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Research into the use of calcium phosphates in the development and clinical application of biomedical materials has been a significantly diverse activity conducted by a wide range of scientists, engineers, and medical practitioners, among others. The field of research in this area can, hence, be truly defined as interdisciplinary, and much interesting work leading to imaginative and innovative solutions for the improvement of health outcomes continues to be generated. It has been the intention of this Special Issue to summarise a number of current topical research advances in this area, as well as to review the important area of calcium phosphate-based biomaterials, namely, composites of hydroxyapatite with carbon-based materials. The scientific papers contained in this Special Issue report on advances in the areas of dental-based materials science, bone cements, use of biomaterials created from natural sources, influences of added agents such as adipose stem cells and statins on bioactivity as well as surface influences on electrical potential of biomaterials and uses of glow discharge methods to remove impurities from biomaterial surfaces.
Advances in Calcium Phosphate Biomaterials presents a comprehensive, state-of-the-art review of the latest advances in developing calcium phosphate biomaterials and their applications in medicine. It covers the fundamental structures, synthesis methods, characterization methods, and the physical and chemical properties of calcium phosphate biomaterials, as well as the synthesis and properties of calcium phosphate-based biomaterials in regenerative medicine and their clinical applications. The book brings together these new concepts, mechanisms and methods in contributions by both young and “veteran” academics, clinicians, and researchers to forward the knowledge and expertise on calcium phosphate and related materials. Accordingly, the book not only covers the fundamentals but also open new avenues for meeting future challenges in research and clinical applications. Besim Ben-Nissan is a Professor of Chemistry and Forensic Science at the University of Technology, Sydney, Australia
Octacalcium Phosphate Biomaterials: Past, Present and Future is a comprehensive study of octacalcium phosphate (OCP), a next generation biomaterial for bone regeneration. By focusing both on fundamental research and the use of OCP as a scaffold material, this book explores its potential to deliver improved clinical results. Early chapters in the book discuss OCP's effects on bone cell activity, cellular interactions and their role in bone formation, repair and replacement. Later chapters cover topics such as drug delivery, synthesis methodologies and future analysis techniques. This will be an invaluable and unique resource for researchers, clinicians, students and industrialists in the area of orthopedics and dentistry. OCP is known to be a pre-cursor to hydroxyapatite in the human biomineralization process that forms bone and tooth enamel. Research studies that have emerged in recent years suggest OCP's tremendous potential as a bioactive material. - Contains comprehensive, up-to-date information on the basic science, including physical, chemical and biological properties - Presents the clinical potential of octacalcium phosphate biomaterials - Provides a reference point for new research and increased activity in the area of next generation smarter biomaterials for hard tissue repair and regeneration
Nanotechnologies in Preventative and Regenerative Medicine demonstrates how control at the nanoscale can help achieve earlier diagnoses and create more effective treatments. Chapters take a logical approach, arranging materials by their area of application. Biomaterials are, by convention, divided according to the area of their application, with each chapter outlining current challenges before discussing how nanotechnology and nanomaterials can help solve these challenges This applications-orientated book is a valuable resource for researchers in biomedical science who want to gain a greater understanding on how nanotechnology can help create more effective vaccines and treatments, and to nanomaterials researchers seeking to gain a greater understanding of how these materials are applied in medicine. - Demonstrates how nanotechnology can help achieve more successful diagnoses at an earlier stage - Explains how nanomaterials can be manipulated to create more effective drug treatments - Offers suggestions on how the use of nanotechnology might have future applications to create even more effective treatments
Biomaterials in Translational Medicine delivers timely and detailed information on the latest advances in biomaterials and their role and impact in translational medicine. Key topics addressed include the properties and functions of these materials and how they might be applied for clinical diagnosis and treatment. Particular emphasis is placed on basic fundamentals, biomaterial formulations, design principles, fabrication techniques and transitioning bench-to-bed clinical applications. The book is an essential reference resource for researchers, clinicians, materials scientists, engineers and anyone involved in the future development of innovative biomaterials that drive advancement in translational medicine. - Systematically introduces the fundamental principles, rationales and methodologies of creating or improving biomaterials in the context of translational medicine - Includes the translational or commercialization status of these new biomaterials - Provides the reader with enough background knowledge for a fundamental grip of the difficulties and technicalities of using biomaterial translational medicine - Directs the reader on how to find other up-to-date sources (i.e. peer reviewed journals) in the field of translational medicine and biomaterials
