postdoctoral students engaged in biomaterials for drug delivery, and R&D managers in the biomaterials and pharmaceutical industry. - Focuses on core-shell nanoparticles and nanofiber for innovative applications, including cancer therapy, controlled release and multi-drug release - Considers future prospects and potential new applications of core-shell nanostructures for drug delivery and theranostics - Explains the principles and essential concepts of nanotechnology for drug delivery systems
The increased understanding of molecular aspects associated with chronic diseases, such as cancer and the role of tumor microenvironment, has led to the identification of endogenous and exogenous stimuli that can be exploited to devise “stimuli-responsive” materials for site-specific drug delivery applications. This book provides a comprehensive account on the design, materials chemistry, and application aspects behind these novel stimuli-responsive materials. Setting the scene, the editors open with a chapter addressing the need for smart materials in delivery applications for therapy, imaging and disease diagnosis. The following chapter describes the key physical and chemical aspects of smart materials, from lipids to polymers to hybrid materials, providing the reader with a springboard to delve into the more application oriented chapters that follow. With in-depth coverage of key drug delivery systems such as pH-responsive, temperature responsive, enzyme-responsive and light responsive systems, this book provides a rigorous foundation to the field. A perfect resource for graduate students and newcomers, the closing chapter on regulatory and commercialization challenges also makes the book ideal for those wanting to take the next step towards clinical translation.