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"This thesis addresses nonparametric maximal likelihood (NPML) estimation of the cumulative distribution function (CDF) given multivariate interval censored data (MILD). The methodology consists in applying graph theory to the intersection graph of censored data. The maximal cliques of this graph and their real representations contain all the information needed to find NPML estimates (NPMLE). In this thesis, a new algorithm to determine the maximal cliques of an MICD set is introduced. The concepts of diameter and semi-diameter of the polytope formed by all NPMLEs are introduced and simulation to investigate the properties of the non-uniqueness polytope of the CDF NPMLEs for bivariate censored data is described. Also, an a priori bounding technique for the total mass attributed to a set of maximal cliques by a self-consistent estimate of the CDF (including the NPMLE) is presented." --
This book primarily aims to discuss emerging topics in statistical methods and to booster research, education, and training to advance statistical modeling on interval-censored survival data. Commonly collected from public health and biomedical research, among other sources, interval-censored survival data can easily be mistaken for typical right-censored survival data, which can result in erroneous statistical inference due to the complexity of this type of data. The book invites a group of internationally leading researchers to systematically discuss and explore the historical development of the associated methods and their computational implementations, as well as emerging topics related to interval-censored data. It covers a variety of topics, including univariate interval-censored data, multivariate interval-censored data, clustered interval-censored data, competing risk interval-censored data, data with interval-censored covariates, interval-censored data from electric medical records, and misclassified interval-censored data. Researchers, students, and practitioners can directly make use of the state-of-the-art methods covered in the book to tackle their problems in research, education, training and consultation.
Praise for the First Edition "An indispensable addition to any serious collection on lifetime data analysis and . . . a valuable contribution to the statistical literature. Highly recommended . . ." -Choice "This is an important book, which will appeal to statisticians working on survival analysis problems." -Biometrics "A thorough, unified treatment of statistical models and methods used in the analysis of lifetime data . . . this is a highly competent and agreeable statistical textbook." -Statistics in Medicine The statistical analysis of lifetime or response time data is a key tool in engineering, medicine, and many other scientific and technological areas. This book provides a unified treatment of the models and statistical methods used to analyze lifetime data. Equally useful as a reference for individuals interested in the analysis of lifetime data and as a text for advanced students, Statistical Models and Methods for Lifetime Data, Second Edition provides broad coverage of the area without concentrating on any single field of application. Extensive illustrations and examples drawn from engineering and the biomedical sciences provide readers with a clear understanding of key concepts. New and expanded coverage in this edition includes: * Observation schemes for lifetime data * Multiple failure modes * Counting process-martingale tools * Both special lifetime data and general optimization software * Mixture models * Treatment of interval-censored and truncated data * Multivariate lifetimes and event history models * Resampling and simulation methodology
Based on arbitrarily right-censored observations from a probability density function f deg the existence and uniqueness of the maximum penalized likelihood estimator (MPLE) of f deg is proven. In particular, the first MPLE of Good and Gaskins of a density defined on (0, infinity) is shown to exist and to be unique under arbitrary right-censorship. Furthermore, the MPLE is in the form of a solution to a linear integral equation. (Author).