Due to a great chemical similarity with the biological calcified tissues, many calcium orthophosphates possess remarkable biocompatibility and bioactivity. Materials scientists use this property extensively to construct artificial bone grafts that are either entirely made of or only surface-coated with the biologically relevant calcium orthophospha
The development of materials for any replacement or regeneration application should be based on the thorough understanding of the structure to be substituted. This is true in many fields, but particularly exigent in substitution and regeneration medicine. The demands upon the material properties largely depend on the site of application and the function it has to restore. Ideally, a replacement material should mimic the living tissue from a mechanical, chemical, biological and functional point of view. Of course this is much easier to write down than to implement in clinical practice. Mineralized tissues such as bones, tooth and shells have attracted, in the last few years, considerable interest as natural anisotropic composite structures with adequate mechanical properties. In fact, Nature is and will continue to be the best materials scientist ever. Who better than nature can design complex structures and control the intricate phenomena (processing routes) that lead to the final shape and structure (from the macro to the nano level) of living creatures? Who can combine biological and physico-chemical mechanisms in such a way that can build ideal structure-properties relationships? Who, else than Nature, can really design smart structural components that respond in-situ to exterior stimulus, being able of adapting constantly their microstructure and correspondent properties? In the described philosophy line, mineralized tissues and biomineralization processes are ideal examples to learn-from for the materials scientist of the future.
Calcium Compounds—Advances in Research and Application: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Calcium Compounds. The editors have built Calcium Compounds—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Calcium Compounds in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Calcium Compounds—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
This book presents a state-of-the-art review of the latest advances in developing calcium- phosphate bone cements and their applications. It covers the synthesis methods, characterization approaches, material modification and novel binders, as well as the fabrication technologies of calcium-phosphate-based biomaterials in regenerative medicine and their clinical applications. It also highlights methodologies for fabricating scaffolds, biofunctional surfaces/interfaces and subsequently modulating the host response to implantable/injectable materials, and integrates a series of discussions and insights into calcium-phosphate cements and constructs in bone regenerative medicine. As such, the book not only covers the fundamentals but also opens new avenues for meeting future challenges in research and clinical applications.
Bone Repair Biomaterials: Regeneration and Clinical Applications, Second Edition, provides comprehensive reviews on materials science, engineering principles and recent advances. Sections review the fundamentals of bone repair and regeneration, discuss the science and properties of biomaterials used for bone repair, including metals, ceramics, polymers and composites, and discuss clinical applications and considerations, with chapters on such topics as orthopedic surgery, tissue engineering, implant retrieval, and ethics of bone repair biomaterials. This second edition includes more chapters on relevant biomaterials and a greatly expanded section on clinical applications, including bone repair applications in dental surgery, spinal surgery, and maxilo-facial and skull surgery. In addition, the book features coverage of long-term performance and failure of orthopedic devices. It will be an invaluable resource for researchers, scientists and clinicians concerned with the repair and restoration of bone. - Provides a comprehensive review of the materials science, engineering principles and recent advances in this important area - Presents new chapters on Surface coating of titanium, using bone repair materials in dental, spinal and maxilo-facial and skull surgery, and advanced manufacturing/3D printing - Reviews the fundamentals of bone repair and regeneration, addressing social, economic and clinical challenges - Examines the properties of biomaterials used for bone repair, with specific chapters assessing metals, ceramics, polymers and composites